主要研究方向：

  1）肿瘤精准医学相关诊治分子

  2）纳米物质的生物学效应

中国科学技术大学教授，博士生导师。

获武汉大学医学学士学位及新加坡国立大学理学博士学位，在美国约翰霍普金斯大学从事博士后研究。2007年起担任中国科学技术大学生命医学部教授，合肥微尺度物质科学国家研究中心PI及安徽省立医院双聘教授。长期从事肿瘤分子病理学及医学转化研究，在Nature Nanotechnol., Nature Commun（2篇），Cell Res， Cancer Res（4篇）等杂志上发表SCI论文110余篇(通讯作者论文50余篇)。论文引用总数6500余次，h-index=49。获得中科院优秀导师奖、美国内分泌协会及美国苏珊-库门癌症基金会奖励、法国创新人才计划的支持。担任Am J. Cancer Res.等多家国际期刊资深编委或编委，担任多项国内及海外国家级科研/人才基金或者国家科技进步奖、科技部重点研发计划、基金委自然科学重点项目的会审专家。

代表性论文：

     1. Wu M, Zhang X, Chiou YS, Qian W, Liu X, Zhang M, Yan H, Li S, Li T, Han X, Qian P, Liu S, Pan Y,Wu Z, Lobie PE*, Zhu T*. （2022）Cancer Stem Cell Regulated Phenotypic Plasticity Protects Metastasizing Tumor Cells from Ferroptosis. Nat Commun. 13(1):1371

     2. Yuan H, Yan L, Wu M, Shang Y, Guo Q, Zhang X, Zhu Y, Wu Z, Lobie PE*, Zhu T*. （2022）Analysis of the oestrogen receptor-associated lncRNA landscape identifies a role for ERLC1 in breast cancer progression. Cancer Res. 82(3):391-405

     3. Lu X, Zhu Y, Bai R, Wu Z, Qian W, Yang L, Pandey V, Liu Y, Lobie PE, Chen C*, Zhu T*. (2019) Long-term pulmonary pre-exposure to multi-walled carbon nanotubes promotes breast cancer metastatic cascades. Nature Nanotechnol. 14(7):719-727

4. Zhang W, Wu M, Kang Y, Chong QY, Zhang M, Qian W, Zhang X, Hu L, Zhong Y, Qian P, Kong X, Li G, Ding K, Lobie PE*, Zhu T*. （2018）Loss of Estrogen Regulated MIR135A1 at 3p21.1 Promotes Tamoxifen Resistance in Breast Cancer Cells. Cancer Res. 78(17):4915-4928

5. Li G, Wu X, Qian W, Wu ZS, Cai H, Sun X, Zhang W, Tan S, Qian P, Ding K, Lu X, Zhang X, Yan H, Song H, Huang S, Wu Q, Lobie PE, Shan G, Zhu T*. (2016) CCAR1 5'UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance. Cell Res 26:655-73.

6. Liu Y, Chen C, Qian P,  Lu X, Sun B, Zhang X, Wang L, Gao X, Li H, Chen Z, Tang J, Zhang W, Dong J, Bai R, Lobie PE, Wu Q,  Liu S, Zhang H, Zhao F, Wicha MS, Zhu T*, Zhao Y*. (2015) Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell specific inhibitor.  Nat Commun. 6,5988

7. Lu X, Liu Y, Kong X, Lobie PE, Chen C*, Zhu T*. (2013) Nanotoxicity: A growing need for study in the endocrine system. Small 9,1654-71

8. Qian PX, Banerjee A, Wu ZS, Zhang X, Wang H, Pandey V, Zhang WJ, Lu XF, Tan S, Lobie PE*, Zhu T*. (2012) Loss of SNAIL regulated miR-128-2 on chromosome 3p22.3 promotes mammary epithelial cell oncogenic transformation via targeting multiple stem cell factors. Cancer Res. 72,6036-6050.

9. Jin K, Kong X, Shah T, Penet MF, Wildes F, Sgroi DC, Ma XJ, Huang Y, Kallioniemi A, Landberg G, Bieche I, Lobie PE, Davidson NE, Zaver M. Bhujwalla ZM, Zhu T*, Sukumar S*. (2012) HOXB7 renders breast cancer resistant to tamoxifen through activation of the EGFR Pathway. Proc Natl Acad Sci U S A. 109，2736-41.

10. Qian P, Zuo Z, Wu Z, Meng X, Li G, Wu Z, Zhang W, Tan S, Pandey V, Yao Y, Wang P, Zhao L, Wang J, Wu Q, Song E, Lobie PE, Yin Z*, Zhu T*. (2011) Pivotal Role of Reduced let-7g Expression in Breast Cancer Invasion and Metastasis. Cancer Res. 71,6463-6474.

联系方式：

Tel: 86-551-63601505
Fax:86-551-63601505
e-mail: zhut@ustc.edu.cn