教授 博士生导师 1999年毕业于上海交通大学生命科学学院获理学学士学位 2005毕业于中国科学院上海生物化学与细胞生物学研究所 获细胞生物学博士学位 并获得中科院院长优秀奖 2005年至2012年先后在美国纽约州Wadsworth Center和美国国家癌症研究所(NCI)从事博士后研究工作。
2013年加入中国科学技术大学生命学院，任教授、博士生导师。十多年一直从事肿瘤细胞生物学研究，致力于揭示细胞分裂周期调控在肿瘤发病和治疗中的机制，探索联合靶向治疗和免疫治疗的新策略，为肿瘤的有效诊治提供新思路。主要成果发表在Nature Communications， Cancer Research，Nature Cell Biology（封面文章）， Journal of Cell Biology， Current Biology等权威刊物。
研究兴趣：
1. 肿瘤化疗耐药机理，联合靶向治疗和免疫治疗新策略；
2. 细胞分裂调控与恶性肿瘤发生、发展的关系;
3. 细胞增殖通路与肿瘤免疫和代谢微环境的协同调控机理;。
主要代表性论文
1. Cheng A#, Zhang P#, Wang B#，Yang D#, Duan X, Jiang Y, Xu T, Jiang Y, Shi J, Ding C, Wu G, Sang Z, Wu Q, Wang H, Wu M , Zhang Z, Pan X, Pan Y, Gao P, Zhang H, Zhou C, Guo J* and Yang Z*. 2019. Aurora-A Mediated Phosphorylation of Lactate Dehydrogenase B promotes glycolysis and tumor growth by relieving the substrate inhibition effect. Nature Communications.2019, 10(1):5566.
2. Yin T#, Zhao ZB#, Guo J#, Wang T, Yang JB, Wang C, Long J, Ma S, Huang Q, Zhang K, Ma X, Liu C, Liu S, Lian ZX*, Yang Z*. 2019. Aurora-A inhibition eliminates myeloid cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in breast cancer. Cancer Research. 2019 Mar 22. Highlighted article.
3. Yu F, Jiang Y, Lu L, Cao M, Qiao Y, Liu X, Liu D, Van Dyke T, Wang F, Yao X, Guo J* and Yang Z*2017. Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B Feedback Loop in late G2 phase. Cell Discovery 3, 16049
4. Ma X, Wang L, Huang, Li Y, Yang D, Li T, Li F, Sun L, Wei H, He K, Yu F, Zhao D, Hu L, Xing S, Liu Z, Li K, Guo J, Yang Z, Pan X, Li A, Shi Y, Wang J, Gao P, Zhang H. 2017. Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway. Nature Communications. 8(1):1506.
5. Zhang L, Hou Y, Li Z, Ji X, Wang Z, Wang H, Tian X, Yu F, Yang Z, Pi L, Mitchison TJ, Lu Q, Zhang X. 2017. 27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells. 2017. Elife. 6. pii: e22911
6. Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y and Zhu X. 2012. Misfolded Gbeta2 is recruited to cytoplasmic dynein by Nudel for efficient clearance. Cell Reseach22:1140-1154.
7. Yang Z., Kenny A., Brito D. and Rieder C. 2009. Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments. J Cell Biol.186: 675-684.
8. Yang Z., Loncarek J., Khodjakov A. and Rieder C. 2008. Extra centrosomes and/or chromosomes prolong mitosis in human cells. Nat .Cell Biol. 10: 748-751.
9. Brito D.*, Yang Z.* and Rieder C. 2008. Microtubules do not promote mitotic slippage when the Spindle Assembly Checkpoint cannot be satisfied. J Cell Biol.182(4):623-9. (* Co-first author)
10. Yang Z., Tulu S., Wadsworth P. and Rieder C. 2007. Kinetochore Dynein is Required for Normal Chromosome Motion and Congression Independent of the Spindle Checkpoint. Curr. Biol.17(11): 973-80.
11. Guo J., Yang Z., Song W., Chen Q., Wang F., Zhang Q. and Zhu X. Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly. Mol Biol Cell. 17(2):680-689. 2006.
12. Yang Z., Guo J., Chen Q., Du J., Ding C., and Zhu X.2005. Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death. Mol. Cell. Biol. 25: 4062-4074.
13. Yang, Z., Guo J., Li N., Qian M., Wang S, and. Zhu X. 2003. Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport. Cell Res. 13:275-83.
招生招聘：实验室招收致力于肿瘤细胞生物学研究的博士后、硕博研究生和本科实习生。