杨振业：教授，博士生导师
杨振业，教授，1999年于上海交通大学生命科学院获理学学士学位。2005于中国科学院上海生物化学与细胞生物学研究所获细胞生物学博士学位。2005年至2012年先后在美国纽约州立大学Wadsworth研究中心和美国国家癌症研究所从事博士后研究工作。2012入选 “国家创新人才青年项目”，2013年起任中国科学技术大学生命科学与医学部教授，2019年起兼任中国科学技术大学附属第一医院特任教授。成果以第一和通讯作者发表在Nature Metabolism，Nature Cell Biology，Journal of Cell Biology，Cell Research，Cancer Research, Nature Communications等刊物。现任中国细胞生物学会肿瘤细胞生物学、医学细胞生物学、细胞结构与功能分会;中国抗癌协会肿瘤代谢专业委员会委员，担任多个国际专业杂志的审稿人。
研究兴趣：
1. 非整倍肿瘤细胞分裂及其免疫和代谢调控;
2. 肿瘤化疗耐药机理，联合靶向治疗和免疫治疗新策略；
3. 细胞分裂调控与恶性肿瘤发生、发展的关系;
主要代表性论文
1. Yu F, Zhou Q, Yu W, Zhou T, Cao C, Xie Y, Zhang P, Liu H, He W, Cheng A, Ma X, Wu Q, Zhao Q, Guo J*, Zhang K*, Zhou Y*, Shi J*, Yang Z*. Tumor-associated macrophages promote chemoresistance to Paclitaxel via activating NOTCH2-JAG1 juxtacrine signaling. Mol Cancer. 2026 Jan 10.
2. Liu M, Cheng A, You W, Wu J, Dai C, Wang T, Wu Y, Zhong F, Shi J, Du Y, Hou Z, Gao P, Ruan K, Yang Y, Zhao Y*, Zhang K*, Yang Z*, Guo J*. CDK1-mediated phosphorylation of LDHA fuels mitosis through LDHB-dependent lactate oxidation. EMBO Rep. 2025 (26)20.
3. Zhang Y#, Wu Y#, Cheng A, Cui F, Yang Z*, Guo J*. The lactylation of glucose-6-phosphate dehydrogenase promotes malignant phenotypes in cancer cell lines. Mol Biol Rep. 2025. 52(1):861.
4. Pan Z, Yu F, You W, Li F, Cui F, Guo J*, Yang Z*. Peroxisomal lipid metabolism inhibits Pimozide-induced cancer cell death by regulating ATP homeostasis. Oncogenesis. 2025.14(1):31.
5. Hou C#, Yu F#, Cao C#, Wang T, Pan Z, Zhong M, Liu X, Yao X, Zhang K, Yang Z*, Guo J*. Aurora B maintains spherical shape of mitotic cells via simultaneously stabilizing myosin II and vimentin. 2025. J Mol. Cell Biol., 2025, mjaf023.
6. Liu M, Guo J, Liu W, Yang Z*, Yu F*. Dual Targeting of Aurora-A and Bcl-xL Synergistically Reshapes the Immune Microenvironment and Induces Apoptosis in Breast Cancer. Cancer Sci. 2025 (116)7, 1823-1835.
7. Wang J, Yu W, Shen H, Sang Y, Hang H, Zheng B, Peng X, Hu Y*, Ma X*, Yang Z*, Yu F*. Therapeutic Black Phosphorus Nanosheets Elicit Neutrophil Response for Enhanced Tumor Suppression. 2025. Adv. Sci.. 2025 (12)14: e2414779.
8. Cheng A#, Xu T#, You W, Wang T, Zhang D, Guo H, Zhang H, Pan X, Wang Y, Liu L, Zhang K, Shi J, Yao X, Guo J*, Yang Z*. A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells. Nat. Metab. 2023. 5(7):1141-115.
9. Jiang Y, Wang T, Sheng D, Han C, Xu T, Zhang P, You W, Fan W, Zhang Z, Jin T, Duan X, Yuan X, Liu X, Zhang K, Ruan K, Shi J, Guo J, Cheng A*, Yang Z*. 2022. Aurora A-mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression. J Biol. Chem. 298(11):102561.
10. Cheng A#, Jiang Y#, Wang T, Yu F, Ishrat I, Zhang D, Ji X, Chen M, Xiao W, Li Q, Zhang K, Niu G, Shi J, Pan Y*, Yang Z*, Guo J*. 2021. Energy restriction causes metaphase delay and chromosome mis-segregation in cancer cells. Cell Cycle. 20(12): 1195-1208.
11. Cheng A#, Zhang P#, Wang B#，Yang D#, Duan X, Jiang Y, Xu T, Jiang Y, Shi J, Ding C, Wu G, Sang Z, Wu Q, Wang H, Wu M , Zhang Z, Pan X, Pan Y, Gao P, Zhang H, Zhou C, Guo J* and Yang Z*. 2019. Aurora-A Mediated Phosphorylation of Lactate Dehydrogenase B promotes glycolysis and tumor growth by relieving the substrate inhibition effect. Nat. Commun.2019, 10(1):5566.
12. Yin T#, Zhao ZB#, Guo J#, Wang T, Yang JB, Wang C, Long J, Ma S, Huang Q, Zhang K, Ma X, Liu C, Liu S, Lian ZX*, Yang Z*. 2019. Aurora-A inhibition eliminates myeloid cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in breast cancer. Cancer Res. 2019 10(1):5566.
13. Yu F, Jiang Y, Lu L, Cao M, Qiao Y, Liu X, Liu D, Van Dyke T, Wang F, Yao X, Guo J* and Yang Z*2017. Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B Feedback Loop in late G2 phase. Cell Discovery 3, 16049
招生招聘：实验室招收致力于肿瘤细胞生物学研究的博士后、硕博研究生和本科实习生。
ResearcherID: https://orcid.org/my-orcid?orcid=0000-0001-7797-5891