教授 博士生导师 2001年毕业于北京大学生命科学学院 获理学学士学位 2006年毕业于北京大学生命科学学院 获理学博士学位 2006至2013年 在美国国立卫生研究院（NIH）酒精滥用与酒精中毒研究所（NIAAA）从事博士后研究工作。
2013年3月加入中国科学技术大学生命科学学院。现任生医部副部长兼生命科学学院执行院长。中国科学院“脑科学与脑疾病”重点实验室副主任、“新型生命医学成像与智能处理”安徽省重点实验室主任。国家“杰出青年科学基金”获得者、国家“高层次人才特殊支持计划”科技创新领军人才、科技部“中青年科技创新领军人才”、国家海外高层次人才计划青年项目获得者。中国科学技术大学杰出研究校长奖，中科院优秀导师，唐立新优秀学者奖获得者。从事神经生物学相关科学研究，研究方向包括：脑功能的神经代谢与环路调控、衰老与神经退行性疾病、新型代谢组学技术研发、离子通道调控等。在Cell、Cell Metabolism、Nature Methods、Nature Metabolism、Nature Machine Intelligence、Nature Chemical Biology、Nature Communications、Science Advances、PNAS、Molecular Psychiatry、Science Bulletin等知名国际期刊发表多篇通讯作者论文。工作入选2018年度“中国生命科学十大进展”。主持多项国家级科研项目，包括：科技部“十三五”重点研发计划（首席科学家）、基金委重点项目（负责人）、中科院B类先导科技专项（项目组长）、中科院从0到1原始创新项目（负责人）、863青年科学家等。
研究兴趣与方向：
1.探究感知觉的神经环路机制及其相关疾病，如认知障碍、癫痫、慢性痛、抑郁症、成瘾和耐受等，并开发相应的新型治疗药物和治疗方法。
2.开发新型神经-化学技术，如单细胞质谱、单细胞器质谱、脑质谱成像等。
3.依托单细胞质谱和脑质谱成像技术，研究阿尔兹海默病、帕金森氏病等神经退行性疾病中小分子代谢组的变化及其分子机制，寻找相关的早期诊断标志物以及治疗方法。
4.探索配体门控离子通道的调控机制，如甘氨酸受体和伽马氨基丁酸。
代表性论文：
2. Xiaolin Lian#, Meng Gong#, Zhikai Wang#, Jie Wang#, Weiwei Guo#, Aoling Cai, Zhenye Yang, Xing Liu, Fuqiang Xu, Wei Xiong*, Chuanhai Fu*, Xiangting Wang*. LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination. Cell Discovery, 10(1):54. doi: 10.1038/s41421-024-00667-y. (2024)
3. Weiwei Guo, Wei Xiong*. From gut microbiota to brain: implications on binge eating disorders. Gut Microbes, 16(1):2357177, https://doi.org/10.1080/19490976.2024.2357177 (2024).
4. Qianping Zhang, Tiantian Sun, Fan Yu, Wei Liu, Jin Gao, Jinyu Chen, Hao Zheng, Jinming Liu, Chenjian Miao, Huanyi Guo, Wu Tian, Meihui Su, Yingjie Guo, Xi Liu, Yandong Pei, Zhuofei Wang, Shang Chen, Chenglong Mu, Sin Man Lam, Guanghou Shui, Zongjin Li, Zhongbo Yu, Yan Zhang, Guo Chen, Congcong Lu, Adam C. Midgley, Changhua Li, Xin Bian, Xudong Liao, Yong Wang*, Wei Xiong*, Hongying Zhu*, Yanjun Li* & Quan Chen*. PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury. Nature Chemical Biology, 20(7): 835-846. (2024)
5. Sijia Fan, Weiwei Guo, Dan Xiao, Mengyuan Guan, Tiepeng Liao, Sufang Peng, Airong Feng, Ziyi Wang, Hao Yin, Min Li*, Jue Chen*, Wei Xiong*. Microbiota-Gut-Brain Axis Drives Overeating Disorders.Cell Metabolism, 35(11):2011-2027.e7. (2023)
6. Ziyi Wang, Hongying Zhu*, Wei Xiong*. Advances in mass spectrometry-based multi-scale metabolomic methodologies and their applications in biological and clinical investigations. Science Bulletin, 68: 2268-2284 (2023)
7. Jing Xia, Dan Xiao, Heyi Luo, Jin Jin, Siyuan Ge, Xianglian Wang, Guichang Zou*, Wei Xiong*. The cannabinoid dehydroxylcannabidiol suppresses neuropathic pain by upregulating a spinal glycine receptor-mediated compensation mechanism. Journal of Biological Chemistry, 299(6): 104769 (2023)
8. Tiepeng Liao, Zihao Ren, Zhaoliang Chai, Man Yuan, Chenjian Miao, Junjie Li, Qi Chen, Zhilin Li, Ziyi Wang, Lin Yi, Siyuan Ge, Wenwei Qian, Zilei Wang, Wei Xiong*, Hongying Zhu*. A super-resolution strategy for mass spectrometry imaging via transfer learning. Nature Machine Intelligence, 5: 656–668 (2023)
9. Yiwen Hou#, Guichang Zou#, Xianglian Wang, Hui Guo, Xiao Ma, Xingyu Cheng, Zhiyong Xie, Xin Zuo, Jing Xia, Huanhuan Mao, Man Yuan, Qi Chen, Peng Cao, Yupeng Yang, Li Zhang, Wei Xiong*. Coordinated activity of a central pathway drives associative opioid analgesic tolerance. Science Advances, 9(6):eabo5627 (2023).
10. Ziyi Wang, Fei Sun, Wei Xiong*. Fat shapes fate: unlock the destiny of a cell with single-cell metabolomics. Life Medicine, 1(3):261-263 (2022).
11. Weiwei Guo#, Sijia Fan#, Dan Xiao, Chen He, Mengyuan Guan, Wei Xiong*. A midbrain-reticulotegmental circuit underlies exaggerated startle under fear emotions. Molecular Psychiatry, 27(12): 4881-4892 (2022)
12. Guichang Zou#, Jing Xia#, Heyi Luo, Dan Xiao, Jin Jin, Chenjian Miao, Xin Zuo, Qianqian Gao, Zhi Zhang, Tian Xue, Yezi You, Ye Zhang, Li Zhang, Wei Xiong*.Combined alcohol and cannabinoid exposure leads to synergistic toxicity by affecting cerebellar Purkinje cells. Nature Metabolism, 4(9):1138–1149 (2022)
13. Weiwei Guo#, Sijia Fan#, Dan Xiao, Hui Dong, Guangwei Xu, Zhikun Wan, Yuqian Ma, Zhen Wang, Tian Xue, Yifeng Zhou, Yulong Li, Wei Xiong*. A Brainstem reticulotegmental neural ensemble drives acoustic startle reflexes. Nature Communications, 12(1), 6403, doi: 10.1038/s41467-021-26723-9 (2021)
14. Hongying Zhu#, Qianqian Li#, Tiepeng Liao#, Xiang Yin, Qi Chen, Ziyi Wang, Meifang Dai, Lin Yi, Siyuan Ge, Chenjian Miao, Wenping Zeng, Lili Qu, Zhenyu Ju, Guangming Huang, Chunlei Cang*, Wei Xiong*. Metabolomic profiling of single enlarged lysosomes. Nature Methods, 18(7):788-798 (2021).
15. Yujun Guo#, Guichang Zou#, Keke Qi, Jin Jin, Lei Yao, Yang Pan, Wei Xiong*. Simvastatin impairs hippocampal synaptic plasticity and cognitive function in mice. Molecular Brain, 14(1): 41 doi: 10.1186/s13041-021-00758-x. (2021)
16. Jin Ye#, Guichang Zou#, Ruichi Zhu, Chao Kong, Chenjian Miao, Mingjie Zhang, Jianchao Li*, Wei Xiong*, Chao Wang*. Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission. Nature Communications, 12(1):297, doi: 10.1038/s41467-020-20624-z. (2021)
17. Lei Yao , Chengyuan Liu, Ning Wang, Feng Du, Sijia Fan, Yujun Guo, Li Zhang, Yang Pan, Wei Xiong*. Cholesterol regulates cannabinoid analgesia through glycine receptors. Neuropharmacology, 177: 108242. doi: 10.1016/j.neuropharm.2020.108242. (2020)
18. Lei Yao, Marta Wells, Xiongwu Wu, Yan Xu, Li Zhang*, Wei Xiong*. Membrane cholesterol dependence of cannabinoid modulation of glycine receptor. FASEB J, 34(8): 10920-10930 (2020)
19. Guichang Zou#, Xin Zuo#, Kai Chen, Yushu Ge, Xiaoqun Wang, Guangwei Xu, Huan Wang, Chenjian Miao, Zhenyu Xu, Shuangshuang Tian, Zhen Wang, Yifeng Zhou, Wei Wei, Guangming Huang, Dan Liu, Wei Xiong*. Cannabinoids Rescue Cocaine-Induced Seizures by Restoring Brain Glycine Receptor Dysfunction. Cell Reports, 30(12): 4209-4219 (2020)
20. Guichang Zou, Jing Xia, Qianqian Han, Dan Liu, WeiXiong*. The synthetic cannabinoid dehydroxylcannabidiol restores the function of a major GABAA receptor isoform in a cell model of hyperekplexia. Journal of Biological Chemistry, 295: 138-145 (2020)
21. Xiaoqun Wang#, Yiwen Hou#, Zhuanghao Hou, Wei Xiong*, Guangming Huang*. Mass Spectrometry Imaging of Brain Cholesterol and Metabolites with Trifluoroacetic Acid-Enhanced Desorption Electrospray Ionization, Analytical Chemistry, 91(4): 2719-2726 (2019)
22. Chengyuan Liu, Keke Qi, Lei Yao, Ying Xiong, Xuan Zhang , Jianye Zang, Changlin Tian, Minggao Xu, Jiuzhong Yang , Zhenkun Lin , Yongmei Lv, Wei Xiong*, Yang Pan*. Imaging of Polar and Nonpolar Species Using Compact Desorption Electrospray Ionization/Postphotoionization Mass Spectrometry. Analytical Chemistry, 91(10): 6616-6623 (2019)
23. Guichang Zou, Qi Chen, Kai Chen, Xin Zuo, Yushu Ge, Yiwen Hou, Tao Pan, Huilin Pan, Dan Liu, Li Zhang, Wei Xiong*. Human Hyperekplexic Mutations in Glycine Receptors Disinhibit the Brainstem by Hijacking GABAA Receptors. iScience, 19: 634-646 (2019)
24. Hongying Zhu#, Ning Wang#, Lei Yao, Qi Chen, Ran Zhang, Junchao Qian, Yiwen Hou, Weiwei Guo, Sijia Fan, Siling Liu, Qiaoyun Zhao, Feng Du, Xin Zuo, Yujun Guo, Yan Xu, Jiali Li, Tian Xue, Kai Zhong, Xiaoyuan Song, Guangming Huang*, Wei Xiong*. Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain. Cell, 173(7): 1716-1727 (2018)
25. Jieping Lu#*, Sijia Fan#, Guichang Zou, Yiwen Hou, Tao Pan, Weiwei Guo, Lei Yao, Feng Du, GE Homanics, Dan Liu, Li Zhang, Wei Xiong*. Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia. Neuropharmacology, 133: 224-232 (2018)
26. Hongying Zhu#, Guichang Zou#, Ning Wang#, Meihui Zhuang, Wei Xiong*, Guangming Huang*. Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry. PNAS, 114(10): 2586-2591 (2017)
27. Wei Xiong, Shao-Rui Chen, Liming He, Kejun Cheng, Yi-Lin Zhao, Hong Chen, De-Pei Li, Gregg E. Homanics, John Peever, Kenner C. Rice, Ling-gang Wu, Hui-Lin Pan & Li Zhang. Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nature Neuroscience, 17: 232-239 (2014)
28. Wei Xiong, Tanxing Cui, Kejun Cheng, Fei Yang, Shao-Rui Chen, Dan Willenbring, Yun Guan, Hui-Lin Pan, Ke Ren, Yan Xu and Li Zhang. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. Journal of Experimental Medicine, 209 (6): 1121-1134 (2012)
29. Wei Xiong, Xiongwu Wu, David M. Lovinger and Li Zhang. A Common Molecular Basis for Exogenous and Endogenous Cannabinoid Potentiation of Glycine Receptors. Journal of Neuroscience, 32 (15): 5200-5208 (2012)
30. Wei Xiong, KeJun Chen, Tanxing Cui, Grzegorz Godlewski, Kenner Rice, Yan Xu and Li Zhang. Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia. Nature Chemical Biology,7: 296-303(2011)
招生招聘：
实验室招聘具备神经生物学、分析化学或分子生物学等相关背景的co-PI、博士后和实验员，待遇从优。同时欢迎本科实习生和报考研究生。
联系方式：
电话：0551-63601736；邮箱：wxiong@ustc.edu.cn；
通讯地址：安徽省合肥市蜀山区中国科学技术大学西校区科技楼917
实验室网页：http://x-lab.ustc.edu.cn/