胡兵

胡兵

2022-09-20来源:生命科学学院



胡兵,教授,博导,中科大生命科学实验中心主任中国科学技术大学生物学系生物物理学专业学士(1984-1989)硕士(1989-1992),中国科学院上海生理研究所博士(1993-1999,香港大学医学院联合培养1994-1997)2001年在香港大学医学院解剖学系以及2002.1-2004.11在美国加州大学(UCLA&UCIrvine) 开展博士后工作。20078香港大学医学院解剖学系Research Officer曾任安徽省生理学会副理事长,现任监事长;安徽省神经科学学会常务理事。科技部重点研发生物技术领域评专家,国自然港澳合作基金评审专家


多年从事发育神经生物学和神经损伤及髓鞘修复机制的研究,发表SCI论文82, 参编英文专著三个章节,理论教科书两个章节,实验教科书一个章节,第一共笫一作者8,通讯共通讯作者共计52篇,总计被引2700次。第一和共第一作者及通讯作者代表性论文有Glia, Development, Nature Medicine, Advanced Materials, ACS Nano,IOVSJ Pineal Res,Am J Hum Genet.Adv Func Mat.Nucleic Acids Res,FASEB J, Acta Neuropathologica CommunicationsCellular and Molecular Life Sciences。曾获得1997中科院自然科学二等2007-2008年度香港大学最佳研究著作奖2009年第三届药明康德生命化学研究奖,王宽诚育才奖(20002013,安徽省首届大学生科普创意大赛一等奖指导导师(2010),中国科学技术大学第八届杨亚基金教育奖2015),安徽省教学成果一等奖(2018),中国科学技术大学公共实验中心突出贡献奖(2023以学术骨干身份完成国家科技部973项目和重点研发项目3项,先后负责承担并完成国家自然科学基金面上5项、重大研究计划培育项目21项重大子课题,正在承担合肥大健康研究重点1


主要研究兴趣:
1.
斑马鱼神经元及其髓鞘损伤保护机制修复对策
2.
在位实时活体成像技术应用于神经发育损伤修复细胞分子动力学的研究

3. 神经细胞转录组蛋白组学技术应用于斑马鱼Mauthner神经再生。


主要研究课题:斑马鱼运动神经单细胞解析神经再生斑马鱼髓鞘再建


主要代表论文:

Cui J#, Shen Y#, Song Z, Fan D, Hu B* (2025) Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons. Neural Regen Res  20(6):1816-1824

Zheng Song, Along Han and Bing Hu* (2024) Thymosin β4 promotes zebrafish Mauthner axon regeneration by facilitating actin polymerization through binding to G actin.BMC Biology. 22(1):244

Xinghan Chen, Yueru Shen, Zheng Song, Xinliang Wang, Huaitong Yao, Yuan Cai, Ziang Zhao, Bing Hu* (2024) microRNA-2184 orchestrates Mauthner-cell axonal regeneration in zebrafish via syt3 modulation. Journal of Genetics and Genomics.  51(2024):011-021. https://doi.org/10.1016/j.jgg.2024.03.016.

Yueru Shen1Xinghan Chen1Zheng Song1Huaitong Yao1Along Han1Yawen Zhang1Yuan Cai3Bing Hu*1,2 (2024) MicroRNA 9 promotes axon regeneration of mauthner cell in zebrafish via her6/ calcium activity pathway.Cellular and Molecular Life Sciences  81:104

Rongchen Huang, Yang Xu, Min Chen, Leiqing Yang, Xinliang Wang, Yueru Shen, Yubin Huang and Bing Hu* (2022) Visualizing the Intracellular Trafficking in Zebrafish Mauthner Cells (chapter 18)in Book “Axonal Transport”  Methods and Protocols edited by Vagnoni, Alessio (section editor),Springer Nature publisher. ISBN 978-1-0716-1989-6

Chen M, Huang RC, Yang LQ, Ren DL*, Hu B*(2019) In vivo imaging of evoked calcium responses indicates the intrinsic axonal regenerative capacity of zebrafish.FASEB J. 33(6):7721-7733.

Hu BB, Chen M, Huang RC, Huang YB, Xu Y, Yin W, Li L and Hu B* (2018) In vivo imaging of mauthner axon regeneration, remyelination and synapses re-establishment after laser axotomy in zebrafish larvae. Exp Neurol. 300:67-73. 2018. Feb. https://doi.org/10.1016/j.expneurol.2017.10.028

Tian CZou SHu B*(2016) Extraocular Source of Oligodendrocytes Contribute to Retinal Myelination and Optokinetic Responses in Zebrafish. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):2129-38. doi: 10.1167/iovs.15-17675. (highlight in the same issue)

Da-Long Ren, Ai-Ai Sun, Ya-Juan Li, Min Chen, Shu-Chao Ge and Bing Hu* (2015) Exogenous melatonin inhibitsneutrophil migration throughsuppression of ERK activation. Journal of Endocrinology. 227(1) :49–60. DOI: 10.1530/JOE-15-0329. Epub 2015 Aug 24. (cover page)

Da-long Ren, Ya-juan Li, Bing-bing Hu, Han Wang* and Bing Hu* (2015)

Melatonin regulates the rhythmic migration of neutrophils in live zebrafish. J Pineal Res., 2015 May;58(4):452-60. doi: 10.1111/jpi.12230. Epub 2015 Mar 26.

Sha Mi*, Bing Hu*, Kyungmin Hahm, Yi Luo, Edward Sai Kam Hui, Qiuju Yuan, Wai Man Wong, Li Wang, Huanxing Su, Tak-Ho Chu, Jiasong Guo, Wenming Zhang, Kwok-Fai So, Blake Pepinsky, Zhaohui Shao, Christilyn Graff, Ellen Garber, Vincent Jung, Ed Xuekui Wu & Wutian Wu* (2007) LINGO-1 antagonist promotes spinal cordremyelinationand axonal integrity in MOG-induced experimentalautoimmune encephalomyelitis. Nature Medicine. 13(10):1228-1233. (cover page)

Bing Hu, Angeliki Maria Nikolakopoulou and Susana Cohen-Cory (2005) BDNF stabilizes synapses and maintains the structural complexity of optic axons in vivo. Development. 132:4285-4298.

Bing Hu, Henry K. Yip and Kwok-Fai So (1998) Localization of p75 neurotrophin receptor in the retina of the adult SD rat: An immunocytochemical study at light and electron microscopic levels. Glia 24:187-197.


联系方式:Email: bhu@ustc.edu.cn 

联系电话:63602489office63607014Lab

Lab Websitehttp://222.195.69.43/hub/

Researcher ID pagehttp://www.researcherid.com/rid/B-1030-2010

Research ID: B-1030-2010

ORCID page: https://orcid.org/0000-0001-8627-5272

ORCID 0000-0001-8627-5272


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