刘强

刘强

2022-01-13来源：生命科学学院


个人介绍：

讲席教授，国家杰出青年科学基金获得者（2021），国家创新人才计划（2012），国家优秀青年科学基金获得者（2014）。在华盛顿大学医学院和宾夕法尼亚大学医学院完成博士后研究后回国，长期从事脑衰老，神经退行性疾病以及代谢调控等方面的研究工作。近年来取得了一系列重要研究成果，发表于Cell, Cell Metabolism, Neuron, Immunity, Nature Structural & Molecular Biology等国际学术期刊。得到国家自然科学基金重点项目，科技部重点研发计划，中科院战略先导科技专项等项目支持。兼任合肥微尺度物质科学国家研究中心脑认知研究部主任，衰老生物医学安徽省重点实验室主任。


主要研究兴趣:

1. 脑衰老和阿尔茨海默病的分子细胞机制探索；

2. 大脑脂代谢在神经退行性疾病以及衰老过程中的作用机制研究；

3. 表观遗传调控在学习记忆中的作用机制解析。



代表性研究论文：

  1. Li D, Gao X, Ma X, Wang M, Cheng C, Xue T, Gao F, Shen Y, Zhang J, Liu Q. Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization. Cell Metabolism 36: 1-17, 2024.

  2. Li XH, Zhang J, Li DF, He C, He K, Xue T, Wan L, Zhang C and Liu Q. Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone acetylation-mediated memory. Neuron 109:1-14, 2021.

  3. Li D, Cao R, Li Q, Yang Y, Tang A, Zhang J, Liu Q. Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment. Nature Structural & Molecular Biology. 30:914-925, 2023.

  4. Zhang J, Liu Q. Shedding light on interventions for brain aging. Immunity59(2):235-237, 2026.

  5. Li D, Zhang J, Liu Q. Brain cell type-specific cholesterol metabolism and implications for learning and memory. Trends in Neurosciences 45:401-414, 2022.

  6. Li D, Zhang J, Wang M, Li X, Gong H, Tang H, Chen L, Wan L and Liu Q. Activity dependent LoNA Regulates Translation by Coordinating rRNA Transcription and Methylation. Nature Communications 9（1）：1726，2018.

  7. Zhang Q, Zhang J, Ye J, Li X, Liu H, Ma X, Wang C, He K, Zhang W, Yuan J, Zhao Y, Xu H, Liu Q. Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing. Molecular Neurodegeneration 16(1):66, 2021.

  8. Raihan O, Brishti A, Li Q, Zhang Q, Li D, Li X, Zhang Q, Xie Z, Li J, Zhang J, Liu Q. SFRS11 loss leads to aging-associated cognitive decline by modulating LRP8 and ApoE. Cell Reports 28(1):78-90, 2019.

  9. Berg MG, Singh LN, Younis I, Liu Q, Pinto AM, Kaida D, Zhang Z, Cho S, Sherrill-Mix S, Wan L, Dreyfuss G. U1 snRNP Determines mRNA Length and Regulates Isoform Expression. Cell 150: 53-64, 2012.

  10. Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, Herz J, Muglia L, Bu G. Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1. Neuron56:66-78, 2007.

  11. Jin S, Lu W, Zhang J, Zhang L, Tao F, Zhang Y, Hu X, Liu Q. The mechanisms, hallmarks, and therapies for brain aging and age-related dementia. Science Bulletin. 69(23):3756-3776, 2024.

  12. Ma Y, Zhang J, Liu H, Li D, Guo S, Han J, Wang L, Yu S, Su X, Gao Y, Lin X, San A, Peng Y, Li G, Jiang H, Wang W, Yang H, Wang J, Zhu S, Zhao L, Zhang J, Liu Q. Spatiotemporal characterization of disease-associated neurons in the entorhinal cortex-hippocampal circuit during AD progression. Protein & Cell. 16(9): 799–814，2025.

联系方式：liuq2012@ustc.edu.cn

联系电话：0551-63601179