主要研究兴趣:
1,与心脏疾病相关的受体和离子通道蛋白(主要是钾离子通道)的结构与功能研究。
2,综合应用分子生物学、电生理膜片钳技术阐述通道蛋白受调控(包括辅助亚基调控、天然毒素调控等)的结构与功能机制。
博士,副教授。2006年毕业于中国科学技术大学生命科学学院,获理学博士学位。其后赴美国马里兰大学医学院生理系从事博士后工作,研究内源性大麻素在生理和病理条件下起作用的神经机制。2011年2月作为中国科学技术大学优秀人才引进,现任生命科学学院副教授。主要研究成果发表于JNS,Plos One,PNAS,Neuropsychopharmacology等国际学术期刊。
主要代表性论文:
1.Pan Li, Haowen Liu, Chaohua Lai, Peibei Sun, Wenping Zeng, Fangming Wu, Longhua Zhang, Sheng Wang*, Changlin Tian*, Jiuping Ding*. Differential Modulations of KCNQ1 by Auxiliary Proteins KCNE1 and KCNE2. Sci Rep 2014;4: 4973
2.Man Pan, Yao He, Ming Wen, Fangming Wu, Demeng Sun, Sijian Li, Longhua Zhang*, Yiming Li*, Changlin Tian*. One-pot hydrazide-based native chemical ligation for efficient chemical synthesis and structure determination of toxin Mambalgin-1. Chem Commun 2014;50(44): 5837-39
3.Mu Yu, Peibei Sun, Yao He, Liang Xiao, Demeng Sun, Longhua Zhang*, Changlin Tian*. Mutation of the critical pH-gating residues histidine 231 to glutamate increase open probability of outer membrane protein G in planar lipid bilayer. Protein Cell2013; 4(11): 803-6
4.Longhua Zhang, Meina Wang, Tiziana Bisogno, Vincenzo Di Marzo,Bradley E. Alger.Endocannabinoids generated by Ca2+ or by metabotropic glutamate receptors appear to arise from different pools of diacylglycerol lipase. PLoS One 2011; 6(1):e16305.
5.Longhua Zhang, Bradley E. Alger.Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome. J Neurosci 2010; 30(16):5724-9.
6. David A. Edwards, Longhua Zhang, Bradley E. Alger. Metaplastic control of the endocannabinoid system at inhibitory synapses in hippocampus. Proc Natl Acad Sci U S A 2008; 105(23): 8142-8147.
7. Longhua Zhang, Neng Gong, Da Fei, Lin Xu, Tian-Le Xu.Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. Neuropsychopharmacology 2008; 33(3): 701-711.
8. Longhua Zhang, Lin Xu, Tian-Le Xu.Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats. Biochem Biophys Res Commun 2006; 344(3): 721-726.
联系方式:
Email: zlhustc@ustc.edu.cn;
电话:0551-63607001
Hmepage: http://staff.ustc.edu.cn/~zlhustc