研究方向： 

1. 蛋白质-核酸相互作用关系的结构基础

2. 金黄色葡萄球菌生物被膜形成的调控机制

3. 蓝藻代谢通路改造及工业应用

4. 酶的发现、改造及工业应用

博士，副教授。

长期从事生物化学和结构生物学的教学和科研工作，通过研究蛋白质及其复合物的结构-功能关系，阐明其催化机制和相互作用关系的基础，并尝试对蛋白质功能进行设计及改造。先后主持和参与了十余项科技部、国际自然科学基金委、中国科学院和安徽省的重要课题研究工作。在PNAS、Nucleic Acids Research、ACS Catalysis、和Journal of Biological Chemistry等学术刊物发表相关研究成果70余篇。

学习经历：

工作经历： 

研究项目：

国家基础研究计划项目(973): 2012CB917202; 2009CB825502

国家自然科学基金项目: 31971124; U1732114; 31270014; 30900224

省部级项目：1308085JGD08; 10040606Y11; 090413081; 2009SQRZ007ZD

代表性论文：

1. Wang M, Guo Q, Zhu K, Fang B, Yang Y, Teng M, Li X*, Tao Y*. (2020) Interface switch mediates signal transmission in a two-component system. Proc Natl Acad Sci U S A. 117(48):30433-30440. (共通讯作者)

2. Yu S, Shen H, Cheng Y, Zhu Y, Li X*, Mu W* (2018) Structural and Functional Basis of Difructose Anhydride III Hydrolase, Which Sequentially Converts Inulin Using the Same Catalytic Residue. ACS Catalysis 8: 10683-10697. (共通讯作者)

3. Liu Z, Chen P, Wang X, Cai G, Niu L, Teng M*, Li X*. (2014) Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode. Nucleic Acids Res. 42(14):9470-83. (共通讯作者)

4. Shao Z, Yan W, Peng J, Zuo X, Zou Y, Li F, Gong D, Ma R, Wu J, Shi Y, Zhang Z, Teng M, Li X*, Gong Q*. (2014) Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res. 42(1):509-25. (共通讯作者)

5. Wang Z, Shen H, He B, Teng M*, Guo Q*, Li X*. (2021) The structural mechanism for the nucleoside tri- and di-phosphate hydrolysis activity of Ntdp from Staphylococcus aureus. FEBS J. doi: 10.1111/febs.15911. (共通讯作者)

6. Jiang X, Zhang L, An J, Wang M, Teng M*, Guo Q*, Li X* (2020) Caulobacter crescentus β sliding clamp employs a noncanonical regulatory model of DNA replication. FEBS J. 287(11):2292-2311. (共通讯作者)

7. Jiang X*, Zhang L, Teng M, Li X* (2020) Antibiotic binding releases autoinhibition of the TipA multidrug-resistance transcriptional regulator. J Biol Chem. 295(51):17865-17876. (共通讯作者)

8. Zhang W, Zeng F, Liu Y, Zhao Y, Lv H, Niu L, Teng M*, Li X*. (2013) Crystal structures and RNA-binding properties of the RNA recognition motifs of heterogeneous nuclear ribonucleoprotein L: insights into its roles in alternative splicing regulation. J Biol Chem. 288(31):22636-49. (共通讯作者)

9. Wang Q, Bian X, Zeng L, Pan F, Liu L, Liang J, Wang L, Zhou K, Lee W, Xiang Y, Li S, Teng M, Li X*, Guo X*, Zhang Y*. (2020) A cellular endolysosome-modulating pore-forming protein from a toad is negatively regulated by its paralog under oxidizing conditions. J Biol Chem. 295(30):10293-10306. (共通讯作者)

10. Zhu Y, Wu B, Zhang X, Fan X, Niu L, Li X*, Wang J*, Teng M*. (2015) Structural and biochemical studies reveal UbiG/Coq3 as a class of novel membrane-binding proteins. Biochem J. 470(1):105-14. (共通讯作者)

联系方式： 

邮箱：sachem@ustc.edu.cn

Tel: 86 551 63607334