梅一德，教授，博士生导师。2000年毕业于安徽大学生命科学学院，获理学学士学位；2002年至2007年，就读于中国科学技术大学生命科学学院，获博士学位。2007年至2011年于美国宾夕法尼亚大学医学院从事博士后研究。2011年至今，任中国科学技术大学生命科学学院教授。主要研究癌蛋白和抑癌蛋白的调控机制以及微环境在肿瘤发生发展中的作用，以期深入地解析肿瘤发生发展的信号网络，并鉴定肿瘤治疗新的潜在靶点。主要研究成果发表于Molecular Cell，Nature Structural & Molecular Biology，PNAS，Nature Communications，EMBO Journal和Cancer Research等国际学术期刊。2013年入选教育部新世纪优秀人才支持计划，2014年获得国家自然科学基金委“优秀青年科学基金”项目。
主要研究兴趣：
1．蛋白质翻译后修饰与肿瘤发生发展；
2．代谢和免疫微环境与肿瘤发生发展；
3．非编码RNA与肿瘤发生发展。
代表性学术论文（* 通讯作者）：
1. Kailiang Zhao#, Hao Hu#, Debao Fang#, Mingran Xie#, Jiasheng Chen, Shan Zhang, Suyun Tang, Mingsheng Wu, Xiaorui Guo, Ning Yu, Bo Yao, Wenli Jiang, Chao Wang and Yide Mei* Akt-phosphorylated UFL1 UFMylates ArpC4 to promote metastasis. Nature Structural & Molecular Biology 32: 1528-1541. (2025)(Highlighted in News & Views in Nature Structure & Molecular Biology)
2. Yang Yang#, Jingjing Luo#, Zhongyu Wang, Kaiyue Liu, Keyi Feng, Fang Wang* and Yide Mei* Energy stress-induced circEPB41(2) promotes lipogenesis in hepatocellular carcinoma. Cancer Research 85: 723-738. (2025)
3. Hao Hu#, Kailiang Zhao#, Debao Fang#, Zhongyu Wang, Ning Yu, Bo Yao, Kaiyue Liu, Fang Wang and Yide Mei* The RNA binding protein RALY suppresses p53 activity and promotes lung tumorigenesis. Cell Reports 42: 112288. (2023)
4. Debao Fang#, Hao Hu#, Kailiang Zhao#,*, Aman Xu, Changjun Yu, Yong Zhu, Ning Yu, Bo Yao, Suyun Tang, Xianning Wu and Yide Mei* MLF2 negatively regulates p53 and promotes colorectal carcinogenesis. Advanced Science 10: e2303336. (2023)
5. Chenfeng Wang#, Yang Yang#, Xianning Wu#, Jingxin Li, Kaiyue Liu, Debao Fang, Bingyan Li, Ge Shan, Xinyu Mei*, Fang Wang* and Yide Mei* Reciprocal modulation of long noncoding RNA EMS and p53 regulates tumorigenesis. Proc Natl Acad Sci U S A 119: e2111409119. (2022)
6. Guang Zhang#, Yang Yang#, Hao Hu, Kaiyue Liu, bingyan Li, Yu Zhu, Zhongyu Wang,Qingfa Wuand Yide Mei*Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis. Oncogene 40: 2936-2951.(2021)
7. Kailiang Zhao, Decai Wang, Xiaolong Zhao, Chenfeng Wang, Yongxiang Gao, Kaiyue Liu, Fang Wang, Xianning Wu, Xuejuan Wang, Linfeng Sun, Jianye Zang and Yide Mei* WDR63 inhibits Arp2/3-dependent actin polymerization and mediates the function p53 in suppressing metastasis. EMBO Reports 21: e49269. (2020)
8. Chenfeng Wang#, Yang Yang#, Guang Zhang, Jingxin Li, Xianning Wu, Xiaoling Ma, Ge Shan and Yide Mei* Long non-coding RNA EMS connects c-Myc to cell cycle control and tumorigenesis. Proc Natl Acad Sci U S A 116: 14620-14629 (2019)
9. Kailiang Zhao, Yang Yang, Guang Zhang, Chenfeng Wang, Decai Wang, Mian Wu* and Yide Mei* Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7. EMBO Reports 19: 305-319. (2018)
10. Yang Yang, Chenfeng Wang, Kailiang Zhao, Guang Zhang, Decai Wang and Yide Mei* TRMP, a p53-inducible long noncoding RNA, regulates G1/S cell cycle progression by modulating IRES-dependent p27 translation. Cell Death & Disease 9: 886. (2018)
11. Hao Gu, Qidong Li, Shan Huang, Weiguang Lu, Fangyuan Cheng, Ping Gao, Chen Wang, Lin Miao*, Yide Mei* and Mian Wu*. Mitochondrial E3 ligase March5 maintains stemness of mouse ES cells via suppression of ERK signalling. Nat Commun 6: 7112. (2015)
12. Fan Yang, Huafeng Zhang, Yide Mei* and Mian Wu*. Reciprocal regulation of HIF-1α and lincRNA-p21 modulates the Warburg effect. Mol Cell 53: 88-100. (2014) (Highlighted in Science Signaling)
13. Xingwu Wang, Meng Zha, Xiaocheng Zhao, Peng Jiang, Wenjing Du, Andrew Y.H. Tam, Yide Mei* and Mian Wu*. Siva1 inhibits p53 function by acting as an E3 ubiquitin ligase of ARF. Nat Commun 4: 1551. (2013)
14. Xing Huang, Zhengsheng Wu, Yide Mei* and Mian Wu*. XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling. EMBO J 32: 2204-16. (2013)(Previewed in this issue)
15. Xingwu Wang, Xiaocheng Zhao, Xiang Gao, Yide Mei* and Mian Wu*. A new role of p
16. Yide Mei#, Jeongsik Yong#, Hongtu Liu, Yigong Shi, Judy Meinkoth, Gideon Dreyfuss and Xiaolu Yang. tRNA binds to cytochrome c and inhibits caspase activation. Mol Cell 37: 668-78. (2010) (Cover story; Previewed in this issue; Highlighted in Science Signaling and Chemical & Engineering News)
联系方式：meiyide@ustc.edu.cn；科大西区医算楼632/635室
联系电话：0551-63600921（办公室）0551-63601270（实验室）
Research ID：http://www.researcherid.com/rid/M-4468-2013