教授 博士生导师 国家杰出青年基金 首批新世纪百千万人才工程国家级人选”和国务院政府特殊津贴获得者。历任中国生物物理学会常务理事、分子生物物理分会主任、中国晶体学会常务理事、中国生物化学与分子生物学学会理事、中科院生物物理研究所副所长、生物大分子国家重点实验室副主任。主要从事以蛋白质结构与功能关系为核心的结构生物学研究。
主要研究方向：
1）光能转换和气味感应蛋白。2）在研究蛋白质构象变化的基础上，结合化学生物学技术研发新型生物感受器和体外诊断试剂。
近期代表性论文:
1). Y Wang, X Han, F Wu, J W.Leung, M G.Lowery, H Do, J Chen, C Shi, C Tian*, L Li*, W Gong*. Structure Analysis of FAAP24 Reveals Single Stranded DNA Binding Activity and Domain Functions in DNA Damage Response. Cell Res. 2013 Oct;23(10):1215-1228. doi: 10.1038/cr.2013.124. Epub 2013 Sep 3.
2). W sun,Y Zhu, Z Wang, Q Zhong, F Gao, J Lou, W Gong*,W Xu*. Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations. Nat Commun. 2013 Jul 16;4:2135. doi: 10.1038/ ncomms3135.
3). W Sun, F Gao, H Fan, X Shan, R Sun, L Liu*, W Gong*.The structures of Arabidopsis Deg5 and Deg8 reveal new insights into HtrA proteases. Acta Crystallogr D Biol Crystallogr. 2013 May;69(Pt 5):830-7. doi: 10.1107/S0907444913002023. Epub 2013 Apr 11.
4) . F Li, P Shi, J Li, F Yang, T Wang, W Zhang, F Gao, W Ding, D Li, J Li, Y Xiong, J Sun, W Gong*, C Tian, J Wang*.A genetically encoded 19F NMR probe for tyrosine phosphorylation. Angew Chem Int Ed Engl. 2013 Apr 2;52(14):3958-62. doi: 10.1002/anie.201300463.
5). X Liu , C Niu , J Ren , J Zhang , X Xie , H Zhu* , W Feng* , W Gong*. The RRM domain of human fused in sarcoma protein reveals a non-canonical nucleic acid binding site. Biochim Biophys Acta（Molecular Basis of Disease）, 2013 Feb;1832(2):375-85. doi:10.1016 /j.bbadis. 2012.11.012. Epub 2012 Nov 28.
6). C Niu, J Zhang, F Gao, L Yang, M Jia, H Zhu*, W Gong*. FUS-NLS/Transportin 1 complex structure provides insights into the nuclear targeting mechanism of FUS and the implications in ALS. Plos One. 2012;7(10):e47056. Epub 2012 Oct 8.
7). D Zhang, G Liu, J Xue, J Lou, KH Nierhaus, W Gong*,Y Qin*. Common chaperone activity in the G-domain of trGTPase protects L11–L1 interaction on the ribosome. Nucleic Acids Res. 2012 Nov 1;40(21):10851-65. doi: 10.1093/nar/gks833. Epub 2012 Sep 10.
8). R Sun, H Fan, F Gao, Y Lin, L Zhang, W Gong*, L Liu*.Crystal structure of Arabidopsis Deg2 reveals an internal PDZ ligand locking the hexameric resting state. J Biol Chem. 2012 Oct 26;287(44):37564-9.
9). X Liu, J Li, J Dong, C Hu, W Gong*,J Wang*.Genetic incorporation of a metal-chelating amino acid as a probe for protein electron transfer. Angew Chem Int Ed Engl. 2012 Oct 8;51(41):10261-5. Epub 2012 Aug 31.
10). X Wang, J Xue, Z Sun, Y Qin*, W Gong*. Study on the chaperone properties of conserved GTPases. Protein & Cell, 2012, 3(1):44-50.
11). L Sun, M Wang, Z Lv, N Yang, Y Liu, S Bao, W Gong* & R Xu*.Structural insights into protein arginine symmetric dimethylation by PRMT5. PNAS,2011 Dec 20;108(51):20538-43. Epub 2011 Dec 5.
联系方式：
电话：0551-63603819
E-mail：wgong@ustc.edu.cn