主要研究方向（招生专业）及内容
临床医学
1）移植排斥免疫反应信号通路研究；
2）移植术后病人个体化免疫抑制策略研究；
3）肝胆胰外科及肝移植外科临床及基础研究；
博士生导师 教授 器官移植中心主任
一、学习及工作经历
1986年 德国杜塞尔多夫大学医学院 医学博士
1987年--1994年，汉诺威医学院，历任科研助理，讲师
汉诺威医学院腹部外科和器官移植中心，历任住院医、主治医师
1994年--2003年，汉诺威医学院，历任外科学副教授，教授，
汉诺威医学院腹部外科和器官移植中心，历任副主任医师，多器官移植项目主任
2003年--2007年，加拿大达尔豪斯大学，教授，多器官移植项目主任
2004年 加拿大皇家外科学院院士
2005年 美国外科学院院士
2011年 欧洲外科委员会荣誉会员
2007年--2017年，汉堡大学附属医院，肝胆外科、器官移植外科主任
2017年至今，中国科学技术大学附一院，器官移植中心主任
二、学术成果及影响
此前担任德国汉堡大学附属医院肝胆外科、器官移植中心主任以及德国移植协会主席，现为美国外科学院院士、加拿大皇家外科学院院士，欧洲外科委员会荣誉会员，在包括NEJM、Lancet等在内的国际权威杂志上发表论文百余篇，促进了相关学科的发展。
三、在研项目(仅限于主要负责人)
中国科大“新医学”创新团队基金：机械灌注下器官维护和修复多学科器官移植团队
起止日期：2019 – ongoing
四、代表性论文（近五年）
Janssen M, Thaiss F, Nashan B, Koch M, Thude H. | Donor derived HLA-G polymorphisms have a significant impact on acute rejection in kidney transplantation. Hum Immunol. 2019 Jan 2. pii: S0198-8859(18)30649-9. doi: 10.1016/j.humimm.2018.12.011 | 2019 |
Thude H, Tiede P, Sterneck M, Nashan B, Koch M. | Impact of TBX21, GATA3, and FOXP3 gene polymorphisms on acute cellular rejection after liver transplantation.HLA. 2019 Jan 7. doi: 10.1111/tan.13458. | 2019 |
Sommerer C, Suwelack B, Schenker P, Hauser I, Witzke O, Hugo Ch, Kamar N, Mervielle P, Junge M, Thaiss F, Nashan B | An open-label, randomized trial indicates that everolimus with tacrolimus or cyclosporine is comparable to standard immunosuppression in de novo kidney transplant patients. Kidney International 2019 Feb 27 https://doi.org/10.1016/j.kint.2019.01.041 | 2019 |
Del Pino S, Fischer L, Nashan B, Li J. | Dig Surg. 2019 Feb 27:1-6. doi: 10.1159/000497453. PMID:30814481 | 2019 |
Herden U, Schoening W, Pratschke J, Manekeller S, Paul A, Linke R, Lorf T, Lehner F, Braun F, Stippel DL, Sucher R, Schmidt H, Strassburg CP, Guba M, van Rosmalen M, Rogiers X, Samuel U, Schön GM, Nashan B. | Can J Gastroenterol Hepatol. 2019 Mar 5;2019:8747438. doi: 10.1155/2019/8747438. eCollection 2019. PMID:30949459 | 2019 |
Song W, Wang J, Liu H, Zhu C, Xu F, Qian L, Shen Z, Zhu J, Yin S, Qin J, Chen L, Wu D, Nashan B, Shan G, Xiao W, Zhou Y. | Cytokine. 2019 May 11;120:165-175. doi: 10.1016/j.cyto.2019.05.004. PMID: 31085454 | 2019 |
Spetzler VN, Schepers M, Pinnschmidt HO, Fischer L, Nashan B, Li J. | Hepatobiliary Surg Nutr. 2019 Apr;8(2):101-110. doi: 10.21037/hbsn.2019.02.06. PMID:31098357 | 2019 |
Martrus G, Goebels H, Langeneckert AE, Kah J, Flomm F, Ziegler AE, Niehrs A, Löbl SM, Russu K, Hess LU, Salzberger W, Poch T, Nashan B, Schramm C, Oldhafer KJ, Dandri M, Koch M, Lunemann S, Altfeld M | CD49a Expression Identifies a Subset of Intrahepatic Macrophages in Humans. Front Immunol. 2019 Jun 7;10:1247. doi: 10.3389/fimmu.2019.01247 | 2019 |
Koch M, Kroencke S, Li J, Wiessner C, Nashan B. | Structured introduction of retroperitoneoscopic donor nephrectomy provides a high level of safety and reduces the physical burden for the donor compared to an anterior mini incision: A cohort study. Int J Surg. 2019 Aug 7;69:139-145. doi: 10.1016/j.ijsu.2019.07.038. | 2019 |
Deuse T, Hu X, Agbor-Enoh S, Koch M, Spitzer MH, Gravina A, Alawi M, Marishta A, Peters B, Kosaloglu-Yalcin Z, Yang Y, Rajalingam R, Wang D, Nashan B, Kiefmann R, Reichenspurner H, Valantine H, Weissman IL, Schrepfer S. | De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans. Nat Biotechnol. 2019 Aug 19. doi: 10.1038/s41587-019-0227-7. | 2019 |
Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22) Gene Polymorphisms in Liver Transplant Donors and Impact on Acute Cellular Liver Transplant Rejection. HLA
| 2019 | |
Li J, Moustafa M, Freiwald-Bibiza E, Alzudjali A, Fischer L, Nashan B. | J Gastrointest Surg. 2019 Dec 2. doi: 10.1007/s11605-019-04457-w. | 2019 |
Zhou Q, Zhu C, Shen Z, Zhang T, Li M, Zhu J, Qin J, Xie Y, Zhang W, Chen R, Wang G, Qian L, Wu D, Nashan B, Zhou Y. | Eur J Surg Oncol. 2020 May;46(5):855-861. doi: 10.1016/j.ejso.2020.01.026. Epub 2020 Jan 20. | 2020 |
Thude H, Onken L, Kappauf J, Dworak M, Sterneck M, Peine S, Nashan B, Koch M. | HLA. 2020 Apr 5. doi: 10.1111/tan.13892. | 2020 |
Ning L, Liu L, Li W, Liu H, Wang J, Yao Z, Zhang S, Zhao D, Nashan B, Shen A, Liu L, Li L. | Novel Coronavirus (SARS-CoV-2) Infection in A Renal Transplant Recipient: Case Report. Am J Transplant. 2020 Apr 10. doi: 10.1111/ajt.15897. | 2020 |
Su X, Shang W, Liu L, Li J, Fu Q, Feng Y, Zhang H, Deng R, Wu C, Wang Z, Pang X, Nashan B, Feng G, Wang C | Transplantation of a single kidney from pediatric donors less than 10 kg to children with poor access to transplantation: a two-year outcome analysis. BMC Nephrol. 2020 Jul 2;21(1):250. doi: 10.1186/s12882-020-01895-6.PMID: 32616005 | 2020 |
Guo Y, Zhu Z, Wu W, Huang D, Zheng H, Xu Z, Li X, Wang N, Qin J, Liu Y, Liu L, Nashan B. | Liver Transplantation in a Patient With Acute-on-Chronic Liver Failure Due to Traditional Chinese Medicine Intoxication Using Donation After Circulatory Death From a Renal Transplant Recipient: A Case Report. Transplant Proc. 2020 Nov;52(9):2813-2816. doi: 10.1016/j.transproceed.2020.08.003. Epub 2020 Sep 6.PMID: 32900476 | 2020 |
Thude H, Tiede P, Sterneck M, Peine S, Nashan B, Koch M. | CD28 gene polymorphisms and acute cellular rejection after liver transplantation. Hum Immunol. 2020 Dec;81(12):675-678. doi: 10.1016/j.humimm.2020.10.002. Epub 2020 Oct 20.PMID: 33097290 | 2020 |
Voß H, Wurlitzer M, Smit DJ, Ewald F, Alawi M, Spohn M, Indenbirken D, Omidi M, David K, Juhl H, Simon R, Sauter G, Fischer L, Izbicki JR, Molloy MP, Nashan B, Schlüter H, Jücker M. | Differential regulation of extracellular matrix proteins in three recurrent liver metastases of a single patient with colorectal cancer. Clin Exp Metastasis. 2020 Dec;37(6):649-656. doi: 10.1007/s10585-020-10058-8. Epub 2020 Oct 24.PMID: 33099724 | 2020 |
Yin S, Qin J, Zhou Q, Zhu C, Li Y, Wu D, Shen Z, Guo Y, Zhou Y, Nashan B. | Sequential metastasis to the liver and pancreas 4 years after gestational trophoblastic neoplasia: a case report. J Int Med Res. 2020 Nov;48(11):300060520966807. doi: 10.1177/0300060520966807.PMID: 33131363 | 2020 |
Hauser IA, Marx S, Sommerer C, Suwelack B, Dragun D, Witzke O, Lehner F, Schiedel C, Porstner M, Thaiss F, Neudörfl C, Falk CS, Nashan B, Sester M. | Effect of everolimus-based drug regimens on CMV-specific T-cell functionality after renal transplantation: 12-month ATHENA subcohort-study results Eur J Immunol. 2020 Dec 11. doi: 10.1002/eji.202048855. Online ahead of print.PMID: 33306229 | 2020 |
Chen W, Tu Q, Zheng H, Wang N, Li X, Huang D, Wu W, Liu L, Nashan B. | An Orthotopic Liver Transplantation Patient Survived Without Hepatic Artery Flow Due to Thrombosis: A Case Report. Transplant Proc. 2021 May;53(4):1295-1299. | 2021 |
Qin J, Zheng H, Li X, Xu Z, Wu W, Huang D, Wang N, Guo Y, Zhu Z, Liu Y, Yao Z, Wang J, Song R, Liu L, Nashan B. | Successful, Combined Long-term Treatment of Cerebral Candidiasis and Aspergillosis in a Liver Transplant Recipient: A Case Report. Transplant Proc. 2021 Oct;53(8):2588-2593. | 2021 |
Yuan X, Huang L, Luo W, Zhao Y, Nashan B, Yu F, Liu Y. | Diagnostic and Prognostic Significances of SOX9 in Thymic Epithelial Tumor. Front Oncol. 2021 Oct 28;11:708735. 10.3389/fonc.2021.708735. eCollection 2021. | 2021 |
Bestard O, Meneghini M, Crespo E, Bemelman F, Koch M, Volk HD, Viklicky O, Giral M, Banas B, Ruiz JC, Melilli E, Hu L, van Duivenvoorden R, Nashan B, Thaiss F, Otto NM, Bold G, Stein M, Sefrin A, Lachmann N, Hruba P, Stranavova L, Brouard S, Braudeau C, Blancho G, Banas M, Irure J, Christakoudi S, Sanchez-Fueyo A, Wood KJ, Reinke P, Grinyó JM. | Preformed T cell alloimmunity and HLA eplet mismatch to guide immunosuppression minimization with tacrolimus monotherapy in kidney transplantation: Results of the CELLIMIN trial. Am J Transplant. 2021 Aug;21(8):2833-2845. doi: 10.1111/ajt.16563. | 2021 |
Burbano De Lara S, Tran DDH, Allister AB, Polenkowski M, Nashan B, Koch M, Tamura T. | C20orf204, a hepatocellular carcinoma-specific protein interacts with nucleolin and promotes cell proliferation. Oncogenesis. 2021 Mar 17;10(3):31. doi: 10.1038/s41389-021-00320-3. | 2021 |
Yuan X, Rasul F, Nashan B, Sun C. | Innate lymphoid cells and cancer: Role in tumor progression and inhibition. Eur J Immunol. 2021 Sep;51(9):2188-2205. doi: 10.1002/eji.202049033. | 2021 |
Nashan B, Schemmer P, Braun F, Schlitt HJ, Pascher A, Klein CG, Neumann UP, Kroeger I, Wimmer P; Hephaistos Study Group. | Early Everolimus-Facilitated Reduced Tacrolimus in Liver Transplantation: Results from the Randomized HEPHAISTOS Trial. Liver Transpl. 2021 Sep 15. doi: 10.1002/lt.26298. | 2021 |
Zhu Z, Liu Y, Wu W, Huang D, Guo Y, Zheng H, Wang N, Xu Z, Li X, Qin J, Liu L, Nashan B. | Liver Transplantation Reverses Hepatic Myelopathy in Hepatitis B-Related Decompensated Liver Cirrhosis: Case Report and Review of the Literature. Transplant Proc Jan-Feb 2022;54(1):158-160. doi: 10.1016/j.transproceed.2021.11.016. | 2022 |
Wu H, He P, Ren Y, Xiao S, Wang W, Liu Z, Li H, Wang Z, Zhang D, Cai J, Zhou X, Jiang D, Fei X, Zhao L, Zhang H, Liu Z, Chen R, Li W, Wang C, Zhang S, Qin J, Nashan B, Sun C. | Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation. Nat Commun 2022 Jan 12;13(1):269. doi: 10.1038/s41467-021-27723-5. | 2022 |
Hou X, Zhu C, Xu M, Chen X, Sun C, Nashan B, Guang S, Feng X. | The SNAPc complex mediates starvation-induced trans-splicing in Caenorhabditis elegans J Genet Genomics. 2022 Oct;49(10):952-964. doi: 10.1016/j.jgg.2022.02.024. Epub 2022 Mar 10.PMID: 35283340 | 2022 |
Moustafa M, Dähling KK, Günther A, Riebandt L, Smit DJ, Riecken K, Schröder C, Zhuang R, Krech T, Kriegs M, Fehse B, Izbicki JR, Fischer L, Nashan B, Li J, Jücker M. | Combined Targeting of AKT and mTOR Inhibits Tumor Formation of EpCAM+ and CD90+ Human Hepatocellular Carcinoma Cells in an Orthotopic Mouse Model Cancers (Basel). 2022 Apr 8;14(8):1882. doi: 10.3390/cancers14081882.PMID: 35454789 | 2022 |
Li M, Zhang T, Zhu J, Li Y, Chen W, Xie Y, Zhang W, Chen R, Wei W, Wang G, Qin J, Zhao W, Wu D, Shen Z, Nashan B, Zhou Y. | Risk factors of perioperative complications and management with enhanced recovery after primary surgery in women with epithelial ovarian carcinoma in a single center Oncol Lett. 2022 May;23(5):155. doi: 10.3892/ol.2022.13274. Epub 2022 Mar 16.PMID: 35836483 | 2022 |
Liu H, Zhao R, Qin R, Sun H, Huang Q, Liu L, Tian Z, Nashan B, Sun C, Sun R. | Panoramic comparison between NK cells in healthy and cancerous liver through single-cell RNA sequencing Cancer Biol Med. 2022 Jul 21;19(9):1334-51. doi: 10.20892/j.issn.2095-3941.2022.0050.PMID: 35856557 | 2022 |
Guo Y, Wang J, Wu W, Huang D, Zheng H, Xu Z, Li X, Wang N, Qin J, Zhu Z, Liu Y, Yao Z, Wang H, Huang Q, Liu L, Nashan B. | Incidence of Ischemia Reperfusion Injury Related Biliary Complications in Liver Transplantation: Effect of Different Types of Donors Transplant Proc. 2022 Sep;54(7):1865-1873. doi: 10.1016/j.transproceed.2022.05.020. Epub 2022 Aug 5.PMID: 35934535 | 2022 |
Wang YS, Wang W, Zhang S, Zhang SY, Shen AZ, Wang W, Song HC, Yao HZ, Song RP, Meng FZ, Li L, Nashan B, Wang JZ, Liu LX. | Clinical efficacy of avatrombopag and recombinant human thrombopoietin in the treatment of chronic liver disease-associated severe thrombocytopenia: A real-world study Front Pharmacol. 2022 Oct 4;13:1009612. doi: 10.3389/fphar.2022.1009612. eCollection 2022.PMID: 36267268 | 2022 |
Hou W, Nsengimana B, Yan C, Nashan B, Han S. | Involvement of endoplasmic reticulum stress in rifampicin-induced liver injury Front Pharmacol. 2022 Oct 20;13:1022809. doi: 10.3389/fphar.2022.1022809. eCollection 2022.PMID: 36339603 | 2022 |
YinS, RongJ, Chen Y, CaoL, LiuY, MoS, LiH, Nan JiangN, ShiH, WangT, ShiY, ZhuY, XiongW, ChenY, XuG, Chen X, Chen X, Yin M, Gong F, Huang W, DongY, Nashan B, Tullius S, Guo Z, Xiaoshun He H | Transplantation of a beating heart: A first in man. Lancet Reg Health West Pac. 2022 Apr 12:23:100449. doi: 10.1016/j.lanwpc.2022.100449. | 2022 |
Nashan B | Porcine cytomegalovirus in xenotransplantation: The new frontier in human transplantation? Health Care Sci. 2022;1–3. DOI: 10.1002/hcs2.7 | 2022 |
Koch M, Zecher D, Lopau K, Weinmann-Menke J, Schulze A, Nashan B, Wenzel U, Banas B, Zeier M, Thaiss F, Sommerer C. | Human Leucocyte Antigen-Matching Can Improve Long Term Outcome of Renal Allografts from Donors Older Than 75 Years Transplant Proc. 2023 Mar;55(2):309-316. doi: 10.1016/j.transproceed.2022.12.014. Epub 2023 Feb 18.PMID: 36801175 | 2023 |
Hou X, Xu M, Zhu C, Gao J, Li M, Chen X, Sun C, Nashan B, Zang J, Zhou Y, Guang S, Feng X. | Systematic characterization of chromodomain proteins reveals an H3K9me1/2 reader regulating aging in C. elegans Nat Commun. 2023 Mar 6;14(1):1254. doi: 10.1038/s41467-023-36898-y.PMID: 36878913 | 2023 |
Zheng H, Zhu Z, Wang N, Qin J, Guo Y, Xu Z, Li X, Qi C, Yuan X, Wu W, Wang J, Liu L, Nashan B. | Entecavir Combined With Short-term Hepatitis B Immunoglobulin in Preventing Hepatitis B Virus Recurrence in Liver Transplant Recipients Transplant Proc. 2023 Mar;55(2):408-412. doi: 10.1016/j.transproceed.2023.02.006. Epub 2023 Mar 10.PMID: 36907782 | 2023 |
Cai W, Wang J, Yin D, Song RP, Liu Y, Xuan Q, Nashan B, Liu L. | Retroperitoneal Laparoscopic Hepatectomy for a Subcapsular Hepatocellular Carcinoma in Segment VI (Video) Ann Surg Oncol. 2023 Sep;30(9):5450-5451. doi: 10.1245/s10434-023-13645-7. Epub 2023 May 20.PMID: 37210450 | 2023 |
Liu Y, Chen X, Luo W, Zhao Y, Nashan B, Huang L, Yuan X. | Identification and validation of Birc5 as a novel activated cell cycle program biomarker associated with infiltration of immunosuppressive myeloid-derived suppressor cells in hepatocellular carcinoma Cancer Med. 2023 Aug;12(15):16370-16385. doi: 10.1002/cam4.6271. Epub 2023 Jun 16.PMID: 37326143 | 2023 |
Fan Y, Nashan B, Wu X, Zhang H, Shi Y. | Prevalence and factors associated with depression and anxiety in living liver donors: A systematic review and meta-analysis J Psychosom Res. 2023 Oct;173:111443. doi: 10.1016/j.jpsychores.2023.111443. Epub 2023 Aug 5.PMID: 37562147 | 2023 |
Guo Z,…..Nashan Björn, …..He X | A randomized-controlled trial of ischemia-free liver transplantation for end-stage liver disease J Hepatol DOI:https://doi.org/10.1016/j.jhep.2023.04.010 | 2023 |
Qin RR, Qin J,Li X, Xu Z, He P, Yuan X, Sun C, Nashan B | Influence of immunosuppressive drugs on natural killer cells in therapeutic drug exposure in liver transplantation HepatoBiliary Surg Nutr 2023;12(6):835-853 | https://dx.doi.org/10.21037/hbsn-22-438 | 2023 |
Nashan B | The German Transplantation Scandal – the Missing References Journal of Liver Transplantation. 12 (2023) 100174. doi.org/10.1016/j.liver.2023.100174 | 2023 |
Arns W, Philippe A, Ditt V, Hauser IA, Thaiss F, Sommerer C, Suwelack B, Dragun D, Hillen J, Schiedel C, Elsässer A, Nashan B | Everolimus plus reduced calcineurin inhibitor prevents de novo anti-HLA antibodies and humoral rejection in kidney transplant recipients: 12-month results from the ATHENA study. Front. Transplant. 2:1264903. doi: 10.3389/frtra.2023.1264903 | 2023 |
Philippe A, Arns W, Ditt V, Hauser IA, Thaiss F, Sommerer C, Suwelack B, Dragun D, Hillen J, Schiedel C, Elsässer A, Nashan B | Impact of everolimus plus calcineurin inhibitor on formation of non-HLA antibodies and graft outcomes in kidney transplant recipients: 12-month results from the ATHENA substudy. Front. Transplant. 2:1273890. doi: 10.3389/frtra.2023.1273890 | 2023 |
Nashan B | Assessment and Evaluation for Patients With Alcohol Use Disorder: The German Allocation Policy. Transplantation. 2023. doi 10.1097/TP.0000000000004884 | 2023 |
Nashan B | Rebuttal to the author’s reply - The German Transplantation Scandal.Journal of Liver Transplantation. 2024 January; 13. doi: 10.1016/j.liver.2023.100197. | 2024 |
Nashan B, Settmacher U, Koch M. | The German Transplant Certification. Hepatobiliary Surg Nutr.2024 Apr 3;13(2):382-386. doi: 10.21037/hbsn-24-36. Epub 2024 Mar 21. PubMed PMID: 38617472; PubMed Central PMCID: PMC11007333. | 2024 |
Krueger MB, Bonifacius A, Dragon AC, Santamorena MM, Nashan B, Taubert R, Kalinke U, Maecker-Kolhoff B, Blasczyk R, Eiz-Vesper B | Transpl Int. 2024;37:12720. doi: 10.3389/ti.2024.12720. eCollection 2024. PubMed PMID: 38655204; PubMed Central PMCID: PMC11035762. | 2024 |
Guo Z, Liu Y, Ling Q, Xu L, Wang T, Zhu J, Lin Y, Lu X, Qu W, Zhang F, Zhu Z, Zhang J, Jia Z, Zeng P, Wang W, Sun Q, Luo Q, Hu Z, Zheng Z, Jia Y, Li J, Zheng Y, Wang M, Wang S, Han Z, Yu S, Li C, Zhang S, Xiong J, Deng F, Liu Y, Chen H, Wang Y, Li L, Liang W, Schlegel A, Nashan B, Liu C, Zheng S, He X | Am J Transplant. 2024 Apr 18;. doi: 10.1016/j.ajt.2024.04.007. PubMed PMID: 38642712. | 2024 |
Yuan X, Qin J, Zheng H, Qi C, Guo Y,Zhu Z, Wu W, Xu Z, Li X, Wang N, Chai X, Xie Y, Tao X, Liu H, Liu W, Liu G, Ye L, Deng K, Li Y, Ji X, Hou C, Yao Z, Huang Q, Song R, Zhang S, Wang J, Liu L,Nashan B | Enhanced Recovery after Liver Transplantation – A Prospective Analysis focusing on Quality Assessment. HepatoBiliary Surg Nutr 2024. doi: 10.21037/hbsn-24-349 | 2024 |
Qin J, Yuan X, Zheng H, Qi C, Guo Y,Zhu Z, Wu W, Xu Z, Li X, Wang N, Chai X, Xie Y, Tao X, Liu H, Liu W, Liu G, Ye L, Deng K, Li Y, Ji X, Hou C, Yao Z, Huang Q, Song R, Zhang S, Wang J, Wang H, Liu L,Nashan B | Establishing a New Liver Transplant Unit in China—First Affiliated Hospital of the University of Science and Technology of China, Hefei, Anhui, People’s Republic of China. Transplantation 2024 Sep 30 DOI: 10.1097/TP.0000000000005219 | 2024 |
Guo Z, Yin M, Sun C, Xu G, Wang T, Jia Z, Zhang Z, Zhu C, Zheng D, Wang L, Huang S, Liu D, Zhang Y, Xie R, Gao N, Zhan L, He S, Zhu Y, Li Y, Nashan B, Andrea S, Xu J, Zhao Q, He X. | Liver protects neuron viability and electrocortical activity in post-cardiac arrest brain injury EMBO Mol Med (2024) | 2024 |
五、联系方式
E-mail: nashan@ustc.edu.cn
电话：18963789207