教授 博导 1998年毕业于中国科学技术大学材料科学与工程系 获理学学士学位 2003年毕业于中国科学技术大学生命科学学院结构生物学专业 获理学博士学位 2003年到2007年在美国科罗拉多健康科学中心全国犹太医学研究中心做博士后研究 现任中国科学技术大学生命科学学院教授 在Cell, Nat. Commun., Proc. Natl. Acad. Sci. USA.，EMBO J., J. Biol. Chem.等杂志上共发表过论文多篇。

主要研究兴趣：

1．染色质修饰的调控与功能

2. 病原微生物感染的分子机理

主要在研课题:

1. 基于同步辐射真空紫外的生物大分子原位成像方法与研究（科技部重点研发项目）

2. 着丝粒蛋白质机器调控细胞命运抉择的分子机制（科技部重点研发项目）

主要代表论文（*：通讯作者）:

1. Hang, T., Chen, W., Wu, M., Zhan, L., Wang, C., Jia, N., Zhang, X* and Zang, J.* (2019) Structural insights into the molecular mechanism underlying Sirt5-catalyzed desuccinylation of histone peptides, Biochem J 476, 211-223.

2. Fang, T., Chen, W., Sheng, Y., Yuan, S., Tang, Q., Li, G., Huang, G., Su, J., Zhang, X.*, Zang, J.* and Liu, Y. * (2019) Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein, Nature commun 10, 186.

3. Wang, C., Zhan, L., Wu, M., Ma, R., Yao, J., Xiong, Y., Pan, Y., Guan, S., Zhang, X.* and Zang, J.* (2018) Spindlin-1 recognizes methylations of K20 and R23 of histone H4 tail, FEBS lett 592, 4098-4110.

4. Tian, T., Wang, C., Wu, M., Zhang, X.* and Zang, J.* (2018) Structural Insights into the Regulation of Staphylococcus aureus Phosphofructokinase by Tetramer-Dimer Conversion, Biochemistry 57, 4252-4262.

5. Tian, T., Li, X., Liu, Y., Wang, C., Liu, X., Bi, G., Zhang, X.*, Yao, X.*, Zhou, Z. H.*, and Zang, J.* (2018) Molecular basis for CENP-N recognition of CENP-A nucleosome on the human kinetochore, Cell Res 28, 374-378.

6. Zhou, X., Zheng, F., Wang, C., Wu, M., Zhang, X., Wang, Q., Yao, X., Fu, C., Zhang, X.* and Zang, J.* (2017) Phosphorylation of CENP-C by Aurora B facilitates kinetochore  attachment error correction in mitosis, Proc Natl Acad Sci USA 114, E10667-E10676.

7. Wang, H., Zhou, X., Wu, M., Wang, C., Zhang, X., Tao, Y., Chen, N., and Zang, J.* (2013) Structure of the JmjC-domain-containing protein JMJD5. Acta Crystallogr D Biol Crystallogr 69, 1911-1920

8. Tao, Y., Wu, M., Zhou, X., Yin, W., Hu, B., de Crombrugghe, B., Sinha, K.M.* and Zang, J.* (2013) Structural Insights into Histone Demethylase NO66 in Interaction with Osteoblast-specific Transcription Factor Osterix and Gene Repression. J Biol Chem, 288, 16430-16437

9. Wu, M., Tao, Y., Liu, X. and Zang, J.* (2013) Structural Basis for Phosphorylated Autoinducer-2 Modulation of the Oligomerization State of the Global Transcription Regulator LsrR from Escherichia coli. J Biol Chem, 288, 15878-15887.

10. Bian, C., Xu, C., Ruan, J., Lee, K. K., Burke, T. L., Tempel, W., Barsyte, D., Li, J., Wu, M., Zhou, B. O., Fleharty, B. E., Paulson, A., Allali-Hassani, A., Zhou, J. Q., Mer, G., Grant, P. A., Workman, J. L.*, Zang, J.* & Min, J.* (2011). Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. EMBO J 30, 2829-42.  

联系方式：

电话：0551－63603435(实验室)，0551－63603433（办公室），

E-mail: zangjy@ustc.edu.cn