博士生导师、主任医师、教授、心内科主任、安徽省首批学术与技术带头人、江淮名医、美国心脏病学会会员(FACC)、美国心血管造影和介入学会会员(SCAI)。
一、学习及工作经历
l1984年--1989年,安徽医科大学医学系,学士学位;
l1989年--1992年,安徽省立医院,内科,住院医生;
l1992年--1995年,华中科技大学同济医学院,心内科,硕士学位;
l1995年--1999年,广州医学院附属第二医院心内科,心内科,主治医师;
l1999年--2000年,安徽省立医院,心内科,历任副主任医师、心内科副主任;
l 2002年,新加坡国家心脏中心,进修学习冠心病介入诊疗技术;
l2004年,由安徽省人事厅公派前往澳大利亚短期专业考察和学习;
l2005年4月--6月,德国巴德贝尔卡中心医院心脏中心,进修冠心病介入新技术;
l2006年破格晋升主任医师;
l2007年晋升为教授;
l2010年,华中科技大学,内科学,博士学位;
l2018年--2019年,中国科学技术大学附属第一医院,心内科副主任、亚专科主任;
l2020年1月--至今,中国科学技术大学附属第一医院,心内科主任;
二、学术成果及影响
致力于冠心病介入诊断与治疗,是国家级首批冠心病介入诊疗培训导师。现任中国胸痛中心联盟副主席、国家心血管病专业质控中心专家委员会冠心病专家工作组专家、安徽省胸痛联盟执行主席、安徽省心血管病质量控制中心副主任、安徽省病理生理学会心血管疾病专业委员会主任委员、中国医疗保健国际交流促进会心血管病分会常委、中国医师协会高血压专业委员会第四届委员会委员、中华医学会心血管病学分会第十一届委员会创新与转化学组委员、中国医师协会心血管内科医师分会第五届委员会冠脉介入学组委员、中国医师协会中西医结合医师分会心脏康复专家委员会委员等职。以第一完成人获安徽省科技进步二等奖1项,三等奖2项,曾获安徽省第十届青年科技奖。迄今主持省部级以上科研课题10余项,发表专业学术论文160余篇,主编出版学术专著2部。
三、在研项目(仅限于主要负责人)
项目名称、来源、经费指标卡号 | 总经费(万元) | 起止日期 |
Periostin介导的巨噬细胞极化对PDGFs/PDGFRs信号通路参与心肌纤维化的调控及分子机制研究(编号81870192),国家自然科学基金面上项目 | 57 | 2018-01至2022-12 |
冠状动脉旋磨术在重度冠状动脉钙化病变治疗中的推广应用研究(编号J2019Y02),合肥市科技局借转补项目 | 100 | 2019-01至2022-12 |
四、主要研究方向(招生专业)及内容
临床医学
1、内科学(心血管)
1) 心肌纤维化;
2) 心脏衰老;
3) 心肌缺血再灌注损伤;
4) 心血管病介入诊断与治疗。
五、代表性论文(近五年)
1、Beilei Wang , Jinsheng Hua, Renchuan You, Kun Yan, Likun Ma*. Electrochemically deposition of catechol-chitosan hydrogel coating on coronary stent with robust copper ions immobilization capability and improved interfacial biological activity. Int J Biol Macromol, 2021 Mar 26;S0141-8130(21)00702-9. doi: 10.1016/j.ijbiomac.2021.03.158.
2、Zheng Gong, Qing Ye, Jia-Wei Wu, Jun-Ling Zhou, Xiang-Yong Kong, Li-Kun Ma*. UCHL1 inhibition attenuates cardiac fibrosis via modulation of nuclear factor-<kappa>B signaling in fibroblasts. Eur J Pharmacol. 2021 Mar 18:174045. doi: 10.1016/j.ejphar.2021.174045.
3、Hongwu Chen, Xiaofan Yu, Likun Ma*. Risk Factors of Contrast Induced Nephropathy in Patients with STEMI and Pump Failure undergoing either Primary Percutaneous Coronary Intervention or Elective Percutaneous Coronary Intervention: Findings from the Improving Care for Cardiovascular Disease Project in China. Experimental and Therapeutic Medicine.2021;21(2): doi: 10.3892/etm.2020.9572.
4、Xudong Zhu, Weiyan Shen, Zhu Liu, Shihao Sheng, Wei Xiong, Ruikun He, Xuguang Zhang, Likun Ma*, Zhenyu Ju. Effect of Metformin on Cardiac Metabolism and Longevity in Aged Female Mice. Front Cell Dev Biol, 2021; 8: 1739.
5、Dan Li, Wen Jin, Li Sun, Jiawei Wu, Hao Hu and Likun Ma*. Circ_0065149 Alleviates Oxidized Low-Density Lipoprotein-InducedApoptosis and Inflammation in Atherosclerosis by Targeting miR-330-5p. Front Genet, 2021; 12
6、Jia-Wei Wu, Hao Hu, Dan Li, Li-Kun Ma*. Hypoxia-inducible factor 2-alpha-dependent induction of IL-6 protects the heart from ischemia/reperfusion injury. AGING 2020;13(3):3443-3458.
7、Qing Ye, Jie Zhang, Likun Ma*. Predictors of all-cause 1-year mortality in myocardial infarction patients. Medicine (Baltimore).2020 Jul 17 ;99(29) :e21288.
8、Hongwu Chen, Xiaofan Yu, Xiangyong Kong, Longwei Li, Jiawei Wu, Likun Ma*. Predictive value of ACEF score for clinical prognosis of elderly patients with ST-segment elevation myocardial infarction after percutaneous coronary intervention. Annals of Palliative Medicine. 2020 Oct 20;apm-20-591.
9、Hao Hu, Jiawei Wu, Xiaofan Yu, Junling Zhou, Likun Ma*. Long noncoding RNA MALAT1 enhances the apoptosis of cardiomyocytes through autophagy modulation. Biochem Cell Biol. 2020;98(2):130-136.
10、Hao Hu, Jiawei Wu, Cheng Chao, Likun Ma*. Exosomes derived from regulatory T cells ameliorate acute myocardial infarction by promoting macrophage M2 polarization. IUBMB Life 2020;72(11):2409-2419.
11、 Junling Zhou, Longwei Li, Hao Hu, Jiawei Wu, Hongwu Chen, Kefu Feng, Likun Ma*. Circ-HIPK2 Accelerates Cell Apoptosis and Autophagy in Myocardial Oxidative Injury by Sponging miR-485-5p and Targeting ATG101. J Cardiovasc Pharmacol. 2020; 76(4): 427-436.
12、 Dongbiao YU, Likun MA*, Junling ZHOU, Longwei LI, Wu YAN and Xiaofen YU. Influence of CYP2C19 genotype on antiplatelet treatment outcomes after percutaneous coronary intervention in patients with coronary heart disease. EXPERIMENTAL AND THERAPEUTIC MEDICINE 19: 3411-3418, 2020
13、Jinsheng Hua, Haining You, Xiufang Li, Renchuan You, Likun Ma*. Cu(II) ion loading in silk fibroin scaffolds with silk I structure. International Journal of Biological Macromolecules 2020,158:275–281.
14、WEI CAO, LIKUN MA*. Curative effect of β-blocker on various ejection fractions of patients with atrial fibrillation. Exp Ther Med.2019 Aug;18(2):1149-1154.
15、Jiawei Wu, Hao Hu, Dan Li, Likun Ma*. In-hospital outcomes of delayed stenting in hemodynamically stable patients with ST-segment elevation myocardial infarction: the CCC (Care for Cardiovascular Disease in China) project. Cardiovasc Diagn Ther 2019; 9:462-471.
16、Zhou Junling, Li Longwei, Hao Hu, Jiawei Wu, Hongwu Chen, Kefu Feng, Likun Ma*. Clinical efficacy of clopidogrel combined with aspirin for acute myocardial infarction and its effects on HS-CRP, NT-proBNP, CTNI, ET and MMP-9 levels. Acta Medica Mediterranea 2019, 35: 2345-2349.
17、Hao Hu, Jiawei Wu, Xiaofan Yu, Hua Yu, Likun Ma*. Long non-coding RNA MALAT1 enhances the apoptosis of cardiomyocytes through autophagy inhibition by regulating TSC2-mTOR signaling. Biol Res 2019;52:58.
18、Hu hao, Wu jiawei, Li dan, Zhou junling, Yu hua, Ma Likun*. Knockdown of lncRNA MALAT1 attenuates acute myocardial infarction through miR-320-Pten axis. Biomed Pharmacother. 2018 Oct;106:738-746
19、Han zhang Wang, LiKun Ma*, Lei Wang, Long wei Li, Jia wei Wu. PDGF-CC induced rat myocardial fibrosis is mediated by ERK1/2 signaling pathway and potential mechanism[J]. International Journal of Clinical and Experimental Medicine. 2017;10(12):16344-16351.
20、Lei Wang, LiKun Ma*, Hai Fan, Zhe Yang, LongWei Li, HanZhang Wang. MicroRNA-9 regulates cardiac fibrosis by targeting PDGFR-β in rats. J Physiol Biochem, 2016; 72:213–223.
六、联系方式
E-mail: lkma@ustc.edu.cn, lkma119@163.com
电话:18756967633 / 0551-62284055