博士生导师，特任研究员。

一、学习及工作经历

l1997年--2001年，浙江大学生命科学学院，生物化学专业，理学学士；

l2001年--2009年，中国科学院上海生物化学与细胞生物学研究所，生物化学与分子生物学专业，理学博士；

l2009年--2011年，美国俄亥俄州立大学医学中心，博士后；

l2011年--2018年，美国克利夫兰医学中心，博士后；

l2018年--至今，中国科技大学，生命科学学院与附属第一医院，特任研究员；

二、学术成果及影响

主要从事胶质瘤干细胞(glioma stem cell, GSC) 和肿瘤微环境的相关研究。研究领域包括肿瘤免疫、肿瘤血管生成、肿瘤干细胞特异性调节分子等。在肿瘤免疫微环境研究方向，发现胶质瘤干细胞可以通过分泌POSTN蛋白来促进巨噬细胞对肿瘤的浸润，而巨噬细胞进一步支持肿瘤恶性发展，二者形成一个恶性正反馈调节回路促进肿瘤发展。在肿瘤血管系统研究方向，发现肿瘤血管周细胞来源于胶质瘤干细胞，而周细胞覆盖于血管内皮细胞，决定了血癌屏障以及药物传递效率，是化学治疗的关键靶点。在Cell, Cell Stem Cell, Nature Cell Biology, Science Translational Medicine等杂志发表论文20余篇，包括2篇ESI高引用论文，总引用次数超过3000次。

 三、在研项目(仅限于主要负责人)

四、主要研究方向（招生专业）及内容

生物学

1、细胞生物学
1）胶质瘤干细胞与肿瘤相关的巨噬细胞相互作用的分子机制；
2）胶质瘤肿瘤血管周细胞的分化与维持的分子调控机制；
3）胶质瘤干细胞干性维持相关的信号通路；

五、代表性论文（近五年）

1. Aili Zhang, Weiwei Tao, Kui Zhai, Xiaoguang Fang, Zhi Huang, Jennifer S Yu, Andrew E Sloan, Jeremy N Rich, Wenchao Zhou*, Shideng Bao*. Protein sumoylation with SUMO1 promoted by Pin1 in glioma stem cells augments glioblastoma malignancy. Neuro Oncol. 2020 Dec 18;22(12):1809-1821.

2. Yue-E Wang, Jing-Jing Chen, Wei Wang, An-Li Zhang, Wenchao Zhou*, Hai-Bo Wu*. A case of desmoplastic myxoid tumor, SMARCB1 mutant, in the pineal region. Neuropathology. 2020 Sep 9. doi: 10.1111/neup.12695.

3. Jennifer Liang#, Wenchao Zhou#, Nneha Sakre, Jennifer DeVecchio, Sylvain Ferrandon, Angela H. Ting, Shideng Bao, Ian Bissett, James Church & Matthew F. Kalady Epigenetically regulated miR-1247 functions as a novel tumour suppressor via MYCBP2 in methylator colon cancers. Br J Cancer. 2018 Nov;119(10):1267-1277.

4. Wenchao Zhou, Cong Chen, Yu Shi, Qiulian Wu, Ryan C. Gimple, Xiaoguang Fang, Zhi Huang, Kui Zhai, Susan Q. Ke, Yi-Fang Ping, Hua Feng, Jeremy N. Rich, Jennifer S. Yu, Shideng Bao, and Xiu-Wu Bian. Targeting glioma stem cell-derived pericytes disrupts the blood-tumor barrier and improves chemotherapeutic efficacy. Cell Stem Cell. 2017 Nov;21 (5): 591-603.

5. Shuya Li, Min Li, Shaohu Huo, Qin Wang, Jing Chen, Shenggang Ding, Zhutian Zeng, Wenchao Zhou, Yucai Wang*, Jun Wang*. Voluntary-Opsonization-Enabled Precision Nanomedicines for Inflammation Treatment. Adv Mater. 2021 Jan;33(3):e2006160. doi: 10.1002/adma.202006160.

6. Weiwei Tao, Aili Zhang, Kui Zhai, Zhi Huang, Haidong Huang, Wenchao Zhou, Qian Huang, Xiaoguang Fang, Briana C Prager, Xiuxing Wang, Qiulian Wu, Andrew E Sloan, Manmeet S Ahluwalia, Justin D Lathia, Jennifer S Yu, Jeremy N Rich, Shideng Bao. SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells. EMBO Mol Med. 2020 Dec 7;12(12):e12291. doi: 10.15252/emmm.202012291.

7. Weiwei Tao, Chengwei Chu, Wenchao Zhou, Zhi Huang, Kui Zhai, Xiaoguang Fang, Qian Huang, Aili Zhang, Xiuxing Wang, Xingjiang Yu, Haidong Huang, Qiulian Wu, Andrew E Sloan, S Yu Jennifer, Xiaoxia Li, George R Stark, Jeremy N Rich, Shideng Bao. Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma. Nat Commun. 2020 Jun 15;11(1):3015. doi: 10.1038/s41467-020-16827-z.

8. Shuya Li, Qin Wang, Yanqiong Shen, Muhammad Hassan, Jizhou Shen, Wei Jiang, Yitan Su, Jing Chen, Li Bai, Wenchao Zhou, Yucai Wang. Nano Lett. 2020 Jan 8;20(1):242-251. doi: 10.1021/acs.nanolett.9b03753.

9. Zhen Dong, Guoxin Zhang, Meng Qu, Ryan C Gimple, Qiulian Wu, Zhixin Qiu, Briana C Prager, Xiuxing Wang, Leo JY Kim, Andrew R Morton, Deobrat Dixit, Wenchao Zhou, Haidong Huang, Bin Li, Zhe Zhu, Shideng Bao, Stephen C Mack, Lukas Chavez, Steve A Kay, Jeremy N Rich. Cancer Discov. 2019 Nov;9(11):1556-1573. doi: 10.1158/2159-8290.CD-19-0215.

10. Xiuxing Wang, Kailin Yang, Qiulian Wu, Leo JY Kim, Andrew R Morton, Ryan C Gimple, Briana C Prager, Yu Shi, Wenchao Zhou, Shruti Bhargava, Zhe Zhu, Li Jiang, Weiwei Tao, Zhixin Qiu, Linjie Zhao, Guoxing Zhang, Xiqing Li, Sameer Agnihotri, Paul S Mischel, Stephen C Mack, Shideng Bao, Jeremy N Rich. Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells. Sci Transl Med. 2019 Aug 7;11(504):eaau4972. doi: 10.1126/scitranslmed.aau4972.

11. Stephen C Mack, Irtisha Singh, Xiuxing Wang, Rachel Hirsch, Quilian Wu, Rosie Villagomez, Jean A Bernatchez, Zhe Zhu, Ryan C Gimple, Leo JY Kim, Andrew Morton, Sisi Lai, Zhixin Qiu, Briana C Prager, Kelsey C Bertrand, Clarence Mah, Wenchao Zhou, Christine Lee, Gene H Barnett, Michael A Vogelbaum, Andrew E Sloan, Lukas Chavez, Shideng Bao, Peter C Scacheri, Jair L Siqueira-Neto, Charles Y Lin, Jeremy N Rich. Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma. J Exp Med. 2019 May 6;216(5):1071-1090. doi: 10.1084/jem.20190196.

12. Cong Chen, Zhi-cheng He, Yu Shi, Wenchao Zhou, Xia Zhang, Hua-liang Xiao, Hai-bo Wu, Xiao-hong Yao, Wan-chun Luo, You-hong Cui, Shideng Bao, Hsiang-fu Kung, Xiu-wu Bian, Yi-fang Ping. Microvascular fractal dimension predicts prognosis and response to chemotherapy in glioblastoma: an automatic image analysis study. Lab Invest. 2018 Jul;98(7):924-934. doi: 10.1038/s41374-018-0055-2.

13. Yu Shi, Olga A. Guryanova, Wenchao Zhou, Chong Liu, Zhi Huang, Xiaoguang Fang, Xiuxing Wang, Cong Chen, Qiulian Wu, Zhicheng He, Wei Wang, Wei Zhang, Tao Jiang, Qing Liu, Yaping Chen, Wenying Wang, Jingjing Wu, Leo Kim, Ryan C. Gimple, Hua Feng, Hsiang-Fu Kung, Jennifer S. Yu, Jeremy N. Rich, Yi-Fang Ping#, Xiu-Wu Bian,# and Shideng Bao#. Ibrutinib inactivates BMX-STAT3 in glioma stem cells to impair malignant growth and radioresistance. Sci Transl Med. 2018 May 30;10(443). pii: eaah6816. doi: 10.1126/scitranslmed.aah6816.

14. Xiuxing Wang, Briana C Prager, Qiulian Wu, Leo JY Kim, Ryan C Gimple, Yu Shi, Kailin Yang, Andrew R Morton, Wenchao Zhou, Zhe Zhu, Elisabeth Anne Adanma Obara, Tyler E Miller, Anne Song, Sisi Lai, Christopher G Hubert, Xun Jin, Zhi Huang, Xiaoguang Fang, Deobrat Dixit, Weiwei Tao, Kui Zhai, Cong Chen, Zhen Dong, Guoxin Zhang, Stephen M Dombrowski, Petra Hamerlik, Stephen C Mack, Shideng Bao, Jeremy N Rich. Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression. Cell Stem Cell. 2018 Apr 5;22(4):514-528.

15. Xiuxing Wang, Zhi Huang, Qiulian Wu, Briana C Prager, Stephen C Mack, Kailin Yang, Leo JY Kim, Ryan C Gimple, Yu Shi, Sisi Lai, Qi Xie, Tyler E Miller, Christopher G Hubert, Anne Song, Zhen Dong, Wenchao Zhou, Xiaoguang Fang, Zhe Zhu, Vaidehi Mahadev, Shideng Bao, Jeremy N Rich. MYC regulated mevalonate metabolism maintains brain tumor-initiating cells. Cancer Res. 2017 Sep 15;77(18):4947-4960.

16.  Jianghong Man*, Xingjiang Yu*, Haidong Huang, Wenchao Zhou, Chaomei Xiang, Haohao Huang, Lucio Miele, Zhenggang Liu, Gurkan Bebek, Shideng Bao, Jennifer S. Yu. Hypoxic induction of Vasorin regulates Notch1 turnover to maintain glioma stem-like cells. Cell Stem Cell. 2018 Jan 4;22(1):104-118.

17.Xiuxing Wang, Kailin Yang, Qi Xie, Qiulian Wu, Stephen C. Mack, Yu Shi, Leo Kim, Briana C. Prager, William A. Flavahan, Xiaojing Liu, Meromit Singer, Christopher G. Hubert, Tyler E. Miller, Wenchao Zhou, Zhi Huang, Xiaoguang Fang, Aviv Regev, Mario L. Suva, Tae Hyun Hwang, Jason W. Locasale, Shideng Bao & Jeremy N. Rich. Purine synthesis promotes brain tumor initiating cell maintenance in glioma. Nat Neurosci. 2017 Mar 27. doi: 10.1038/nn.4537.

18.  Xiaoguang Fang, Wenchao Zhou, Qiulian Wu, Zhi Huang, Yu Shi, Kailin Yang, Cong Chen, Qi Xie, Stephen C Mack, Xiuxing Wang, Angel M Carcaboso, Andrew E Sloan, Gaoliang Ouyang, Roger E McLendon, Xiu-wu Bian, Jeremy N Rich, and Shideng Bao. Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination. J Exp Med. 2017 Jan;214(1):245-267.

19.  Yu Shi, Yi-Fang Ping, Wenchao Zhou, Zhi-Cheng He, Cong Chen, Bai-Shi-Jiao Bian, Lin Zhang, Lu Chen, Xun Lan, Xianchao Zhang, Kai Zhou, Qing Liu, Hua Long, Tiwei Fu, Xiao-Ning Zhang, Mianfu Cao, Zhi Huang, Xiaoguang Fang, Xiuxing Wang, Hua Feng, Xiao-Hong Yao, Shi-Cang Yu, You-Hong Cui, Xia Zhang, Jeremy N. Rich, Shideng Bao & Xiu-Wu Bian. Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signaling in glioblastoma stem cells for tumour growth. Nat Commun. 2017 Jun 1; 8: 15080.

20.  Yu Shi, Wenchao Zhou, Lin Cheng, Cong Chen, Zhi Huang, Xiaoguang Fang, Qiulian Wu, Zhicheng He, Senlin Xu, Justin D Lathia, Yifang Ping, Jeremy N Rich, Xiu-Wu Bian, and Shideng Bao. Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells. Cell Death Differ. 2017 Jan;24(1):167-180.

21.  Qi Xie, Qiulian Wu, Leo Kim, Tyler E. Miller, Brian B. Liau, Stephen C. Mack, Kailin Yang, Daniel C. Factor, Xiaoguang Fang, Zhi Huang, Wenchao Zhou, Kareem Alazem, Xiuxing Wang, Bradley E. Bernstein, Shideng Bao, and Jeremy N. Rich. RBPJ maintains brain tumor–initiating cells through CDK9-mediated transcriptional elongation. J Clin Invest. 2016 Jul 1;126(7):2757-72.

六、联系方式

邮箱：wzaz@ustc.edu.cn