主要研究兴趣:
1. 细胞有丝分裂的化学生物学研究
2. 细胞器互作与类器官可塑性调控研究
3. 无膜细胞器与细胞命运抉择机制研究
博士,特任教授,细胞动力学教育部重点实验室副主任。2008年毕业于安徽大学化学与化工学院,获理学学士。2008年至2014年,就读于中国科学技术大学生命科学学院,获得理学博士学位。2014年至2016年于合肥微尺度物质科学国家实验室(筹)从事博士后研究。2017年至2019年任中国科学技术大学生命科学学院副教授,赴HHMI Janelia Farm Research Campus与Atlanta Clinical Translational Science Institute进行合作研究。2019年至今任中国科学技术大学生命科学学院特任教授。主要研究成果发表于Nature Chemical Biology、Cell Research、PNAS、Cell Rep、EMBO Rep、J Biol Chem、J Mol Cell Biol等国际高水平杂志。2019年获得国家自然科学基金委“优秀青年科学基金”项目的资助。2021年荣获国际期刊J Mol Cell Biol “Best Editor Award”。中国科协“中学生英才计划”生物学科导师团队成员(2016年-至今),任中国细胞生物学会对外交流工作委员会委员(2020-2023);中国生物物理学会生物大分子相分离与相变分会委员(2021年2025)。
近期代表性学术论文(# 第一作者;* 通讯作者):
1. Liu S, Yuan X, Gui P, Liu R, Durojaye O, Hill DL, Fu C, Yao X*, Dou Z*, Liu X*. Mad2 promotes Cyclin B2 recruitment to the kinetochore for guiding accurate mitotic checkpoint. EMBO Rep. 23(6):e54171. (2022)
2. Song X#, Yang F#, Liu X#, Xia P#, Yin W, Wang Z, Wang Y, Yuan X, Dou Z, Jiang K, Ma M, Hu B, Zhang R, Xu C, Zhang Z, Ruan K, Tian R, Li L, Liu T, Hill DL, Zang J*, Liu X*, Li J*, Cheng J*, Yao X*. Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis. Nat Chem Biol. 17(12):1314-1323. (2021) (Highlighted by Nature Chemical Biology)
3. Xu L#, Ali M#, Duan W#, Yuan X*, Garba F, Mullen M, Sun B, Poser I, Duan H, Lu J, Tian R, Ge Y, Chu L, Pan W, Wang D, Hyman A, Green H, Li L, Dou Z*, Liu D*, Liu X*, Yao X*. Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation. Cell Rep. 36(2):109343. (2021)
4. Tang R#, Jiang Z#, Chen F#, Yu W, Fan K, Tan J, Zhang Z, Liu X*, Li P, Yuan K*. The Kinase Activity of Drosophila BubR1 Is Required for Insulin Signaling-Dependent Stem Cell Maintenance. Cell Rep. 31(12):107794.(2020)
5. Liu X, Liu X, Wang H, Dou Z, Ruan K, Hill DL, Li L, Shi Y, Yao X*. Phase separation drives decision making in cell division. J Biol Chem. 295(39):13419-13431. (2020) Review. (Recommended by F1000)
6. Huang Y#, Lin L#, Liu X#, Ye S#, Yao PY, Wang W, Yang F, Gao X, Li J, Zhang Y, Zhang J, Yang Z, Liu X, Yang Z, Zang J, Teng M, Wang Z, Ruan K, Ding X, Li L, Cleveland DW, Zhang R*, Yao X*. BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules. Cell Res. 29(7):562-578. (2019) (Highlighted by Cell Research)
7. Akram S#, Yang F#, Li J#, Adams G, Liu Y, Zhuang X, Chu L, Liu X, Emmett N, Thompson W, Mullen M, Muthusamy S, Wang W, Mo F*, Liu X*. LRIF1 interacts with HP1α to coordinate accurate chromosome segregation during mitosis. J Mol Cell Biol. 10(6):527-538. (2018)
8. Yuan X, Yao PY, Jiang J, Zhang Y, Su Z, Yao W, Wang X, Gui P, Mullen M, Henry C, Ward T, Wang W, Brako L, Tian R, Zhao X, Wang F, Cao X, Wang D, Liu X*, Ding X*, Yao X*. MST4 phosphorylates ACAP4 to orchestrate apical membrane remodeling during gastric acid secretion. J Biol Chem. 292(39):16174-16187. (2017)
9. Mo F#, Zhuang X#, Liu X*, Yao PY, Qin B, Su Z, Zang J, Wang Z, Zhang J, Dou Z, Tian C, Teng M, Niu L, Hill DL, Fang G, Ding X, Fu C, Yao X*. Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation. Nat Chem Biol. 12(4):226-32. (2016) (Highlighted by Nature Chemical Biology)
10. Zhou J#, Liu H#, Zhou S, He P, Liu X*. Adaptor protein APPL1 interacts with EGFR to orchestrate EGF-stimulated signaling. Sci Bull. 61(19): 1504-1512. (2016)
11. Dou Z#, Liu X#, Wang W, Zhu T, Wang X, Xu L, Abrieu A, Fu C, Hill DL, Yao X*. Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachment. Proc Natl Acad Sci U S A. 112(33):E4546-55. (2015)
12. Liu X#, Song Z#, Huo Y, Zhang J, Zhu T, Wang J, Zhao X, Aikhionbare F, Zhang J, Duan H, Wu J, Dou Z, Shi Y and Yao X*. Chromatin protein HP1 interacts with the mitotic regulator borealin protein and specifies the centromere localization of the chromosomal passenger complex. J Biol Chem. 289(30):20638-49. (2014)
联系方式:
电话:0551-63607141;E-mail:xing1017@ustc.edu.cn
主页:http://lcd.ustc.edu.cn/professor6.html
ResearcherID: http://www.researcherid.com/rid/H-2989-2018