中国科学技术大学生命科学与医学部特任研究员、博士生导师、课题组长。1998年至2002年本科就读于浙江大学环境工程系； 2003年至2010年硕博连读于中国科学院上海生命科学研究院植物生理生态研究所, 从事植物发育生物学研究； 2010年至2017年于英国约翰英纳斯中心（John Innes Centre，JIC）任博士后、 2018年至2019年于剑桥大学塞恩斯伯里实验室（The Sainsbury Laboratory, Cambridge University）任研究助理，从事植物微生物共生相关研究。2020年加入中国科学技术大学，组建植物-微生物共生实验室。获中国科学院 择优支持、主持国家自然科学基金面上项目2项（2022-2025，2025-2028）、获国家自然科学基金创新研究群体项目“植物环境感受和可塑性发育”（2024-2028，参与）和中国科学院稳定支持基础研究领域青年团队计划项目“豆科植物-根瘤菌共生固氮的机理和改造”（2021-2025，参与）等资助。现任中国植物学会植物生理及分子生物学专业委员会委员。
实验室研究方向
植物-微生物共生/豆科植物-根瘤菌共生固氮
实验室研究背景
氮是生命体的基本元素，也是地球上生命活动所必须的营养成分。农业是人类的衣食之源，尽管空气中氮含量高达78%, 但并不能被农作物直接吸收利用；而豆科植物和作物如大豆、苜蓿、花生、豌豆等可以与土壤中的根瘤菌形成共生、通过根瘤菌生物固氮的过程将氮气转化为植物可以利用的氮源。这种高效的天然固氮系统既节约能源、又保护环境，因此被认为是发展可持续性绿色农业的重要氮肥来源。而研究和解析豆科植物-根瘤菌共生固氮的机制，是将其高效应用于现代绿色农业的关键基础。
实验室主要从事豆科植物-根瘤菌共生固氮机制的研究。在豆科植物调控根瘤菌侵染的研究中，发现豆科植物中首个调控根瘤菌侵染线极性生长的豆科植物蛋白复合体(侵染复合体，infectosome)；建立豆科模式植物蒺藜苜蓿中首个根毛特异的根瘤菌侵染转录组 (root hair infectome)；解析豆科植物中首个根瘤菌侵染的基因调控网络并揭示固氮共生进化中重要转录因子的核心调控作用等。主要研究成果发表于Nature Communications、The Plant Cell、The EMBO Journal、New Phytologist和Plant Physiology等期刊，其中infectome系列研究成果为ESI高被引论文、侵染复合体infectosome相关发现被认为“发展了研究和理解根瘤菌侵染线发育机制的新方向”。实验室主要以蒺藜苜蓿（Medicago truncatula）等豆科为模式植物，在豆科植物与根瘤菌及其他共生菌互作体系中，综合利用遗传学、细胞生物学、分子生物学、生物化学、生物信息学结合多组学等手段，致力于揭示植物-微生物共生中最基本的细胞和分子机理、及进化机制。
实验室目前研究内容
1. 豆科植物-根瘤菌共生固氮的分子机理
2. 豆科宿主适应根瘤菌侵染的亚细胞系统重塑
3. 豆科侵染复合体调控侵染线发育的细胞和分子机制
4. 根瘤菌侵染及丛枝菌根真菌侵染机制的进化
发表论文（#共同第一作者， *通讯作者）
1. Jin-Li Deng, Li Zhao, Hong Wei, Han-Xiao Ye, Li Yang, Linfeng Sun, Zhong Zhao, Jeremy D Murray, Cheng-Wu Liu*. A deeply conserved amino acid required for VAPYRIN localization and function during legume-rhizobial symbiosis. New Phytologist243(1):14-22 (2024).
2. Wenjuan Wu, Yuxin Zhuang, Dasong Chen, Yiting Ruan, Fuyu Li, Kirsty Jackson, Cheng-Wu Liu, Alison East, Jiangqi Wen, Evangelos Tatsis, Philip S. Poole, Ping Xu*, Jeremy D. Murray*. Methylated chalcones are required for rhizobial nod gene induction in the Medicago truncatula rhizosphere. New Phytologist242(5):2195-2206 (2024).
3. Jin-Peng Gao, Wenjie Liang, Cheng-Wu Liu, Fang Xie, Jeremy D Murray*. Unraveling the rhizobial infection thread. Journal of Experimental Botany 75(8):2235-2245 (2024).
4. Zhijian Liu, Jun Yang, Yanping Long, Chi Zhang, Dapeng Wang, Xiaowei Zhang, Wentao Dong, Li Zhao, Chengwu Liu, Jixian Zhai*, Ertao Wang*. Single-nucleus transcriptomes reveal spatiotemporal symbiotic perception and early response in Medicago. Nature Plants 9(10):1734-1748 (2023).
5. Yang Jun, Liu Chengwu*, Li Xia*, Tian Changfu*, Xie Fang*, Cao Yangrong*, Wang Ertao*. Advances in the legume–rhizobia symbiosis. Plant Physiology Journal 59 (8): 1407–1435 1407 (2023).
6. Beatrice Lace*, Chao Su, Daniel Invernot Perez, Marta Rodriguez-Franco, Tatiana Vernié, Morgane Batzenschlager, Sabrina Egli, Cheng-Wu Liu, Thomas Ott*. RPG acts as a central determinant for infectosome formation and cellular polarization during intracellular rhizobial infections. eLife 12: e80741 (2023).
7. Wang J, Pislariu CI, Liu C-W, Tsyganov VE and DasGupta M Editorial: Molecular and cellular mechanisms of the legume-rhizobia symbiosis, volume II. Frontiers in Plant Science 14:1208904 (2023).
8. Jin-Peng Gao, Suyu Jiang, Yangyang Su, Ping Xu, Junjie Wang, Wenjie Liang , Cheng-Wu Liu, Jeremy D Murray*. Intracellular infection by symbiotic bacteria requires the mitotic kinase AURORA1. PNAS 119(43):e2202606119 (2022).
9. Qiying Xiao#, Yi Chen#, Cheng-Wu Liu#, Fran Robson, Sonali Roy, Xiaofei Cheng, Jiangqi Wen, Kirankumar Mysore, Anthony J. Miller*, Jeremy D. Murray*. MtNPF6.5 mediates chloride uptake and nitrate preference in Medicago roots. The EMBO Journal 40(21):e106847 (2021).
10. Cheng-Wu Liu* and Shutang Tan*. Nitrate signaling: A translator between nitrate perception and calcium signalling. Molecular Plant 14(5):718-719 (2021).
11. Sonali Roy, Andrew Breakspear, Donna Cousins, Ivone Torres-Jerez, Kirsty Jean Jackson, Anil Kumar, YangYang Su, Nick Krom, Cheng-Wu Liu, Michael Udvardi, Ping Xu*, Jeremy Dale Murray*. Three common symbiotic ABC-B transporters in Medicago truncatula are regulated by a NIN-independent branch of the symbiosis signalling pathway. Mol Plant Microbe Interact. 34(8):939-951 (2021).
12. Chengwu Liu, Zhong Zhao*. The Legume SHR-SCR Module Predetermines Nodule Founder Cell Identity. Chinese Bulletin of Botany 55(6): 661-665 (2020).
13. Anil Kumar#, Donna R. Cousins #, Cheng-Wu Liu, Ping Xu*, Jeremy D. Murray*. Nodule Inception Is Not Required for Arbuscular Mycorrhizal Colonization of Medicago truncatula.Plants-Basel 9(1): 71 (2020).
14. Cheng-Wu Liu, Andrew Breakspear, Nicola Stacey, Kim Findlay, Jin Nakashima, Karunakaran Ramakrishnan, Miaoxia Liu, Fang Xie, Gabriella Endre, Fernanda de Carvlho-Niebel, Giles E. D. Oldroyd, Michael K. Udvardi, Joëlle Fournier*, Jeremy D. Murray*. A protein complex required for polar growth of rhizobial infection threads. Nature Communications10(1):2848(2019).
15. Cheng-Wu Liu#, Andrew Breakspear#, Dian Guan, Marion R. Cerri, Kirsty Jackson, Suyu Jiang, Fran Robson, Guru V. Radhakrishnan, Sonali Roy, Caitlin Bone, Nicola Stacey, Christian Rogers, Martin Trick, Andreas Niebel, Giles E. D. Oldroyd, Fernanda de Carvalho-Niebel, Jeremy D. Murray*. NIN acts a network hub controlling a growth module required for rhizobial infection. Plant Physiology179(4):1704-1722 (2019).
16. Sonali Roy, Fran Robson, Jodi Lilley, Cheng-WuLiu, Xiaofei Cheng, Jiangqi Wen, Simon Walker, Jongho Sun, Donna Cousins, Caitlin Bone, Malcolm J. Bennett, J. Allan Downie, Ranjan Swarup, Giles Oldroyd, Jeremy D. Murray*. MtLAX2, a functional homologue of the Arabidopsis auxin influx transporter AUX1, is required for nodule organogenesis. Plant Physiology 174: 326-338 (2017).
17. James K. Hane#, Yao Ming#, Lars G. Kamphuis#, Matthew N. Nelson, Gagan Garg, Craig A. Atkins, Philipp E. Bayer, Armando Bravo, Scott Bringans, Steven Cannon, David Edwards, Rhonda Foley, Ling-ling Gao, Maria J. Harrison, Wei Huang, Bhavna Hurgobin, Sean Li, Cheng-WuLiu, Annette McGrath, Grant Morahan, Jeremy Murray, James Weller, Jianbo Jian, Karam B. Singh*. A comprehensive draft genome sequence for lupin (Lupinus angustifolius), an emerging health food: insights into plant–microbe interactions and legume evolution. Plant Biotechnology Journal15 (3): 318–30 (2017).
18. Cheng-Wu Liu, Jeremy D. Murray*. The role of flavonoids in nodulation host-range specificity: an update. Plants-Basel 5(3):33 (2016).
19. Jeremy D. Murray*, Cheng-Wu Liu, Yi Chen, Anthony J. Miller*. Nitrogen sensing in legumes. Journal of Experimental Botany68(8):1919-1926 (2016).
20. Senjuti Sinharoy, Cheng-WuLiu, Andrew Breakspear, Dian Guan, Sarah Shailes, Jin Nakashima, Shulan Zhang, Jiangqi Wen, Ivone Torres-Jerez, Giles Oldroyd, Jeremy D. Murray, Michael K. Udvardi*. A Medicago truncatula Cystathionine Beta Synthase like domain-containing protein is required for rhizobial infection and symbiotic nitrogen fixation. Plant Physiology 170:2204-17 (2016).
21. Cheng-Wu Liu, Andrew Breakspear, Sonali Roy, Jeremy D. Murray*. Cytokinin responses counterpoint auxin signaling during rhizobial infection. Plant Signaling & Behavior 10: e1019982 (2015).
22. Dasong Chen, Cheng-WuLiu, Sonali Roy, Donna Cousins, Nicola Stacey, Jeremy D. Murray*. Identification of a core set of rhizobial infection genes using data from single cell-types. Frontiers in Plant Science 6:575 (2015).
23. Andrew Breakspear, ChengwuLiu, Donna R. Cousins, Sonali Roy, Dian Guan, Jeremy D. Murray. The role of hormones in rhizobial infection. Biological Nitrogen Fixation, Chapter 56. Editor Frans J. de Bruijn, Wiley-Blackwell, New York, DOI: 10.1002/9781119053095.ch56 (2015). (Book chapter)
24. Andrew Breakspear#, Chengwu Liu#, Sonali Roy, Nicola Stacey, Christian Rogers, Martin Trick, Giulia Morieri, Kirankumar S. Mysore, Jiangqi Wen, Giles E. D. Oldroyd, J. Allan Downie, Jeremy D. Murray*. The root hair infectome of Medicago truncatula uncovers changes in cell cycle genes and reveals a requirement for auxin signaling in rhizobial infection. The Plant Cell 26(12):4680-701 (2014).
25. Ertao Wang*, Nan Yu, S. Asma Bano, ChengwuLiu, Anthony J. Miller, Donna Cousins, Xiaowei Zhang, Pascal Ratet, Million Tadege, Kirankumar S. Mysore, J. Allan Downie, Jeremy D. Murray, Giles E. D. Oldroyd, Michael Schultze. A H+-ATPase that energizes nutrient uptake during mycorrhizal symbioses in rice and Medicago truncatula. ThePlant Cell26(4):1818-1830 (2014).
26. Jeremy D. Murray*, Donna R Cousins, Kirsty J. Jackson, ChengwuLiu. Signaling at the root surface: the role of cutin monomers in mycorrhization. Molecular Plant 6(5):1381-3 (2013).
27. Dian Guan, Nicola Stacey, ChengwuLiu, Jiangqi Wen, Kirankumar S. Mysore, Ivone Torres-Jerez, Tatiana Vernié, Million Tadege, Chuanen Zhou, Zeng-yu Wang, Michael K. Udvardi, Giles E. D. Oldroyd, Jeremy D. Murray*. Rhizobial infection is associated with the development of peripheral vasculature in nodules of Medicago truncatula. Plant Physiology 162(1): 107-115 (2013).
28. Chengwu Liu, Hengfu Yin, Peng Gao, Xiaohe Hu, Jun Yang, Zhongchi Liu, Xiangdong Fu, Da Luo*. PHOSPHATIDYLSERINE SYNTHASE1 is required for inflorescence meristem and organ development in Arabidopsis. Journal of Integrative Plant Biololgy55(8): 682–695 (2013).
29. Hengfu Yin, Peng Gao, ChengwuLiu, Jun Yang, Zhongchi Liu, Da Luo*. SUI-family genes encode phosphatidylserine synthases and regulate stem development in rice. Planta 237(1): 15-27 (2013).
30. Zhi-cheng Dong, Zhong Zhao, Cheng-wuLiu, Jiang-hong Luo, Jun Yang, Wei-hua Huang, Xiao-he Hu, Trevor L. Wang, Da Luo*. Floral patterning in Lotus japonicus. Plant Physiology 137(4): 1272–1282 (2005).
招聘信息
1. 实验室招聘博士后，要求有植物分子生物学、植物细胞生物学或植物生物化学等相关背景、具备独立研究能力，有植物生化研究经验者优先。无截止日期，招到为止。
2. 欢迎对植物发育生物学，植物细胞生物学和植物-微生物共生相关研究有强烈兴趣、善于自我激励（self-motivation）的同学前来实验室攻读研究生。
3. 欢迎对植物发育生物学，植物细胞生物学和植物-微生物共生相关研究感兴趣、且具有强烈上进心的本科生前来实验室进行科研实习。
联系方式
电话：0551-63603105
地址：中国科学技术大学 西校区 生物楼