特任研究员 博士生导师 2020年1月加入中国科学技术大学生命科学与医学部，组建肿瘤神经生物学实验室。目前为中国科学技术大学生命科学学院和附属第一医院双聘青年杰出人才。2012年博士毕业于中国科学技术大学神经生物学专业，2015年至2020年在美国安德森肿瘤研究中心从事博士后研究。近年来以第一作者/共第一作者在Nature Immunology，Nature Metabolism, Nature Cell Biology, JCI, Cell Research，Science Signaling等期刊发表SCI论文10余篇。

主要研究兴趣和方向：

（1）肿瘤免疫治疗耐受产生的分子基础

（2）神经递质与受体在肿瘤免疫代谢微环境中的作用

（3）基于神经性受体分子的抗肿瘤药物开发研究

代表性论文：

（1）Qingsong Hu#, Youqiong Ye#, Li-Chuan Chan#, Ke Liang, Yajuan Li, Kurt Evans, Yinghong Pan, Yaohua Zhang, Weiya Xia, Jiewei Liu, Jing Gong, Sujash Chatterjee, Jun Yao, Aifu Lin, Tina Nguyen, Peter Park, Sergey Egranov, Nagireddy Putluri, Arun Sreekumar, Chandrashekar Ambati, David Hawke, Jeffrey Marks, Preethi Gunaratne, Gabriel Hortobagyi, Funda Meric-Bernstam, Lieping Chen, Dihua Yu, Mien-Chie Hung, Michael Curran, Leng Han*, and Chunru Lin* and Liuqing Yang*. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nature Immunology. 2019.7, 20(7): 835-851.

（2）Qingsong Hu#, Chunlai Li#, Shouyu Wang#, Yajuan Li#, Bo Wen, Yanyan Zhang, Ke Liang, Jun Yao, Youqiong Ye, Heidi Hsiao, Tina K. Nguyen, Peter K. Park, Sergey D. Egranov, David H. Hawke, Jeffrey R. Marks, Leng Han, Mien-Chie Hung, Bing Zhang, Chunru Lin, Liuqing Yang, LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Cell Research. 2019.4, 29(4):286-304.

（3）Youqiong Ye#, Qingsong Hu#, Hu Chen, Ke Liang, Yuan Yuan, Yu Xiang, Hang Ruan, Zhao Zhang, Anren Song, Huiwen Zhang, Lingxiang Liu, Lixia Diao, Yanyan Lou, Liuqing Yang, Bingying Zhou, Li Wang, Jianjun Gao, Eric Jonasch, Stephen H. Lin, Yang Xia, Chunru Lin, Gordon B. Mills*, Han Liang*, Leng Han*, Characterization of Hypoxia-associated Molecular Features for Hypoxia-Targeted Therapy. Nature Metabolism. 2019. 4, 1(4):431-444.

（4）Yajuan Li#, Qingsong Hu#, Chunlai Li#, Ke Liang, Yu Xiang, Heidi Hsiao, Tina K. Nguyen, Peter K. Park, Sergey D. Egranov, Chandrashekar R Ambati, Nagireddy Putluri, David H. Hawke, Leng Han, Mien-Chie Hung, Farhad R. Danesh, Liuqing Yang* and Chunru Lin*. PTEN-induced Partial Epithelial-Mesenchymal Transition Drives Diabetic Kidney Disease. J Clin Invest. 2019.5,    129(3):1129-1151.

（5）Aifu Lin#, Qingsong Hu#, Chunlai Li#, Zhen Xing, Guolin Ma, Cheng Wang, Jun Li, Yin Ye, Jun Yao, Ke Liang, Shouyu Wang, Peter K. Park, Jeffrey R. Marks, Yan Zhou, Jianwei Zhou, Mien-Chie Hung, Han Liang, Zhibin Hu, Hongbing Shen, David H. Hawke, Leng Han, Yubin Zhou, Chunru Lin* & Liuqing Yang*, The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors. Nat Cell Biol. 2017 5, 19(3):238-251.

（6）Shouyu Wang#, Ke Liang#, Qingsong Hu#, Jian Song, Yuedong Yang, Jun Yao, Selanere Mangala, Chunlai Li, Wenhao Yang, Peter K. Park, David H. Hawke, Jianwei Zhou, Yan Zhou, Weiya Xia, Mien-Chie Hung, Jeffery R. Marks, Gary E. Gallick, Gabriel Lopez-Berestein, Elsa R. Flores, Anil K. Sood, Suyun Huang, Dihua Yu, Liuqing Yang* and Chunru Lin*, A JAK2-binding Long Noncoding RNA Promotes Breast Cancer Brain Metastasis. J Clin Invest. 2017.12, 127(12):4498-4515.

（7）Hu Q, Li B, Xu R, Chen D, Mu C, Fei E, Wang G*, The Protease Omi Cleaves the Mitogen-Activated Protein Kinase Kinase MEK1 to Inhibit Microglial Activation. Sci Signal. 2012.8, 5(238):ra61.

（8）Qingsong Hu and Guanghui Wang, Mitochondrial dysfunction in Parkinson’s disease. Translational Neurodegeneration. 2016.7, 5:14.

（9）Wu JY, Li M, Cao LJ, Sun ML, Chen D, Ren HG, Xia Q, Tao ZT, Qin ZH, Hu QS*, Wang GH*, Protease Omi Cleaving Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cells and cerebral injury in MCAO mice. Acta Pharmacol Sin. 2015.9, 36(9):1043-52.

（10）Chao Gu#, Qingsong Hu#, Jiayuan Wu#, Chenchen Mu, Haigang Ren, Chun-Feng Liu and Guanghui Wang*. P7C3 Inhibits LPS-Induced Microglial Activation to Protect Dopaminergic Neurons Against Inflammatory Factor-Induced Cell Death in vitro and in vivo. Front Cell Neuroscience. 2018.11, 12:400.

招生招聘：

1． 实验室招聘具有免疫、细胞生物学、神经生物学或生物信息学等相关背景的博士后和特任副研究员；

2． 实验室欢迎对肿瘤免疫以及肿瘤神经生物学感兴趣的学生前来攻读博士学位或实习；

3． 招聘研究助理1名，硕士或以上学历，负责实验室基本管理，协助课题组成员开展科研工作；

4． 招聘实验室管理员1名，本科或以上学历，有实验室管理或科研经验者优先考虑。

联系方式：

E-mail: qshu@ustc.edu.cn