主要研究兴趣:
摄食是动物和人获取能量和营养的唯一方式,吃多吃少决定了机体的健康,对体重,代谢,免疫,甚至寿命都有非常重要的影响。神经系统在摄食和代谢调控中占据主导地位。我们实验室将从神经系统如何感知机体营养状态;如何调控摄食行为;如何基于机体的营养状态调控代谢、免疫和寿命等几个方面着手,研究神经调控摄食的机制及对健康的影响。研究方向主要归纳为如下两点:
1) 神经调控摄食和能量代谢的机制。
2) 神经-免疫-代谢的反馈调节机制。
特任教授 博士生导师 2018年获基金委优秀青年基金支持。2021年加入中国科学与技术大学。近年来以第一/通讯作者身份在Neuron,Current Biology, PNAS,Journal of Neuroscience等国际知名杂志发表多篇论文,累计他引1000余次,h-index 9,最高单篇他引290余次(截至2021年,Google Scholar)。现任中国生理学会青年工作委员会和自主神经分会委员,中国神经生物学会应激分会委员。
代表性学术论文:
1、Jing Chen, Minxiu Cheng, Liang Wang, Lei Zhang, Dan Xu, Peng Cao, Fengchao Wang, Herbert Herzog, Sen Song, Cheng Zhan#. A vagal-NTS neural pahway that stimulates feeding. Current Biology(2020). # corresponding author
2、L. Mei, Y.Fan , M. Wang, X. Lv , C. Zhan#, E. Zhang#. Longitudinal in vivo recording of clock gene transcription in the brains of freely-moving mice. PNAS (2018). #co-corresponding author.
3、L. Mei , C. Zhan , E. Zhang. In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters. JOVE (2018).
4、Z. Zhao, L. Wang, W. Gao, F. Hu, J. Zhang, Y. Ren, R. Lin, Q. Feng, M. Cheng, D. Ju, Q. Chi, D. Wang, S. Song, M. Luo and C. Zhan# (2017). A Central Catecholaminergic Circuit Controls Blood Glucose Levels during Stress. Neuron 95, 138-152 e135. Featured Article. # corresponding author.
5、D. Wang, X. He, Z. Zhao, Q.Feng, R.Lin, Y. Sun, T. Ding, F. Xu #, M. Luo #, C. Zhan # (2015) Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons. Frontiers in Neuroanatomy 9:40. # co-corresponding author.
6、C. Zhan*#, J. Zhou *, Q. Feng, J. Zhang, S. Lin, J. Bao, P. Wu, M. Luo #, Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively. J Neurosci 33:3624-3632, 2013. Selected for F1000Prime. # co-corresponding author, *co-fist author,.
7、C. Zhan, M. Luo, Diverse patterns of odor representation by neurons in the anterior piriform cortex of awake mice. J Neurosci 30, 16662-16672, 2010.
综述文章
1、占成,摄食行为的神经调控。中国科学.生命科学,2020年。
2、Zhan C. POMC Neurons: Feeding, Energy Metabolism, and Beyond. In Neural Regulation of Metabolism. 2018 (pp. 17-29). Springer, Singapore.
联系方式:
招生招聘:
实验室招聘生物或者医学背景的博士后和特任副研究员,同时欢迎上述背景的学生来本实验室攻读博士学位。