周敏

周敏

2021-12-04来源:生命科学与医学部



中国科学技术大学生命科学与医学部教授,中国科学技术大学附属第一医院重症医学科主任,主任医师,医学博士,UCLA博士后,博士生导师,国家自然基金委函审专家。


一、学习及工作经历

教育经历:

1989--1994年,安徽医科大学,临床医学系,本科;

2003--2006年,安徽医科大学,免疫学系,硕士;

2011--2015年,安徽医科大学,呼吸系,博士;

2014--2015年,美国加州大学洛杉矶分校(UCLA),博士后;

 

工作经历:

2006--2016年,安徽医科大学第一附属医院,副主任医师;

2017--至今,中国科学技术大学附属第一医院,科主任/主任医师;

 

二、学术成果及影响

迄今,以通讯/第一作者在Hepatology.Front. Immunol.Neuroendocrinology.Neurocrit. Care.J. Inflamm. Res.SCI论文共30余篇,受邀撰写综述性论文3篇,受邀撰写重症医学著作和指南共5篇,多次受邀在国内外重症医学会、神经重症医学会等会议作邀请报告。主持的主要项目包括国家自然科学基金面上项目和重点项目共3项,安徽省自然科学基金重点项目1项,科大新医学基金1项。获国家发明专利2项、2020安徽省五一巾帼标兵荣誉称号等奖项、2008年安徽省科技进步三等奖、指导中科大附一院新技术新项目2项。


三、在研项目(仅限于主要负责人)

 

项目名称、来源、经费指标卡号

总经费(万元)

起止日期

基因修饰β-catenin/Notch信号靶向调控ES-DC的免疫反应对脓毒症急性肺损伤的保护作用及机制(2023年国家自然科学基金,82241050

61

202301月至202512

 

四、主要研究方向(招生专业)及内容

研究工作主要集中在免疫/细胞生物学、脓毒症的基础与临床研究、肺损伤的神经免疫调控、脑功能和脑疾病的机制研究等

招生专业:临床医学1、重症医学(方向二);2、呼吸内科学(方向二)


五、代表性论文(近五年)

1. Mukerabigwi JF, Tang R, Cao Y, Mohammed F, Zhou Q, Zhou M*, Ge Z*. Mitochondria-Targeting Polyprodrugs to Overcome the Drug Resistance of Cancer Cells by Self-Amplified Oxidation-Triggered Drug Release. Bioconjug Chem. 2023 Feb 15;34(2):377-391.

2. Liu S, Lin K, Zhang Y, Gao Y, Wang W, Du M, Jiang T*, Zhou M*, Zhang X*. Prevalence and risk factors of psychotic symptoms in middle-aged patients with first-episode drug-naïve major depressive disorder: A large-scale cross-sectional study. J Affect Disord. 2023 Mar 15;325:102-109.

3. Min Zhou, Min Du, Rui Tang, Hai-Yan Liu, Zhi Gao, Ying Wang, He-Yang You, Ji-Wei Hao, Zong-Shu Ji, Di Wan, Qing-Hong Zhang*. Central GLP-1 Resistance Induced by Severe Traumatic Brain Injury Was Associated with Persistent Hyperglycemia in Humans[J]. Neuroendocrinology, 2023, 113(6): 625-640.

4. Min DuQing-Hong Zhang, Rui Tang, Hai-Yan Liu, Zong-Shu Ji, Zhi Gao, Ying Wang, He-Yang You, Ji-Wei Hao, Min Zhou*. Prognostic significance of plasma insulin level for deep venous thrombosis in patients with severe traumatic brain injury in critical care[J]. Neurocritical Care, 2023, 38(2): 263-278.

5. Liu L, Cheng Y, Zhang F, Chen J, Tian P, Shi W, Zhou F, Yang M, Zhou M, Liu B*. IL-2/GM-CSF enhances CXCR3 expression in CAR-T cells via the PI3K/AKT and ERK1/2 pathways. J Cancer Res Clin Oncol. 2023 Aug;149(9):5547-5557.

6. Yu M#, Zhou M#, Li J, Zong R, Yan Y, Kong L et al. Notch-activated mesenchymal stromal/stem cells enhance the protective effect against acetaminophen-induced acute liver injury by activating AMPK/SIRT1 pathway. Stem Cell Research & Therapy 2022; 13(1):1–17.

7. Liu H, Zhou M*. The utility of therapeutic hypothermia on cerebral autoregulation. J Intensive Med. 2022 Oct 4;3(1):27-37.

8. Zhou M, Zhang Y, Tang R, Liu H, Du M, Gao Z, Ji Z, Fang H*. HMGB1/TLR4 Signaling Affects Regulatory T Cells in Acute Lung Injury. J Inflamm Res. 2021 Apr 19;14:1551-1561.

9.  Liu L, Yang M, Xu Q, Zhou M, Cheng Y, Xu H, Qin Y, Liu B*. Killing efficiency affected by mutually modulated PD-1 and PD-L1 expression via NKT-hepatoma cell interactions. Immunotherapy. 2021 Feb;13(2):113-123.

10.  Ke W, Lu N, Japir AAMM, Zhou Q, Xi L, Wang Y, Dutta D, Zhou M*, Pan Y*, Ge Z*. Length effect of stimuli-responsive block copolymer prodrug filomicelles on drug delivery efficiency. J Control Release. 2020 Feb; 318:67-77.

11. Dutta D, Ke W, Xi L, Yin W, Zhou M*, Ge Z*. Block copolymer prodrugs: Synthesis, self-assembly, and applications for cancer therapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Jan;12(1):e1585.

12. Liu L , Yang M , Xu Q , Zhou M , Liu, B*. Killing efficiency affected by mutually modulated PD-1 and PD-L1 expression via NKT-hepatoma cell interactions[J].Immunotherapy, 2020 13(2):113-123.

13. Mohammed F, Ke W, Mukerabigwi JF, M Japir AAM, Ibrahim A, Wang Y, Zha Z, Lu N, Zhou M*, Ge Z*. ROS-Responsive Polymeric Nanocarriers with Photoinduced Exposure of Cell-Penetrating Moieties for Specific Intracellular Drug Delivery. ACS Appl Mater Interfaces. 2019 Sep 4;11(35):31681-31692.

14. Zhou M, Fang H, Du M, Li C, Tang R, Liu H et al. The Modulation of Regulatory T Cells via HMGB1/PTEN/β-Catenin Axis in LPS Induced Acute Lung Injury. Front Immunol 2019; 10:1612.

15. Ji XJ, Hao JW, Li GL, Dong N, Wang XQ, Zhou M, Zhang QH, Yao YM*. Exendin-4 Exacerbates Burn-Induced Morbidity in Mice by Activation of the Sympathetic Nervous System. Mediators Inflamm. 2019 Jan 17;2019:2750528.


六、联系方式

E-mail: dminzhou@ustc.edu.cn

电话:0551-62284902


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