主要研究领域
利用细胞分子生物学，生物信息学，生物化学等手段，主要研究：
1. 表观遗传异常在肿瘤发生发展过程中的生物学功能和作用分子机制；
2. 细胞衰老和组织老化中的表观遗传改变及其在肿瘤发生中的作用；
3. 表观遗传分子作为潜在靶点的抗肿瘤药物、抗衰老药物开发。
特任教授，博士生导师，国家青年创新人才计划获选者。2007年本科毕业于中央民族大学，2012年博士毕业于北京大学。2012年9月至2021年6月，美国约翰霍普金斯大学医学院Sidney Kimmel综合癌症中心任博士后研究员和Research Associate。
2021年加入中国科学技术大学生命科学与医学部，组建肿瘤表观遗传学实验室。相关成果在Cancer Cell, PNAS, Stem Cells, Nature, Molecular Cell等杂志发表，并获得Nature Reviews Cancer、Science Daily和F1000Prime等的专题报道和推荐。
获奖情况
2009年北京大学康宁博士奖学金
2011年北京大学康宁博士奖学金
2012年北京大学优秀毕业生
2018年Keystone Symposia Future of Science Fund Scholarship, Keystone Symposia
2019年国家青年创新人才计划
发表论文(#equal first authorship)
Wenbing Xie, Ioannis Kagiampakis, Lixia Pan, Yang W. Zhang, Lauren Murphy, Xiangqian Kong, Limin Xia, Fillipe LF Carvlho, Subhojit Sen, Ray-Whay Chiu Yen, Cynthia A. Zahnow, Nita Ahuja, Stephen B. Baylin* and Hariharan Easwaran*. “DNA methylation patterns separate senescence from transformation potential and indicate cancer risk”. Cancer Cell. 2018 Feb 12; 33(2):309-321.e5. (Highlighted in Nature Reviews Cancer)
Xiangqian Kong#, Jie Chen#, Wenbing Xie#, Stephen M. Brown, Yi Cai, Kaichun Wu, Daiming Fan, Yongzhan Nie, Rochelle L. Tiedemann, Yong Tao, Ray-Whay Chiu Yen, Michael J. Topper, Cynthia A. Zahnow, Hariharan Easwaran, Scott B. Rothbart*, Limin Xia*, Stephen B. Baylin*. “Defining UHRF1 Domains That Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties”. Cancer Cell. 2019 Apr 15;35(4):633-648 (Featured as an NIEHS Extramural Paper of the Month: May 2019)
Wenbing Xie, Stephen B. Baylin, Hariharan Easwaran. “DNA methylation in senescence, aging and cancer”. Oncoscience. 2019; 6 (1): 291-293.
Wenbing Xie#, Te Ling#, Yonggang Zhou#, Weijun Feng, Qiaoyun Zhu, Henk Stunnenberg, Ingrid Grummt and Wei Tao. The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions. Proc Natl Acad Sci U.S.A. 2012; 109(21): 8161-8166.
Min Luo#, Te Ling#, Wenbing Xie#, He Sun#, Yonggang Zhou, Qiaoyun Zhu, Meili Shen, Le Zong, Guoliang Lyu, Yun Zhao, Tao Ye, Jun Gu, Wei Tao, Zhigang Lu and Ingrid Grummt. NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells. Stem Cells. 2013; 31(7): 1278-1286.
Te Ling#, Wenbing Xie#, Min Luo#, Meili Shen, Qiaoyun Zhu, Le Zong, Tingting Zhou, Jun Gu, Zhigang Lu, Feixiong Zhang and Wei Tao. CHD4/NuRD maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5. Biochem Biophys Res Commun. 2013; 437(1): 101-107.
Zhihao Lu#, Jianling Zou#, Shuang Li#, Michael J. Topper, Yong Tao, Hao Zhang, Xi Jiao, Wenbing Xie, Xiangqian Kong, Michelle Vaz, Huili Li, Yi Cai, Limin Xia, Kristen Rodgers, Beverly Lee, Joanne B. Riemer, Xi Jiao, Ray-Whay Chiu Yen, Chi-Ping Day, Weiqiang Zhang, Ying Cui, Hariharan Easwaran, Alicia Hulbert, KiBem Kim, Shibin Zhou, Stephen C. Yang, Richard J. Battafarano, Errol L. Bush, Stephen R. Broderick, Stephen M. Cattaneo, Julie R. Brahmer, Charles M. Rudin, John Wrangle, Yuping Mei, Young J. Kim, Bin Zhang, Ken Kang-Hsin Wang, Patrick M. Forde, Joseph B. Margolick, Barry D. Nelkin, Cynthia A. Zahnow, Drew M. Pardoll1, Franck Housseau, Stephen B. Baylin*, Lin Shen*, Malcolm V. Brock*. “Epigenetic therapy inhibits metastases by disrupting premetastatic niches”. Nature. 2020 Mar;579(7798):284-290. (News and Views in Nature)
Yong Tao#, Byunghak Kang#, Daniel Petkovich, Julie In, Genevieve Stein-O'Brien, Xiangqian Kong, Wenbing Xie, Nicholas Zachos, Shinji Maegawa, Stephen Brown, Ray-Whay Chiu Yen, Jai Thakor, Zhihao Lu, Yuezheng Zhang, Izaskun Mallona Gonzalez, Miguel Angel Peinado, Cynthia A. Zahnow, Nita Ahuja, Elana Fertig, Jean-Pierre Issa, Stephen B. Baylin*, Hariharan Easwaran*. “Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis”. Cancer Cell. 2019 February 11; 35(2): 315-328.e6. (F1000Prime recommended; Previewed in Cancer Cell)
Fei Ye#, Xiangqian Kong#, Shijie Chen, Hao Zhang, Yan Liu, Zhiyuan Shao, Jia Jin, Yi Cai, Rukang Zhang, Linjuan Li, Yang W. Zhang, Yu-Chih Liu, Chenhua Zhang, Wenbing Xie, Kunqian Yu, Hong Ding, Kehao Zhao, Hualiang Jiang, Stephen B. Baylin* and Cheng Luo*. “Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1”. ACS Chemical Biology. 2018 Mar 16;13(3):772-781.
Guoliang Lyu#, Le Zong#, Chao Zhang, Xiaoke Huang, Wenbing Xie, Junnan Fang, Yiting Guan, Lijun Zhang, Ting Ni, Jun Gu, Wei Tao. “Metastasis-related methyltransferase Merm1 represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase I transcriptional elongation”. Journal of Molecular Cell Biology. 2018; doi.org/10.1093/jmcb/mjy023.
Limin Xia#, Wenjie Huang#, Marina Bellani, Michael M. Seidman, Kaichun Wu, Daiming Fan, Yongzhan Nie, Yi Cai, Yang W. Zhang, Lirong Yu, Huili Li, Cynthia A. Zahnow, Wenbing Xie, Ray-Whay Chiu Yen, Feyruz V. Rassool, Stephen B. Baylin. “CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes”. Cancer Cell. 2017; 31: 653–668. DOI: 10.1016/j.ccell.2017.04.005.
Yang W. Zhang, Zhihong Wang, Wenbing Xie, Yi Cai, Limin Xia, Hariharan Easwaran, Jianjun Luo, Ray-Whay Chiu Yen, Yana Li, Stephen B. Baylin. “Acetylation enhances TET2 function in protecting against abnormal DNA methylation during oxidative stress”. Molecular Cell. 2017; 65(2):323-335.
Shijiao Huang, Xiaowei Xu, Guopeng Wang, Guoliang Lu, Wenbing Xie, Wei Tao, Hongyin Zhang, Qing Jiang and Chuanmao Zhang. “DNA Replication Initiator Cdc6 also Regulates Ribosomal DNA Transcription Initiation.” J Cell Sci. 2016; 129: 1429-1440.
Lixia Pan, Wenbing Xie, Kai-Le Li, Zhihao Yang, Jiang Xu, Wenhao Zhang, Lu-Ping Liu, Xingjie Ren, Zhimin He, Junyu Wu, Jin Sun, Hui-Min Wei, Da-Liang Wang, Wei Xie, Wei Li, Jian-Quan Ni*, and Fang-Lin Sun*. Heterochromatin remodeling by CDK12 contributes to learning in Drosophila. Proc Natl Acad Sci U.S.A. 2015; 112(45): 13988-13993.
招生招聘
实验室诚聘具有细胞分子生物学、生物信息学、生物化学等相关背景的特任副研究员和博士后。同时，热忱欢迎对肿瘤表观遗传学感兴趣的本科生来攻读博士学位。长期招聘，请email联系。
联系方式：wxie6@ustc.edu.cn