李娟

李娟

2022-01-10来源:临床医学院


1966.5,医学博士,博士生导师,主任医师,中国科学技术大学附属第一医院麻醉科科室副主任,中国医师协会麻醉学医师分会常务委员,中国心胸血管麻醉学分会胸科分会副主任委员,中国医药教育协会麻醉专业委员会常委,中国神经科学学会麻醉与脑功能分会常委,《中华麻醉学杂志》通讯编委,《临床麻醉学杂志》编委。2019年荣获“第七批省学术和技术带头人”称号,获得安徽省科学技术二等奖一项,三等奖5项。作为临床医生,一直注重临床与基础研究相结合,发表论文100多篇,其中SCI 40篇,主要研究成果发表在nature neuroscienceneuropetides等期刊。


一、学习及工作经历

  • 1984--1989年,安徽医科大学,医疗专业,医学学士;

  • 1997--2000年,安徽医科大学,药理专业,药理学硕士

  • 2003--2008年,安徽医科大学,药理专业,药理学博士

  • 1989--1994年,安徽省立医院麻醉科,住院医师

  • 1995--2002年,安徽省立医院麻醉科,主治医师

  • 2002--2010年,安徽省立医院麻醉科,副主任医师

  • 2010年—至今,安徽省立医院麻醉科,主任医师

  • 2010年—至今,中国科学技术大学附属第一医院麻醉科,科室副主任


二、学术成果及影响

 从事临床麻醉工作30多年,一直坚持临床和基础研究相结合,已培养博士8名、硕士研究生15名。获省级科学技术进步二等奖一项,三等奖5项。

 近五年在nature neuroscience等学术期刊(SCI)以通讯作者发表论文14余篇。


三、在研项目(仅限于主要负责人)

项目名称、来源、经费指标卡号

总经费(万元)

起止日期

Delta阿片系统在骨癌痛镇痛中的作用及机制研究,中国科学技术大学“新医学”重点项目中国科学技术大学“新医学”重点项目

80

2019-122022-12

SIRT1介导骨癌痛产生的表观遗传学机制研究,安徽省自然基金项目

10

2019-122022-12


四、主要研究方向(招生专业)及内容

临床医学

1、临床研究

1)围术期重要脏器的保护;

2)经皮穴位电刺激对围术期并发症的影响;

2、基础研究

1)脑、肾脏缺血再灌注损伤的机制研究;

2) δ阿片受体介导癌痛的镇痛机制研究

3不同病因引起的疼痛特定神经环路的研究


五、代表性论文(近五年)

1、Xia Zhu#, Hao-Di Tang#,Wan-Ying Dong#, Fang Kang#, An Liu, Yu MaoWen Xie, Xulai Zhang, Peng Cao, Wenjie Zhou, Haitao Wang, Zahra Farzinpour, Wenjuan Tao, Xiaoyuan Song, Yan Zhang, Tian Xue, Yan Jin*, Juan Li*,and Zhi Zhang*. Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states. Nature Neuroscience,   https://doi.org/10.1038/s41593-021-00811-x2021.

2、Chengwei Yang, Fang Kang , Wenjun Meng, Meirong Dong, XiangHuang, Sheng Wang, Zhiyi Zuo*, Juan Li*. Minimum alveolar concentration-awake of sevoflurane is decreased in patients with Parkinson’s disease: an up-and-down sequential allocation trial. Clinical Interventions in Aging, 2021:16 129–137.

3、Han M, Kang F, Yang C, Liu Z, Wang T, Zhai M, Li J*. Comparison of Adrenaline and Dexmedetomidine in Improving the Cutaneous Analgesia of Mexiletine in Response to Skin Pinpricks in Rats[J]. Pharmacology 2020:1-7.

4、Chengwei Yang, Yuanyuan Feng, Sheng Wang, Mingming Han, Song Wang, Fang Kang, Xiang Huang, Juan Li*, Effect of sex differences in remifentanil requirements for inhibiting the response to a CO2 pneumoperitoneum during propofol anesthesia: an up-and-down sequential allocation trial, BMC Anesthesiol, 2020 Feb 3;20(1):35.

5、Yang C#, Huang X#, Wang S, Han M, Kang F, Zhang Z*, Li J*. Intrathecal administration of SRT1720 relieves bone cancer pain by inhibiting the CREB/CRTC1 signalling pathway. Neuroscience letters 2020; 715: 134623.

6、Lingsuo Kong,Qing WeiXianwen HuLanren ChenJuan Li*miR-193a-3p Promotes Radio-Resistance of Nasopharyngeal Cancer Cells by Targeting SRSF2 Gene and Hypoxia Signaling PathwayMed Sci Monit Basic Res, 201925:53-62

7、Chengwei Yang, Fang Kang, Sheng Wang, Mingming Han, Zhi Zhang, Juan Li*. SIRT1 Activation Attenuates Bone Cancer Pain by Inhibiting mGluR1/5, Cellular and molecular neurobiology, 2019 Nov;39(8):1165-1175

8、Xi bei Hu, Zhi yu Xi, Lin qing Liu, Kai Kang, Wan hong Li, Yu xian Shen, Fang Kang, Juan Li*. Dexmedetomidine Promotes SH-SY5Y Cell Resistance Against Impairment of Iron Overload by Inhibiting NF-κB Pathways.Neurochemical Research, 29 January 2019, 44(4)959-967.

9、Mingming Han, Fushan Xue, Fang Kang, Xiang Huang, Juan Li*.Male requires a higher median target effect-site concentration of propofol for I-gel placement when combined with dexmedetomidine, Anaesth Crit Care Pain Med 2019 Feb;38(1):57-61.

10、Qijian Li, Chaojin Chen, Xi Chen, Mingming Han, Juan Li*. Dexmedetomidine attenuates renal fibrosis via α2-adrenergic receptor-dependent inhibition of cellular senscence after renal ischema/reperfusion. Life Sci. 2018, 207:1-8.

11、Fang Kang, ChaoLiang Tang MingMing Han, XiaoQing Chai, Qiang Huang, Juan Li*. Effects of Dexmedetomidine-Isoflurane versus Isoflurane Anesthesia on Brain Injury After Cardiac Valve Replacement Surgery. J Cardiothorac Vasc Anesth. 2018 Aug;32(4): 1581-1586.

12、Ming-Ming Han, Cheng-Wei Yang, Chi-Wai Cheung, Juan Li*. Blockage of spinal endothelin A receptors attenuates bone cancer pain via regulation of the Akt/ERK signaling pathway in mice. Neuropeptides, 2018; 68: 36-42.

13、Jia Yang, Zhijun Chen, Xinyi Wang, Mo Xu, Haoshu Fang, Feifei Li, Yakun Liu,Yu Jiang, Yi Ding, Juan Li*& Siying Wan. Inactivation of miR-100 combined with arsenic treatment enhances the malignant transformation of BEAS-2B cells via stimulating epithelial -mesenchymal transition. Cancer Biology & Therapy, 2017, VOL. 18, NO. 12, 965–973.

14、Mingyu Zhai, MM, Fang Kang, MD, Mingming Han,MM, Xiang Huang, MM, Juan Li*, PhD. The effect of dexmedetomidine on renal function in patients undergoing cardiac valve replacement under cardiopulmonary bypass: A double-blind randomized controlled trial. Journal of Clinical Anesthesia 40 (2017) 33–38.


六、联系方式

E-mail: huamuzi1999@126.com

电话:0551-62284460


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