1966.5,医学博士,博士生导师,主任医师,中国科学技术大学附属第一医院麻醉科科室副主任,中国医师协会麻醉学医师分会常务委员,中国心胸血管麻醉学分会胸科分会副主任委员,中国医药教育协会麻醉专业委员会常委,中国神经科学学会麻醉与脑功能分会常委,《中华麻醉学杂志》通讯编委,《临床麻醉学杂志》编委。2019年荣获“第七批省学术和技术带头人”称号,获得安徽省科学技术二等奖一项,三等奖5项。作为临床医生,一直注重临床与基础研究相结合,发表论文100多篇,其中SCI 40篇,主要研究成果发表在nature neuroscience、neuropetides等期刊。
一、学习及工作经历
1984年--1989年,安徽医科大学,医疗专业,医学学士;
1997年--2000年,安徽医科大学,药理专业,药理学硕士
2003年--2008年,安徽医科大学,药理专业,药理学博士
1989年--1994年,安徽省立医院麻醉科,住院医师
1995年--2002年,安徽省立医院麻醉科,主治医师
2002年--2010年,安徽省立医院麻醉科,副主任医师
2010年—至今,安徽省立医院麻醉科,主任医师
2010年—至今,中国科学技术大学附属第一医院麻醉科,科室副主任
二、学术成果及影响
从事临床麻醉工作30多年,一直坚持临床和基础研究相结合,已培养博士8名、硕士研究生15名。获省级科学技术进步二等奖一项,三等奖5项。
近五年在nature neuroscience等学术期刊(SCI)以通讯作者发表论文14余篇。
三、在研项目(仅限于主要负责人)
项目名称、来源、经费指标卡号 | 总经费(万元) | 起止日期 |
Delta阿片系统在骨癌痛镇痛中的作用及机制研究,中国科学技术大学“新医学”重点项目中国科学技术大学“新医学”重点项目 | 80 | 2019-12至2022-12 |
SIRT1介导骨癌痛产生的表观遗传学机制研究,安徽省自然基金项目 | 10 | 2019-12至2022-12 |
四、主要研究方向(招生专业)及内容
临床医学
1、临床研究
1)围术期重要脏器的保护;
2)经皮穴位电刺激对围术期并发症的影响;
2、基础研究
1)脑、肾脏缺血再灌注损伤的机制研究;
2) δ阿片受体介导癌痛的镇痛机制研究
3)不同病因引起的疼痛特定神经环路的研究
五、代表性论文(近五年)
1、Xia Zhu#, Hao-Di Tang#,Wan-Ying Dong#, Fang Kang#, An Liu, Yu Mao,Wen Xie, Xulai Zhang, Peng Cao, Wenjie Zhou, Haitao Wang, Zahra Farzinpour, Wenjuan Tao, Xiaoyuan Song, Yan Zhang, Tian Xue, Yan Jin*, Juan Li*,and Zhi Zhang*. Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states. Nature Neuroscience, https://doi.org/10.1038/s41593-021-00811-x,2021.
2、Chengwei Yang, Fang Kang , Wenjun Meng, Meirong Dong, XiangHuang, Sheng Wang, Zhiyi Zuo*, Juan Li*. Minimum alveolar concentration-awake of sevoflurane is decreased in patients with Parkinson’s disease: an up-and-down sequential allocation trial. Clinical Interventions in Aging, 2021:16 129–137.
3、Han M, Kang F, Yang C, Liu Z, Wang T, Zhai M, Li J*. Comparison of Adrenaline and Dexmedetomidine in Improving the Cutaneous Analgesia of Mexiletine in Response to Skin Pinpricks in Rats[J]. Pharmacology 2020:1-7.
4、Chengwei Yang, Yuanyuan Feng, Sheng Wang, Mingming Han, Song Wang, Fang Kang, Xiang Huang, Juan Li*, Effect of sex differences in remifentanil requirements for inhibiting the response to a CO2 pneumoperitoneum during propofol anesthesia: an up-and-down sequential allocation trial, BMC Anesthesiol, 2020 Feb 3;20(1):35.
5、Yang C#, Huang X#, Wang S, Han M, Kang F, Zhang Z*, Li J*. Intrathecal administration of SRT1720 relieves bone cancer pain by inhibiting the CREB/CRTC1 signalling pathway. Neuroscience letters 2020; 715: 134623.
6、Lingsuo Kong,Qing Wei,Xianwen Hu,Lanren Chen, Juan Li*,miR-193a-3p Promotes Radio-Resistance of Nasopharyngeal Cancer Cells by Targeting SRSF2 Gene and Hypoxia Signaling Pathway,Med Sci Monit Basic Res, 2019;25:53-62
7、Chengwei Yang, Fang Kang, Sheng Wang, Mingming Han, Zhi Zhang, Juan Li*. SIRT1 Activation Attenuates Bone Cancer Pain by Inhibiting mGluR1/5, Cellular and molecular neurobiology, 2019 Nov;39(8):1165-1175
8、Xi bei Hu, Zhi yu Xi, Lin qing Liu, Kai Kang, Wan hong Li, Yu xian Shen, Fang Kang, Juan Li*. Dexmedetomidine Promotes SH-SY5Y Cell Resistance Against Impairment of Iron Overload by Inhibiting NF-κB Pathways.Neurochemical Research, 29 January 2019, 44(4): 959-967.
9、Mingming Han, Fushan Xue, Fang Kang, Xiang Huang, Juan Li*.Male requires a higher median target effect-site concentration of propofol for I-gel placement when combined with dexmedetomidine, Anaesth Crit Care Pain Med 2019 Feb;38(1):57-61.
10、Qijian Li, Chaojin Chen, Xi Chen, Mingming Han, Juan Li*. Dexmedetomidine attenuates renal fibrosis via α2-adrenergic receptor-dependent inhibition of cellular senscence after renal ischema/reperfusion. Life Sci. 2018, 207:1-8.
11、Fang Kang, ChaoLiang Tang MingMing Han, XiaoQing Chai, Qiang Huang, Juan Li*. Effects of Dexmedetomidine-Isoflurane versus Isoflurane Anesthesia on Brain Injury After Cardiac Valve Replacement Surgery. J Cardiothorac Vasc Anesth. 2018 Aug;32(4): 1581-1586.
12、Ming-Ming Han, Cheng-Wei Yang, Chi-Wai Cheung, Juan Li*. Blockage of spinal endothelin A receptors attenuates bone cancer pain via regulation of the Akt/ERK signaling pathway in mice. Neuropeptides, 2018; 68: 36-42.
13、Jia Yang, Zhijun Chen, Xinyi Wang, Mo Xu, Haoshu Fang, Feifei Li, Yakun Liu,Yu Jiang, Yi Ding, Juan Li*& Siying Wan. Inactivation of miR-100 combined with arsenic treatment enhances the malignant transformation of BEAS-2B cells via stimulating epithelial -mesenchymal transition. Cancer Biology & Therapy, 2017, VOL. 18, NO. 12, 965–973.
14、Mingyu Zhai, MM, Fang Kang, MD, Mingming Han,MM, Xiang Huang, MM, Juan Li*, PhD. The effect of dexmedetomidine on renal function in patients undergoing cardiac valve replacement under cardiopulmonary bypass: A double-blind randomized controlled trial. Journal of Clinical Anesthesia 40 (2017) 33–38.
六、联系方式
E-mail: huamuzi1999@126.com
电话:0551-62284460