特任研究员，博士生导师。2015年本科毕业于华中科技大学，2019年博士毕业于清华大学。2019-2022年于西湖大学先后任博士后、助理研究员。2022年11月加入中国科学技术大学生命科学与医学部，组建大分子机器结构与功能实验室。课题组主要利用生物化学和结构生物学等手段，研究参与重要生命过程、与重大疾病相关的大分子机器的工作机理，揭示相关人类疾病的致病机制，促进新药研发。至今，已在Cell、Science、Molecular Cell、Cell Research、Nature Structural & Molecular Biology等期刊发表多篇高水平研究论文。
主要研究方向：
（1）RNA加工、转运和作用的分子机制；
（2）细胞内其它重要生物大分子机器的结构与功能。
代表性论文(*first author, #corresponding author)
2. Xiechao Zhan*, Chuangye Yan*, Xiaofeng Zhang*, Jianlin Lei and Yigong Shi# (2018). Structure of a Human Catalytic Step I Spliceosome. Science
3. Xiaofeng Zhang*, Chuangye Yan*, Xiechao Zhan*, Lijia Li, Jianlin Lei and Yigong Shi# (2018). Structure of the Human Activated Spliceosome in Three Conformational States. Cell Research (Cover Story)
4. Xiaofeng Zhang*, Chuangye Yan*, Xiechao Zhan*, Wenyu Zhang*, Dongliang Liu, Jianlin Lei and Yigong Shi# (2019). Structures of the human spliceosomes before and after release of the ligated exon. Cell Research
5. Jianhua Luo*, Qi Yang*, Xiaofeng Zhang*, Yuanyuan Zhang*, Li Wan*, Xiechao Zhan, Yao Zhou, Liuqing He, Dnayang Li, Dazhi Jin, Ying Zhen, Jing Huang, Min Dong, Yanyan Li#, and Liang Tao# (2022). TFPI is an intestinal glandular receptor for C. difficile toxin B from the hypervirulent clade 2 lineages. CELL
6. Xiaofeng Zhang*#, Fenghua Yang*, Xiechao Zhan*, Tong Bian*, Zhihan Xing, Yichen Lu and Yigong Shi# (2023). Structural Basis of Pre-tRNA Intron Removal by Human tRNA Splicing Endonuclease. Molecular Cell
7. Xiaofeng Zhang*#, Xiechao Zhan*, Tong Bian*, Fenghua Yang*, Pan Li, Yichen Lu, Zhihan Xing, Rongyan Fan, Qiangfeng Zhang, Yigong Shi# (2024). Structural Insights into Branch Site Proofreading by Human Spliceosome. Nature Structural & Molecular Biology
8. Xiechao Zhan*, Chuangye Yan*, Xiaofeng Zhang*, Wenyu Zhang, Jianlin Lei and Yigong Shi# (2018). Structures of the human pre-catalytic spliceosome and its precursor spliceosome. Cell Research
9. Lorenzo Finci#, Xiaofeng Zhang, Xiuliang Huang, Qiang Zhou, Jennifer Tsai, Teng Teng, Betty Chan, Sean Irwin, Craig Karr, Andrew Cook, Silvia Buonamici, and Nicholas A. Larsen# (2018). The Cryo-EM Structure of the SF3b Spliceosome Complex Bound to a Splicing Modulator Reveals a Pre-mRNA Substrate Competitive Mechanism of Action. Genes & Development
10. Xiechao Zhan, Yicheng Lu, Xiaofeng Zhang, Chuanye Yan and Yigong Shi# (2022). Mechanism of exon ligation by human spliceosome. Molecular Cell
11. Wenyu Zhang, Xiaofeng Zhang, Xiechao Zhan, Rui Bai, Jianlin Lei, Chuangye Yan, Yigong Shi# (2024). Structural insights into human exon-defined spliceosome prior to activation. Cell Research
12. Chengcheng Wang#, Zhouyan Guo, Xiechao Zhan, Fenghua Yang and Xiaofeng Zhang# (2020). Structure of the yeast Swi/Snf complex in a nucleosome-free state. Nature Communications
13. Fenghua Yang, Tong Bian, Xiechao Zhan, Zhe Chen, Zhihan Xing, Nicolas A. Larsen, Xiaofeng Zhang#, and Yigong Shi# (2023). Mechanisms of the RNA Helicases DDX42 and DDX46 in Human U2 snRNP Assembly. Nature Communications
完整列表见：
Google Scholar: https://scholar.google.com/citations?hl=en&user=wn-h3boAAAAJ
招生招聘:
实验室长期招聘生物化学、结构生物学、细胞生物学等相关背景的博士后和副研究员，待遇从优。同时热忱欢迎本科生前来攻读硕士、博士学位。
联系方式:
邮箱：xiaofengzhang@ustc.edu.cn