陈亮博士。中国科大生医部双聘特任研究员、附属第一医院研究员。中国科学院优秀博士论文获得者、安徽省学术和技术带头人后备人选、安徽省科学技术奖自然科学一等奖获得者（2/4）。中国科大生物化学与分子生物学博士，历任中国科大生医部博士后、特任副研究员。主要从事非编码RNA在重大疾病中调控细胞稳态的机制研究。获批并主持国家自然科学基金面上项目与青年项目、安徽省高校杰出青年科研项目、安徽省自然科学基金、国家博士后科学基金、校青年创新基金等项目，并作为课题骨干参与科技部国家重大研发计划。近年来以第一（共一）或通讯（共通）作者署名在Nature Communications (2)、Advanced Science (2)、PNAS、Trends in Biochemical Sciences、Genome Research、Oncogene (3)、Cell Death & Disease、Cancer Letters (3)、RNA Biology (3)、Science China Life Sciences等国际期刊发表论文，2篇入选ESI全球高被引论文，总引用超4000次。曾获中国科大生命科学学院第一届“杰出论文研究奖”。现任中国医师协会心血管内科医师分会心血管疾病精准检测学组委员、安徽省抗癌学会家族遗传性肿瘤分会常务委员、安徽省病理生理学会心血管分会常务委员；《Noncoding RNA Research》编委、《生命科学》青年编委等职。
主要研究兴趣：
1、非编码RNA生成、转运等基本RNA生物学进程的生理病理关联；
2、非编码RNA与RNA结合蛋白的互作的功能与机制
3、功能性非编码RNA在肿瘤（耐药）及心血管疾病（冠脉钙化）等人类重大疾病中调控稳态的机制
近年部分学术论文（第一/通讯）：
(1) Xiuzhi Li#, Xiaolin Wang#*, Xu Liu, Ge Shan*, Liang Chen*, A UFD1 variant encoding a microprotein modulates UFD1f and IPMK ubiquitination to play pivotal roles in anti-stress responses, Nature Communications, 2025;16(1):6695.
(2) Hanyuan Liu#, Chenchen Zhu#, Xuelin Yao, Yi Liu, Jing Zhu, Yuebo Li, Hanjie Xu, Cheng Peng*, Ge Shan*, Liang Chen*, Ying Zhou*, Ascites circRNA ASCOR drives platinum resistance of high-grade serous ovarian cancer by facilitating RPA1 nuclear translocation, Advanced Science, 2026:e18922.
(3) Yi Liu, Hanyuan Liu, Chenchen Zhu, Yan Yang, Zhen Shen, Ge Shan*, Liang Chen*, Ying Zhou*, Tumor exosome-transmitted lncRNA CATED promotes platinum-resistance in high-grade serous ovarian cancer, Advanced Science, 2025: e05963.
(4) Yinchun Zhong#, Yan Yang#, Xiaolin Wang, Bingbing Ren, Xueren Wang*, Ge Shan*, Liang Chen*, Systematic identification and characterization of Exon-intron circRNAs, Genome Research, 2024, 34(3):376-393.
(5) Hanyuan Liu, Sisi Deng, Xuelin Yao, Yi Liu, Lili Qian, Yingying Wang, Tianjiao Zhang, Ge Shan*, Liang Chen*, Ying Zhou*, Ascites exosomal lncRNA PLADE enhances platinum sensitivity by inducing R-loops in ovarian cancer, Oncogene, 2024, 43(10):714-728.
(6) Gui-Bin Gao#, Liang Chen#, Jia-Feng Pan, Tao Lei, Xin Cai, Zhexue Hao, Qi Wang, Ge Shan, Jin Li*, LncRNA RGMB-AS1 inhibits HMOX1 ubiquitination and NAA10 activation to induce ferroptosis in non-small cell lung cancer, Cancer Letters, 2024, 216826.
(7) Shuhui Chang#, Yucong Wang#, Xiaolin Wang, Hanyuan Liu, Tao Zhang, Yangge Zheng, Xueren Wang, Ge Shan*, Liang Chen*, HNRNPD regulates the biogenesis of circRNAs and the ratio of mRNAs to circRNAs for a set of genes, RNA Biology, 2024, 21(1):1-15.
(8) Xu Liu#, Xuelin Yao#, Liang Chen*, Expanding roles of circRNAs in cardiovascular disease, Non-coding RNA Research, 2024, 9(2):429-436
(9) Xuelin Yao#, Hanyuan Liu#, Zhen Wang, Fangting Lu, Wenying Chen, Qing Feng, Yahu Miao, Jie Zhang, Yanlei Wang, Ye Chen, Liping Xue, Yehai Liu, Liang Chen*, Qiu Zhang*, Circular RNA EIF3I promotes papillary thyroid cancer progression by interacting with AUF1 to increase Cyclin D1 production, Oncogene, 2023, 42(43):3206-3218.
(10) Liang Chen#; Yucong Wang#; Jiamei Lin; Zhenxing Song; Qinwei Wang; Wenfang Zhao; Yan Wang; Xiaoyu Xiu; Yuqi Deng; Xiuzhi Li; Qiqi Li; Xiaolin Wang; Jingxin Li; Xu Liu; Kunpeng Liu; Jincong Zhou; Kuan Li; Yuchan Liu; Shanhui Liao; Qin Deng; Chao Xu; Qianwen Sun; Shengzhou Wu; Kaiming Zhang; Min-Xin Guan; Tianhua Zhou; Fei Sun; Xiujun Cai; Chuan Huang*; Ge Shan*; Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs, Nature Communications, 2022, 13(1): 5769
(11) Liang Chen, Chuan Huang*, Ge Shan*; Circular RNAs in physiology and non-immunological diseases, Trends in Biochemical Sciences, 2022, 47(3): 250-264
(12) Pengcheng Liu#; Yucong Wang#; Ningning Zhang; Xiaomin Zhao; Renming Li; Yu Wang; Chen Chen; Dandan Wang; Xiaoming Zhang; Liang Chen*; Dahai Zhao*; Comprehensive identification of RNA transcripts and construction of RNA network in chronic obstructive pulmonary disease., Respiratory Research, 2022, 23(1): 154-154
(13) Liang Chen*, Ge Shan*, CircRNA in cancer: Fundamental mechanism and clinical potential, Cancer Letters, 2021,18;505:49-57.
(14) Ying Zhou#; Hanyuan Liu#; Juan Wang; Xiaolin Wang; Lili Qian; Fei Xu; Weiguo Song; Dabao Wu; Zhen Shen; Dingqing Feng; Bin Ling; Weihua Xiao; Ge Shan*; Liang Chen*; ΔNp63α exerts antitumor functions in cervical squamous cell carcinoma, Oncogene, 2019, 39: 905-921
(15) Liang Chen*, Emmanuel Enoch Dzakah, Ge Shan*, Targetable long non-coding RNAs in cancer treatments, Cancer Letters, 2018, 418, 119–124.
(16) Liang Chen, Farooq Rashid, Abdullah Shah, Hassaan M Awan, Mingming Wu, An Liu, Jun Wang, Tao Zhu, Zhaofeng Luo, Ge Shan*, The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation, Proceedings of National Academy of Sciences U S A (PNAS), 2015, 112(32):10002-10007.
(17) Liang Chen, Ge Shan*, Circular RNAs remain peculiarly unclear in biogenesis and function, Science China Life Sciences, 2015, 58(6):616-618.
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E-mail: anqingcl@ustc.edu.cn