博士，双聘特任研究员。中国科学院优秀博士论文获得者，安徽省自然科学一等奖获得者（2/4）。中国科学技术大学生物化学与分子生物学博士，博士后。主要从事非编码RNA在重大疾病中功能与功能机理、功能性RNA适配体方面的研究。出站后历任中国科大生医部基础医学院特任副研究员，2023年4月起双聘于中国科学技术大学生命科学与医学部和附属第一医院心血管病研究所工作。期间获得并主持国家自然科学基金面上项目与青年项目；安徽省自然科学基金、国家博士后科学基金、中国科大青年创新基金等项目，并作为课题骨干参与科技部国家重大研发计划。主要研究成果发表在Nature Communications、PNAS、Trends in Biochemical Sciences、Oncogene、Respiratory Research、Nature Structural & Molecular Biology等期刊，获中国科学技术大学生命科学学院第一届“杰出论文研究奖”。担任安徽省病理生理学会心血管分会常委、安徽省抗癌学会家族遗传性肿瘤分会常委。

主要研究兴趣：

1、非编码RNA在重大疾病中功能与功能机理

2、环状RNA生成、出核调控与生理病理

3、功能性RNA适配体筛选与医学转化

代表性学术论文（第一/通讯）：

1. Liang Chen^#, Yucong Wang^#, …, Chuan Huang^*, Ge Shan^*, Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs, Nature Communications, 2022, 13(1):5769.

2. Liang Chen, Chuan Huang^*, Ge Shan^*, Circular RNAs in physiology and non-immunological diseases, Trends in Biochemical Sciences, 2021, 47(3):250-264.

3. Liang Chen, Farooq Rashid, Abdullah Shah, Hassaan M Awan, Mingming Wu, An Liu, Jun Wang, Tao Zhu, Zhaofeng Luo, Ge Shan^*，The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation，Proceedings of National Academy of Sciences U S A, 2015, 112(32):10002-10007.

4. PengCheng Liu^#, Yucong Wang^#, Ningning Zhang, Xiaomin Zhao, Renming Li, Yu Wang, Chen Chen, Dandan Wang, Xiaoming Zhang, Liang Chen^*, Dahai Zhao^*, Comprehensive identification of RNA transcripts and construction of RNA network in chronic obstructive pulmonary disease, Respiratory Research, 2022, 23(1):154.

5. Sisi Deng, Lili Qian, Luwen Liu, Hanyuan Liu, Zhihao Xu, Yujie Liu, Yingying Wang, Liang Chen^*, Ying Zhou^*. Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1. Cancer Science. 2023, 114(4):1582-1595.

6. Liang Chen^*, Ge Shan^*, CircRNA in cancer: Fundamental mechanism and clinical potential, Cancer Letters, 2021,18;505:49-57.

7. Hanyuan Liu^# , Chenchen Zhu^# , Zhihao Xu, Juan Wang, Lili Qian, Qingqing Zhou, Zhen Shen, Weidong Zhao, Weihua Xiao, Liang Chen^*, Ying Zhou^*, lncRNA PART1 and MIR17HG as ΔNp63α direct targets regulate tumor progression of cervical squamous cell carcinoma, Cancer Science, 2020, 111(11):4129-4141.

8. Ying Zhou^#, Hanyuan Liu^#, Juan Wang, Xiaolin Wang, Lili Qian, Fei Xu, Weiguo. Song, Dabao Wu, Zhen Shen, Dingqing Feng, Bing Ling, Weihua Xiao, Ge Shan^*, Liang Chen^*. DeltaNp63alpha exerts antitumor functions in cervical squamous cell carcinoma. Oncogene 2019, 39(4):905-921.

9. Liang Chen^*, Emmanuel Enoch Dzakah, Ge Shan^*, Targetable long non-coding RNAs in cancer treatments, Cancer Letters, 2018, 418, 119–124.

10. Hassaan M Awan^#, Abdullah Shah^# , Farooq Rashid^#, Shuai Wei, Liang Chen^*, Ge Shan^*, Comparing two approaches of miR-34a target identification, biotinylated-miRNA pulldown vs miRNA overexpression. RNA Biology, 2018(15): 55-61.

联系方式：

办公室：0551-63601356

E-mail: anqingcl@ustc.edu.cn