主要研究方向：
人类重大疾病相关膜蛋白，尤其是ABC专业蛋白的结构和功能研究。
代表性论文：
（#, co-first author; *, corresponding author）
(1) Wang, Liang#; Hou, Wen-Tao#; Chen, Li; Jiang, Yong-Liang; Xu, Da; Sun, Linfeng*; Zhou, CongZhao*; Chen, Yuxing*; Cryo-EM structure of human bile salts exporter ABCB11, Cell Research, 2020, 30(7): 623-625
(2) Wang, Liang#; Hou, Wen-Tao#, *; Wang, Jie; Xu, Da; Guo, Cong; Sun, Linfeng; Ruan, Ke; Zhou, Cong-Zhao*; Chen, Yuxing*; Structures of human bile acid exporter ABCB11 reveal a transport mechanism facilitated by two tandem substratebinding pockets, Cell Research, 2022, 0: 1-4
(3) Meng-Ting Cheng#; Yu Chen#; Zhi-Peng Chen; Xin Liu; Zhiyong Zhang; Yuxing Chen*; Wen-Tao Hou*; Cong-Zhao Zhou*; Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding, Proceedings of the National Academy of Sciences, 2022,119(14)
(4) Wen‐Tao Hou; Da Xu; Liang Wang; Yu Chen; Zhi‐Peng Chen; Cong‐Zhao Zhou*; Yuxing Chen*; Plastic structures for diverse substrates: A revisit of human ABC transporters, Proteins: Structure, Function, and Bioinformatics, 2022, 9(10): 1749-1765
(5) Zhi-Peng Chen; Da Xu; Liang Wang; Yao-Xu Mao; Yang Li; Meng-Ting Cheng; Cong-Zhao Zhou*; Wen-Tao Hou*; Yuxing Chen*; Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1, Nature Communications, 2022, 13(1)
(6) Yang, Hong-Bo#; Hou, Wen-Tao#; Cheng, Meng-Ting#; Jiang, Yong-Liang*; Chen, Yuxing*; Zhou, Cong-Zhao*; Structure of a MacAB-like efflux pump from Streptococcus pneumoniae, Nature Communications, 2018, 9(1): 196-196
(7) Cao, Dong Dong#; Zhang, Chun Peng#; Zhou, Kang; Jiang, Yong Liang; Tan, Xiao Feng; Xie, Jin; Ren, Yan Min; Chen, Yuxing; Zhou, Cong Zhao*; Hou, Wen-Tao*; Structural insights into the catalysis and substrate specificity of cyanobacterial aspartate racemase McyF, Biochemical and Biophysical Research Communications, 2019, 514(4): 1108-1114
(8) Chen, Li#; Hou, Wen-Tao#; Fan, Tao; Liu, Banghui; Pan, Ting; Li, Yu-Hui; Jiang, Yong-Liang; Wen, Wen; Chen, Zhi-Peng; Sun, Linfeng*; Zhou, Cong-Zhao*; Chen, Yuxing*; Cryo-electron Microscopy Structure and Transport Mechanism of a Wall Teichoic Acid ABC Transporter, mBio, 2020, 11(2)
(9) Guo, Cong#; Feng, Zhang#; Zuo, Gang; Jiang, Yong-Liang; Zhou, Cong-Zhao; Chen, Yuxing*; Hou, Wen-Tao*; Structural and functional insights into the Asp1/2/3 complex mediated secretion of pneumococcal serine-rich repeat protein PsrP, Biochemical and Biophysical Research Communications, 2020, 524(3): 784-790
(10) Xin Wang#; Meng-Ting Cheng#; Zhi-Peng Chen; Yong-Liang Jiang; Yu-Shu Ge; Rong Xia*; Wen-Tao Hou*; Structural and biochemical analyses of the tetrameric carboxypeptidase S9Cfn from Fusobacterium nucleatum, Acta Crystallographica Section D Structural Biology, 2021, (77): 1554-1563
(11) Xu, Da; Li, Yanyan; Yang, Fengrui; Sun, Cai-Rong; Pan, Jinheng; Wang, Liang; Chen, ZhiPeng; Fang, Shu-Cheng; Yao, Xuebiao; Hou, Wen-Tao*; Zhou, Cong-Zhao*; Chen, Yuxing*; Structure and transport mechanism of the human cholesterol transporter ABCG1, Cell Reports, 2022, 38:110298