石攀

石攀

2022-09-12来源：生命科学与医学部




中国科学技术大学副教授，博士毕业于中国科学技术大学。长期从事重要疾病相关药物靶标蛋白的动态特性研究，主要研究方向是发展非天然氨基酸标记和生物物理方法研究重要疾病相关靶标蛋白的动态功能机制。在Cell Research，National Science Reviews，Cell Discovery,  Angewandte Chemie International Edition等杂志发表30余篇研究论文，主持国家自然科学基金青年项目和面上项目多项，参与国家重点研发计划等项目，获得安徽省杰出青年基金项目（2021）资助。

联系方式：shipan@ustc.edu.cn。


主要研究方向：

（1）神经系统疾病、肿瘤等重大疾病相关膜蛋白的动态构象机制研究

（2）发展19F核磁共振方法研究大分子量蛋白质动态特性以及重要疾病相关蛋白的创新型药物设计和筛选


近五年代表性论著：

  1. Bo Q#, Zhang MG#, Yang F#, Zheng Y, Li ZL, Zheng YM, Wu FM, Liang J, Zhou L, Li DS, Wu Y, Tian C*, Lv P*, Shi P*. Somatostatin receptor 2 targeting peptide modifications for peptide-drug conjugate treatment of small cell lung cancer. Acta Pharmacol Sin. 2025. 0:1–11；doi: 10.1038/s41401-025-01584-w.

  2. Li Z#, Zhang Y#, Liang J#, Jia F, Song J, Sun D, Shi C*, Tian C*, Shi P*. Solution NMR Analysis Reveals Synergistic β-Arrestin1 Activation by Chemically Synthesized Phosphopeptides of a C-Terminal Tail and ICL3 of NTSR1. ACS Chem Biol.2025. 20(7):1464-1469.

  3. Zhang Y#, Zhu Y#, Zhang Y#, Shi C, Zhang L, Liang J*, Tian C*, Shi P*. 19F NMR chemical shift encoded peptide screening targeting the potassium channel Kv1.3. Chemical Communications. 2025;61(33):6162-6165.

  4. Ling S#*, Meng X#, Zhang Y#, Xia Z, Zhou Y, Yang F, Shi P*, Shi C*, Tian C*. Structural insights into asymmetric activation of the calcium-sensing receptor-Gq complex. Cell Research.2024;34(2):169-172.

  5. Li YG, Meng XY, Yang X, Ling SL, Shi P*, Tian CL*, Yang F*. Structural insights into somatostatin receptor 5 bound with cyclic peptides. Acta Pharmacol Sin. 2024 (11):2432-2440.

  6. Zhao R#, Shi P#, Cui JB#, Shi C*, Wei XX, Luo J, Xia Z, Shi WW, Zhou Y, Tang J, Tian C, Meininghaus M, Bierer D, Shi J*, Li YM*, Liu L*. Single-Shot Solid-Phase Synthesis of Full-Length H2 Relaxin Disulfide Surrogates. Angew Chem Int Ed Engl. 2023;62(6):e202216365

  7. Sun W#, Yang F#, Zhang H#, Yuan Q#, Ling S, Wang Y, Lv P, Li Z, Luo Y, Liu D, Yin W*, Shi P*, Xu HE*, Tian C*. Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists. Cell Discovery.2023 ;9(1):66.

  8. Yang F#, Zhang H#, Meng X#, Li Y, Zhou Y, Ling S, Sun D, Lv P, Liu L*, Shi P*, Tian C*. Structural insights into thyrotropin-releasing hormone receptor activation by an endogenous peptide agonist or its orally administered analogue. Cell Research.2022; 32(9):858-861.

  9. Fang W#, Yang F#, Xu C#, Ling S#, Lin L, Zhou Y, Sun W, Wang X, Liu P, Rondard P,Shi P*, Pin JP*, Tian C*, Liu J*. Structural basis of the activation of metabotropic glutamate receptor 3, Cell Research, 2022;32(7):695-698.

  10. Sun W#, Yuan Q#, Zhang H#, Yang F, Ling S, Luo Y, Lv P, Eric Xu H*, Tian C*, Yin W*, Shi P*. Structural insights into the activation of neurokinin 2 receptor by neurokinin A. Cell Discovery. 2022;8(1):72.

  11. Bo Q#, Yang F#, Li Y#, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L*, Shi P*, Tian C*. Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues. Cell Discovery. 2022;8(1):47. doi: 10.1038/s41421-022-00405-2.

  12. Li L, Zhang J, Sun W, Gong W, Tian C,Shi P∗, Shi C*, Allosteric conformational changes of G proteins upon its interaction with membrane and GPCR, Chinese Chemical Letters 2022, 33, 747–750.

  13. Ling S#, Shi P#, Liu S#, Meng X#, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D*, Liu L*, Tian C*. Structural Mechanism of the Human Calcium-Sensing Receptor Cooperatively Activated by Ca2+ Ions and L-tryptophan. Cell Research. 2021, 31, 383–394.

  14. Yang F#, Ling S#, Zhou Y#, Zhang Y, Lv P, Liu S, Fang W, Sun W, Hu LA, Zhang L, Shi P*, Tian C*. Different Conformational Responses of the b2-Adrenergic Receptor-Gs Complex upon Binding of the Partial Agonist Salbutamol or the Full Agonist Isoprenaline. National Science Review. 2020. 8(9)

  15. Zhang Y#, Yang F#, Ling S#, Lv P, Zhou Y, Fang W, Sun W, Zhang L, Shi P*, Tian C*. Single-particle cryo-EM structural studies of the β2AR-Gs complex bound with a full agonist formoterol. Cell Discovery. 2020; 6:45.

  16. Shi P#*, Zhang Y#, Lv P#, Fang W, Ling S, Guo X, Li D, Liu S, Sun D, Zhang L, Liu D, Zheng JS, Tian C*. A genetically encoded small-size fluorescent pair reveals allosteric conformational changes of G proteins upon its interaction with GPCRs by fluorescence lifetime based FRET, Chemical Communications. 2020, 56(51):6941-6944.

  17. Zhao R#, Shi P#, Chen J#, Sun S, Chen J, Cui J, Wu F, Fang G, Tian C, Shi J*, Bierer D, Liu L*, Li YM*. Chemical synthesis and biological activity of peptides incorporating an ether bridge as a surrogate for a disulfide bond, Chemical Science, 2020, 11, 7927–7932.