姚雪彪

姚雪彪

2022-05-31来源:生命科学学院



博士,教授。国家自然科学基金委“杰出青年基金”获得者,国家自然科学基金委“着丝粒动态组装与调控”创新群体负责人(2017-2022),细胞动力学教育部重点实验室主任(2019-至今)。


1995年美国加州大学伯克利分校获细胞分子生物学博士学位,1997年受聘为美国威斯康星州医学院生理系助理教授。1999年入选“国家自然科学杰出青年基金”、教育部“长江学者”,2000年任中国科学技术大学教授,组建细胞动力学教育部重点实验室,现为细胞动力学教育部重点实验室主任。作为项目首席科学家主持了973 项目“调控细胞增殖重要蛋白质作用网络的研究”,国家重点研发计划项目“着丝粒蛋白质机器调控细胞命运抉择的分子机制”,基金委重大项目“染色体蛋白质机器组装的相分离与相变机制研究”。获美国Giannini学者奖、GCC Distinguished Scientist Award、ACS Research Scholar Award等,2021年入选美国胃肠医学会会士。曾/并担任国际期刊J Biol ChemCell DiscoveryCell Research编委,J Mol Cell BiolBMC Cell Biology副主编。兼任美国细胞生物学会国际事务部主任,美国Keystone Symposia Scientific Advisory Board委员,中国细胞生物学会外事委员会主任、中国细胞生物学会细胞结构与行为分会会长。


围绕细胞增殖命运抉择的时空动力学分子机制,姚雪彪和他的科研团队联合应用比较基因组学、时空蛋白质组学与生物光子学方法,揭示了细胞分裂调控蛋白质机器着丝粒赖氨酸动态修饰的时空调控规律,阐明了调控染色体可塑性的丝氨酸-赖氨酸修饰动态交流机制,发现了后生代细胞分裂调控通路的新效应分子与相分离调控染色体可塑性新模式。其研究工作发表在Cell、Nature、Nat Cell Biol、Annual Reviews等顶级学术期刊,作为通讯作者在Cancer CellNat Rev Mol Cell Biol、Nat Chem Biol、GastroenterologyCell ResearchPNASNat CommunCancer Research等国际学术期刊发表论文150 余篇。培养博士毕业生74名,其中包括基金委“优青”、中组部“万人”计划入选者;吴瑞奖、教育部“青年长江”、“中科院优秀博士论文”获得者;另有7名学生以“青千”回国,成为独立实验室PI。

 

主要研究方向:

1. 着丝粒动力学与类器官可塑性 

2. 无膜细胞器与生物力学 

 

近期代表性学术论文:

1. Song X#, Yang F#, Liu X#, Xia P#, Yin W, Wang Z, Wang Y, Yuan X, Dou Z, Jiang K, Ma M, Hu B, Zhang R, Xu C, Zhang Z, Ruan K, Tian R, Li L, Liu T, Hill DL, Zang J*, Liu X*, Li J*, Cheng J*, Yao X*. Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis. Nat Chem Biol. 17(12):1314-1323. (2021) (Highlighted by Nature Chemical Biology)

2. Xu L#, Ali M#, Duan W#, Yuan X*, Garba F, Mullen M, Sun B, Poser I, Duan H, Lu J, Tian R, Ge Y, Chu L, Pan W, Wang D, Hyman A, Green H, Li L, Dou Z*, Liu D*, Liu X*, Yao X*. Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation. Cell Rep. 36(2):109343. (2021)

3. Huang Y#, Lu J#, Zhan L, Wang M, Shi R, Yuan X, Gao X, Liu X, Zang J, Liu W, Yao X*. Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism. J Biol Chem. 2021 Aug;297(2):100929. doi: 10.1016/j.jbc.2021.100929. Epub 2021 Jul 1. PMID: 34216621

4. Liu X, Liu X, Wang H, Dou Z, Ruan K, Hill DL, Li L, Shi Y, Yao X*. Phase separation drives decision making in cell division. J Biol Chem. 295(39):13419-13431. (2020) Review. (Recommended by F1000)

5. Huang Y#, Lin L#, Liu X#, Ye S#, Yao PY, Wang W, Yang F, Gao X, Li J, Zhang Y, Zhang J, Yang Z, Liu X, Yang Z, Zang J, Teng M, Wang Z, Ruan K, Ding X, Li L, Cleveland DW, Zhang R*, Yao X*. BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules. Cell Res. 29(7):562-578. (2019) (Highlighted by Cell Research)

6. Yu H, Yang F, Dong P, Liao S, Liu WR, Zhao G, Qin B, Dou Z, Liu Z, Liu W, Zang J, Lippincott-Schwartz J, Liu X, Yao X*. NDP52 tunes cortical actin interaction with astral microtubules for accurate spindle orientation. Cell Res. 29(8):666-679. (2019)

7. Yao X*, Smolka AJ. Gastric parietal cell physiology and Helicobacter pylori-induced disease. Gastroenterology. 156(8):2158-2173. (2019)

8. Mo F#, Zhuang X#, Liu X*, Yao PY, Qin B, Su Z, Zang J, Wang Z, Zhang J, Dou Z, Tian C, Teng M, Niu L, Hill DL, Fang G, Ding X, Fu C, Yao X*. Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation. Nat Chem Biol. 12(4):226-32. (2016) (Highlighted by Nature Chemical Biology)

9. Dou Z#, Liu X#, Wang W, Zhu T, Wang X, Xu L, Abrieu A, Fu C, Hill DL, Yao X*. Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachment. Proc Natl Acad Sci U S A. 112(33):E4546-55. (2015)

10. Zhao X#, Wang D#, Liu X, Liu L, Song Z, Zhu T, Adams G, Gao X, Tian R, Huang Y, Chen R, Wang F, Liu D, Yu X, Chen Y, Chen Z, Teng M, Ding X, Yao X*. Phosphorylation of the Bin, Amphiphysin, and RSV161/167 (BAR) domain of ACAP4 regulates membrane tubulation. Proc Natl Acad Sci U S A. 110(27):11023-8. (2013)

11. Yao X*, Li D, Pei G*. In focus: molecular and cell biology research in China. Nat Rev Mol Cell Biol. 14(9):600-6. (2013)

12. Xia P#, Wang Z#, Liu X, Wu B, Wang J, Ward T, Zhang L, Ding X, Gibbons G, Shi Y, Yao X*. EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis. Proc Natl Acad Sci U S A. 109(41):16564-9. (2012) (Recommended by F1000)

13. Tao Y, Jin C, Li X, Qi S, Chu L, Niu L, Yao X*, Teng M*. The structure of the FANCM-MHF complex reveals physical features for functional assembly. Nat Commun. 3:782. (2012)

14. Chen J#, Yao Y#, Gong C#, Yu F#, Su S, Chen J, Liu B, Deng H, Wang F, Lin L, Yao H, Su F, Anderson KS, Liu Q, Ewen ME, Yao X*, Song E*. CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell. 19(4):541-55. (2011) (Recommended by F1000)

15. Ding X#, Yan F#, Yao P, Yang Z, Wan W, Wang X, Liu J, Gao X, Abrieu A, Zhu T, Zhang J, Dou Z, Yao X*. Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin. Cell Res. 20(12):1386-9. (2010)

 

联系方式:

电话:0551-63607141;邮箱: yaoxb@ustc.edu.cn

实验室网页:http://lcd.ustc.edu.cn/

ResearcherID: http://www.researcherid.com/rid/P-5771-2014

 


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