朱书

朱书

2021-02-01来源:生命科学与医学部


研究方向:

机体免疫系统如何识别自我非我的抗原是免疫学的核心问题。机体发展了针对自我抗原的中枢耐受机制避免免疫系统攻击自身抗原(1960年诺贝尔生理与医学奖)。针对非我抗原,免疫系统已经发展出感知病原信号并启动免疫激活和清除机制的系统(2011年诺贝尔生理与医学奖)。肠道是人体极为特殊也是最大的粘膜免疫器官,聚集了全身一半以上的免疫细胞,来应对大量偶发性的病原细菌病毒感染,以及持续存在的共生微生物和食物抗原等。其中,共生微生物、食物等非我共生物质如何被识别并启动免疫稳态或者耐受的生理机制,以及该过程失调导致的疾病机制还有诸多未知。我们课题组在肠道免疫识别方向近几年以通讯作者发表了一系列工作:

1.解析肠道上皮细胞特异表达受体NLRP6感知肠道病毒来源的dsRNA并形成相分离高效整合IL-18/IFN等信号维持免疫稳态的机制(Cell 2021;Science Advance 2023;PNAS 2024);

2.发现肠道上皮细胞NLR下游效应分子GSDMD响应食物抗原刺激剪切入核转录MHCII从而诱导Tr1介导的免疫耐受(Cell 2023),并发现缺乏大分子蛋白质的氨基酸食物长期喂食会导致肠道微生物紊乱以及抑郁样行为Cell Reports 2024)。

3.鉴定肠道上皮细胞及免疫细胞多个受体(PMCA,AHR,ADRA2A)感知共生微生物异常产生的代谢产物小分子(DCA,IDA,Tyramine)抑制正常生理过程(CTL killing,IEC ferroptosis,ISC proliferation)促进肠癌或肠炎发病的机制(Immunity 2024;Nature Cell Biology 2024;Cell Host Microbe 2024);并开发不破坏肠道微生物的抗生素递送新方法(Nature Biomedical Engineering 2022) 。

实验室将进一步围绕肠道微环境中免疫系统、微生物、食物之间的互作展开研究及临床应用工作。


个人简介:

基础医学院执行院长,生命科学与医学部副部长。国家杰青。曾获中组部创新人才计划,基金委优青、MIT 35 Innovators under 35 China,求是杰出青年学者奖,中源协和创新突破奖等。研究方向为肠道微生物的免疫识别和免疫调控,以及微生物及免疫新疗法。发表文章70余篇,近5年以通讯作者在Cell(2023,2021),Immunity(2024),Nature Biomedical Engineering(2022),Cell Research (2023),PNAS (2024,2021),Science Advance (2023),Cell Reports (2024,2022),Nature Reviews Gastroenterology & Hepatology(2022)等杂志发表研究和综述论文。总引用8000余次,H index 39。Nature、Cell、Immunity、Lancet、PNAS、Gut等杂志审稿人。以第一发明人申请国家发明专利28项,PCT专利7项,获批发明专利7项,3个项目已获得批件进入研究者发起的临床试验阶段。

 

实验室网页http://zhulab.ustc.edu.cn/

联系方式:zhushu@ustc.edu.cn 

电话:0551-63600317

OCRID ID: 0000-0002-8163-0869


教育和研究经历:

2002-2006年,中国科学技术大学生命科学学院,获学士学位

2006-2012年,上海生命科学研究院健康科学研究所,获细胞生物学博士学位

2012-2017年,美国耶鲁大学医学院免疫学系,博士后

2017年  至今,中国科学技术大学生命科学与医学部,教授博导

 

获奖情况: 

2006年  郭沫若奖学金

2011年  中科院院长优秀奖

2011年  强生亚洲优秀研究生论文奖

2012年  中科院院长特别奖

2012年  吴瑞奖学金

2012年  中科院百篇优博论文

2014年  Helen-Hay Whitney-HHMI Fellowship

2017年  中组部创新人才计划

2018年  MIT Technology Review 35 Innovators Under 35(MIT TR35 China)

2018年  求是杰出青年学者

2018年  基金委优青

2022年  中源协和创新突破奖

2023年  基金委杰青

 

发表论文:(*第一作者,#通迅作者)

2024

72. Cong J*, Liu P*, Han Z*, Ying W, Li C, Yang J, Song X, Dai L, Sun L, Kasper D, Pan W#, Zhu S#. Bile acids modified by the microbiota suppress gut anti-tumor immune responses. Immunity. 2024 Mar 6:S1074-7613(24)00090-6. doi: 10.1016/j.immuni.2024.02.014. (IF=43.5)

Preview in:

mmunity.doi: 10.1016/j.immuni.2024.03.006. Hostile bile limits anti-cancer immunity.

71. Li C, Zhang P, Xie Y, Wang S, Guo M, Wei X, Zhang K, Cao D, Zhou R, Wang S, Song X#, Zhu S#, Pan W#. Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis. Cell Host Microbe. 2024 May 21:S1931-3128(24)00140-9. doi: 10.1016/j.chom.2024.04.020. (IF=30.1)

70. Zhu S#, Pan W#. Microbial metabolite steers intestinal stem cell fate under stress. Cell Stem Cell. doi.org/10.1016/j.stem.2024.04.006. (IF=23.9)

69. Ren X, Liu Q, Zhou P, Zhou T, Wang D, Mei Q, Flavell RA, Liu Z#, Li M#, Pan W#, Zhu S#. DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells. Nature Communications. 2024 Apr 9;15(1):3080. doi: 10.1038/s41467-024-47235-2. (IF=16.6)

68. Hu J*, He K*, Yang Y*, Huang C, Dou Y, Wang H, Zhang G, Wang J, Niu C, Bi G, Zhang L#, Zhu S#. Amino-acid formula induces microbiota dysbiosis and contributes to depressive-like behavior. Cell Reports. 2024 Feb 26;43(3):113817.doi: 10.1016/j.celrep.2024.113817. (IF=10.0)

67. Li R*, Zan Y*, Wang D, Chen X, Wang A, Tan H, Zhang G, Ding S, Shen C#, Wu H#, Zhu S#. A mouse model to distinguish NLRP6-mediated inflammasome-dependent and independent functions. PNAS. 2024 Feb 6;121(6):e2321419121. doi: 10.1073/pnas.2321419121. (IF=11.1)

66. W Cui, M Guo, D Liu, Y Zhang, J Cong, Z Han, Y Yang, J Liu, C Liang, S Shi, P Xiao, C Yang, H Huang, X Fu, Y Xu, L Du, C Yin, Y Zhang, J Sun, R Chai#, W Gu#, S Zhu#, B Chu#. Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition. Nature Cell Biology. 26, 124–137 (2024). (IF=28.2)

 

2023

65. K He*, T Wan*, D Wang*, J Hu*, T Zhou, W Tao, Z Wei, Q Lu, R Zhou, Z Tian, R Flavell#, and S Zhu#. Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine. Cell. 2023 Jun 9;S0092-8674(23)00577-9. doi: 10.1016/j.cell.2023.05.027. (IF=66.9)

Comment in:

Trends in Immunology. 2023 Aug;44(8):571-573. doi: 10.1016/j.it.2023.06.006. Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens.

Cell Research. 2023 Dec;33(12):896-897. doi: 10.1038/s41422-023-00856-6. Cleaving an epithelial path to food tolerance.

Gastroenterology. doi:10.1053/j.gastro.2023.08.024. Tolerance to Dietary Antigens in the Upper Intestine Through Chopping of Gasdermin D.

Allergy. doi: 10.1111/all.16076. Insights in intestinal immune tolerance: The role of the cleavage form of gasdermin D.

64. T Wan*, Y Wang*, K He*, S Zhu#. Microbial sensing in the intestine. Protein & Cell, pwad028, 2023. doi.org/10.1093/procel/pwad028. (IF=15.3)

63. H Ma*, T Hu*, W Tao, J Tong, Z Han, D Herndler-Brandstetter, Z Wei, X Xu, K Zhang, R Liu, T Zhou, Q Liu, J Cho, HB Li#, H Huang#, R Flavell#, and Zhu S#. A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis. Cell Research. 2023, doi.org/10.1038/s41422-023-00790-7. (IF=46.3)

62. X Ren, D Wang, G Zhang, T Zhou, Z Wei, Y Yang, Y Zheng, X Lei, W Tao, A Wang, M Li#, R Flavell#,Zhu S#. Nucleic DHX9 Cooperates with STAT1 to Transcribe Interferon-Stimulated Genes. Science Advance. 2023, DOI: 10.1126/sciadv.add5005 (IF=14.1)

61. X Wang*, C Chen*, H Sun*, K Mao*, J Yao, W Zhang, M Zhan, H-B Li, Z Zhang#, S Zhu#, L Lu#. m6A mRNA modification potentiates Th17 functions to inflame autoimmunity. Sci. China Life Sci. (2023). https://doi.org/10.1007/s11427-022-2323-4. (IF=10.4)

60. Liu Z, Liu R, Gao H, Jung S, Gao X, Sun R, Liu X, Kim Y, Lee HS, Kawai Y, Nagasaki M, Umeno J, Tokunaga K, Kinouchi Y, Masamune A, Shi W, Shen C, Guo Z, Yuan K; FinnGen; International Inflammatory Bowel Disease Genetics Consortium; Chinese Inflammatory Bowel Disease Genetics Consortium; Zhu S, Li D, Liu J, Ge T, Cho J, Daly MJ, McGovern DPB, Ye BD, Song K, Kakuta Y, Li M, Huang H. Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries. Nature Genetics. 2023 May;55(5):796-806. doi: 10.1038/s41588-023-01384-0. Epub 2023 May 8. PMID: 37156999; PMCID: PMC10290755. (IF=30.8)

59. Wang J, Zhao D, Lei Z, P Ge, Z Lu, Q Chai, Y Zhang, L Qiang, Y Yu, X Zhang, B Li, S Zhu, L Zhang#, C Liu#. TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal. Cell Mol Immunol 20, 158–174 (2023). https://doi.org/10.1038/s41423-022-00963-1. (IF=24.1)

 

2022

58. Zhang G*, Wang Q*, Tao W*, Jiang W, Elinav E, Wang Y#, Zhu S#. Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis. Nature Biomedical Engineering. 2022 Jul;6(7):867-881. doi: 10.1038/s41551-022-00903-4. (IF=29.2)

57. Chen C*, W Zhang*, T Zhou, Q Liu, C Han, Z Huang, S Chen, Q Mei, C Zhang, K Zhang, H Ma, R Zhou, W Jiang, Wen Pan, Zhu S#. Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation. Cell Reports. 2022 Nov 29;41(9):111741. doi: 10.1016/j.celrep.2022.111741. (IF=10.0)

56. A Wang, W Tao, J Tong, J Gao, J Wang, G Hou, C Qian, G Zhang,R Li, D Wang, X Ren, K Zhang, S Ding, R Flavell, HB Li, W Pan#, S Zhu#.m6A modifications regulate intestinal immunity and rotavirus infection. Elife. 2022;11:e73628 DOI: https://doi.org/10.7554/eLife.73628 (IF=8.1)

55. Y Chen, X Wang, X Hao, B Li, W Tao, S Zhu, K Qu, H Wei, R Sun, H Peng, Z Tian. Ly49E separates liver ILC1s into embryo-derived and postnatal subsets with different functions. J Exp Med. 2022, 219(5): e20211805. (IF=17.58)

 

2021

54. Shen C*, Li R*, Negro R, Cheng J, Vora SM, Fu TM, Wang A, He K, Andreeva L, Gao P, Tian Z, Flavell RA, Zhu S#, Wu H#. Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome. Cell. 2021 Oct 14:S0092-8674(21)01115-6. doi:10.1016/j.cell.2021.09.032. (IF=41.6)

Comment in:

Cell Research. doi: 10.1038/s41422-021-00594-7. It’s just a phase: NLRP6 phase separations drive signaling.

53. M Guo*, W Tao*, R Flavell#, and S Zhu#. Potential intestinal infection and fecal–oral transmission of SARS-CoV-2. Nature Reviews Gastroenterology & Hepatology. 10.1038/s41575-021-00416-6 (IF=46.8)

52. Y Wang*, K He*, B Sheng*, X Lei, W Tao, X Zhu, Z Wei, R Fu, A Wang, S Bai, Z Zhang, N Hong, C Ye, Y Tian, J Wang, K Zhang, H Yang, L Li#, H Li#, R Flavell#, S Zhu#. The RNA helicase Dhx15 mediates Wnt-induced anti-microbial protein expression in Paneth cells. PNAS. 2021, 10.1073/pnas.2017432118 (IF=11.2)

51. Z Zhang*, G Zhang*, M Guo*, W Tao*, X Liu, H Wei, T Jin#, Y Zhang#, S Zhu#. The Potential Role of an Aberrant Mucosal Immune Response to SARS-CoV-2 in the Pathogenesis of IgA Nephropathy. Pathogens. 2021, 10(7), 881. doi: 10.3390/pathogens10070881(IF=3.5)

50. J Tong, X Wang, Y Liu, X Ren, A Wang, Z Chen, J Yao, K Mao, T Liu, F Meng, W Pan, Q Zou, J Liu, Y Zhou, Q Xia#, R Flavell#, S Zhu#, HB Li#. Pooled CRISPR Screening Identifies m6A as a Positive Regulator of Macrophage Activation. Science Advance. 10.1126/sciadv.abd4742 (IF=14.1)

49. Y Chen, S Zhao, J Hu, C Han, X Lv, G Wang, S Wang, P Bo, J Zhang, W Wu, W Gui, Q Tang#, Q Liu#, S Zhu#, F Yu#. Increased accumulation of α-Synuclein in inflamed appendix of Parkinson’s disease patients. Movement Disorders. 2021 Apr 20. doi: 10.1002/mds.28553 (IF=10.3)

48. X Zheng, L Liu, G Meng, S Zhu, R Zhou#, W Jiang#.IL-18 maintains the homeostasis of mucosal immune system via inflammasome-independent but microbiota-dependent manner. Science Bulletin. Doi: 10.1016/j.scib.2021.01.025 (IF=11.8)

47. Song H, Song J, Cheng M, Zheng M, Wang T, Tian S, Flavell RA, Zhu S, Li HB, Ding C, Wei H, Sun R, Peng H, Tian Z. METTL3-mediated m6A RNA methylation promotes the anti-tumor immunity of natural killer cells. Nat Commun. 2021 Sep 17;12(1):5522. doi: 10.1038/s41467-021-25803-0. (IF=14.9)

46. G Xu, C Liu, S Zhou, Q Li, Y Feng, P Sun, H Feng, Y Gao, J Zhu, X Luo, Q Zhan, S Liu, S Zhu, H Deng, D Li, P Gao. Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion. Molecular Cell. doi.org/10.1016/j.molcel.2021.05.002 (IF=18.0)

45. H Han, Y Cao, C Feng, Y Zheng, S Zhu, C Shang, C Yuan, G Zong. Association of a Healthy Lifestyle with All-Cause and Cause-Specific Mortality Among Individuals with Type 2 Diabetes: A Prospective Study in UK Biobank Short Running. Diabetes Care. doi.org/10.2337/dc21-1512 (IF=19.1)


2020

44. W Tao*, X Wang*, G Zhang*, M Guo, H Ma, D Zhao, L Liu, K Zhang, J Weng, Y Wang, X Ma#, T Jin# and S Zhu#. Re-detectable positive SARS-CoV-2 RNA tests in patients who recovered from COVID-19 with intestinal infection.Protein & Cell. 10.1007/s13238-020-00778-8 (IF=10.2)

43. R Li, S Zhu#. 2019. NLRP6 Inflammasome. Mol Aspect Med. doi.org/10.1016/j.mam.2020.

100859 (IF=9.6)

42. W Tao*, G Zhang*, X Wang*, X Ma, T Jin, L Liu#, J Weng#, and S Zhu#. Analysis of the intestinal microbiota in COVID-19 patients and its correlation with the inflammatory factor IL-18. Medicine in Microecology. 10.1016/j.medmic.2020.100023

41. W Wen*, G Zhang*, S Luo*, Z Bai, W Tao, M Guo, S Jia, W Liu, K Zhang, J Weng#, S Zhu#. Next-generation sequencing revealed influenza and Chlamydia infection in recurrent pneumonia in a recovered COVID-19 patient. Precision Clinical Medicine. 10.1093/pcmedi/pbaa033

40. L Yang*, T Geng*, G Yang*, J Ma, L Wang, H Ketkhar, D Yang, T Lin, J Hwang, S Zhu, Y Wang, J Dai, F You, G Cheng, A Vella, R Flavell#, E Fikrig#, P Wang#. Macrophage scavenger receptor 1 controls Chikungunya virus 2 infection through autophagy in mice. Communications Biology. 3, 556. https://doi.org/10.1038/s42003-020-01285-6 (IF=4.2)

 

2019

39. L Liu*, T Gong*, W Tao*, B Lin, C Li, X Zheng, S Zhu#, W Jiang#, R Zhou#. 2019. Commensal viruses maintain the homeostasis of intestinal intraepithelial lymphocytes via non-canonical RIG-I signaling. Nat Immunol.10.1038/s41590-019-0513-z. (IF=21)

Comment in:

Nature Reviews immunology, 2019 Dec;19(12):721. Commensal viruses contribute to gut health.

38. H Ma*, W Tao*, and S Zhu#. 2019. T Lymphocytes in Intestinal Mucosa: Defense and Tolerance. Cell Mol Immunol. (2019) 16:216–224. (Invited review) (IF=9)

37. A Wang and S Zhu#. 2019. Gut Viruses Firm the “Great Wall”. Precision Clinical Medicine.doi.org/10.1093/pcmedi/pbz027.

36. W Zhang and S Zhu#. 2019. Gut metabolites: make orphans adopted. Precision Clinical Medicine.doi:10.1093/pcmedi/pbz012.

35. A Wang*, G Zhang*, W Tao*, S Zhu#. 2019. The immune response towards enteric virus in inflammatory bowel disease. 2019. Chin J Inflamm Bowel Dis. January 2019, Vol.3, No.1 (Invited review)

34. W Tao, S Zhu#. 2019. Gut virome in health and disease. Journal of Biology, 2019, 36(6): 1-. (Invited review)

33. J Wang, MF. Sanmamed, I Datar, T Su, L Ji, J Sun, L Chen, Y Chen, G Zhu, L Zheng, T Zhou, T Badri, S Yao, S Zhu, A Boto, M Sznol, I Melero, DA. Vignali, K Schalper and L Chen#. 2018. Fibrinogen-like protein 1 is a major ligand of LAG-3 for T-cell suppression and the evasion of tumor immunity. Cell. 176, 1–14.doi:org/10.1016/j.cell.2018.11.010. (IF=32)

 

2018

32. S Ding, S Zhu, L Ren, N Feng, X Ge, B Li, RA Flavell, HB Greenberg#. 2018. Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells. Elife. 2018 Nov 21;7. pii: e39494. doi: 10.7554/eLife.39494. (IF=8)

31. L Wu, J Cao, WL Cai, SM Lang, JR Horton, DJ Jansen, ZZ Liu, JF Chen, M Zhang, BT Mott, K Pohida, G Rai, SC Kales, MJ Henderson, X Hu, A Jadhav, DJ Maloney, A Simeonov, S Zhu, A Iwasaki, MD Hall, X Cheng, GS. Shadel, Q Yan#. 2018. KDM5 histone demethylases repress immune response via suppression of STING. Plos Biology. 2018 Aug 6;16(8):e2006134. doi: 10.1371/journal.pbio.2006134. (IF=9)

30. J Tong, G Cao, T Zhang, E Sefik, M Amezcua Vesely, J Broughton, S Zhu, H Li, B Li, Lei Chen, H Chang, B Su, R Flavell# & HB Li#. 2018. m6A mRNA methylation sustains Treg suppressive functions. Cell Research. doi:10.1038/cr.2018.7 (IF=15)

 

2017

29. Zhu S*, Ding S*, Wang P, Wang G, Lei X, Palm N, Pan W, Zheng Y, Feng N, Lu J, Shan L, Abraham C, Fikrig E, Greenberg H#, Flavell R#. Nlrp9b recognizes and restricts rotavirus infection in intestinal epithelial cells. 2017. Nature. doi:10.1038/nature22967. (IF=42)

Comment in:

Nature, doi:10.1038/nature23090; Gut sensor halts viral attack

Nat Rev Gastroenterol Hepatol. doi: 10.1038/nrgastro.2017.94. Rotavirus: Inflammasome modulates rotavirus infection;

Cell Research, doi: 10.1038/cr.2017.93, NLRP9b: a novel RNA-sensing inflammasome complex.

28. Li, H.*, J. Tong*, S. Zhu*, P. Batista, J.Zhao, W. Bailis, Y. Yang, G. Wang, Y. Chen, Y. Kluger, Howard Y. Chang, Zhinan Yin#, Richard A. Flavell#. 2017. m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway. Nature. doi:10.1038/nature23450. (IF=42)

27. Pan W, Zhu S, K Qu, K Meeth, J Cheng, K He, H Ma, Y Liao, X Wen, C Roden, Z Tobiasova, Z Wei, J Zhao, J Liu, J Zheng, B Guo, M Bosenberg, R Flavell, J Lu#. 2017. Tet2 sustains the immunosuppressive function of myeloid cells and promotes melanoma growth. Immunity. 2017, doi: 10.1016/j.immuni.2017.07.020. (IF=24)

26. Yu H, Borsotti C, Schickel JN, Zhu S, Strowig T, Eynon EE, Frleta D, Gurer C, Murphy AJ, Yancopoulos GD, Meffre E, Manz MG, Flavell RA#. 2017. A novel humanized mouse model with significant improvement of class- switched, antigen-specific antibody production. Blood.  doi: 10.1182/blood-2016-04-709584. (IF=12)

25. H Yu, N Gagliani, H Ishigame, S Huber, S Zhu, E Esplugues, K Herold, L Wen, R Flavell#. 2017. Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development. Proceedings of the National Academy of Sciences, doi: 10.1073/pnas.1705599114. (IF=10)

 

2016

24. Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA#. 2016. The DNA Sensing Aim2 Inflammasome Controls Radiation Induced Cell death and Tissue Injury. Science. 2016 Nov 11;354(6313):765-768. (IF=41)

23. Shu Zhu, Geng Wang, Xuqiu Lei, Richard A. Flavell#. 2016. Mex3B, a coreceptor to present dsRNA to TLR3. Cell Research. 26(4):391-2. doi: 10.1038/cr.2016.29. (IF=15)

22. Cheng J, Roden CA, Pan W, Zhu S, Baccei A, Pan X, Jiang T, Kluger Y, Weissman SM, Guo S, Flavell RA, Ding Y, Lu J#. 2016. A Molecular Chipper Technology for CRISPR sgRNA Library Generation and Functional Mapping of Noncoding Regions. Nature Communication. 7:11178. doi: 10.1038/ncomms11178. (IF=12)

 

2015

21. Wang P*, Zhu S*, Yang L, Cui S, Pan W, Jackson R, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R#, Fikrig E#. Nlrp6 regulates intestinal antiviral innate immunity. Science. 2015 Nov 13;350(6262):826-30. doi: 10.1126/science.aab3145. (IF=41)

Comment in:

Science Signaling (2015) DOI: 10.1126/scisignal.aad8628; Nlrp6 keeps gut infections in check

20. Pan W*, Zhu S*, Dai D, Liu Z, Li D, Li B, Gagliani N, Zheng Y,.. Qian Y, Chen Y, Fang J, Herbst R, Richman L, Jallal B, Harley J, Flavell R, Yao Y# and Shen N#. 2015. MiR-125a targets effector programs to stabilize Treg mediated immune homeostasis and controls autoimmunity. Nature Communications. DOI: 10.1038/ncomms8096. (*co-first author) (IF=12)

19. Song X, Dai D, He X, Zhu S, Yao Y, Gao H, Wang J, Qu F, Qiu J, Wang H, Li X, Shen N, Qian Y#. 2015. Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage. Immunity. doi:10.1016/j.immuni.2015.06.024. (IF=24)

18. W Pan, S Zhu, D Dai, J Harley, N Shen#. 2015. T cell transfer Model of Colitis. Bio-protocol. 10.21769/BioProtoc.1862

 

2014

17. Zhu S, Li HB, Flavell RA#. 2014. Resemble and Inhibit: when RLR meets TGF-b. Molecular Cell. Dec 18;56(6):719-20. doi:10.1016/j.molcel.2014.12.010. (IF=14)

16. Zhu S, Jackson R, Flavell RA#. 2014. The lock-washer: a reconciliation of the RIG-I activation models. Cell Research.10.1038/cr.2014.5. (IF=15)

15. Marcel R. de Zoete*, Noah W. Palm*, Shu Zhu*, Richard A. Flavell#. 2014. Inflammasomes. Cold Spring Haber Perspectives in Biology. Oct 16;6(12):a016287. doi: 10.1101/cshperspect.a016287 (*co-first author) (IF=12)

14. Song X, Gao H, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y#. 2014. Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis. Immunity. 40 (1), 140-152. (IF=24)

13. W Pan, S Zhu, D Dai, J Harley, N Shen#. 2014. Mir-125a Is Critical Regulator for Controlling Autoimmunity in Multiple Autoimmune Diseases through Stabilizing Treg Mediated Immune Homeostasis.Arthritis & Rheumatology.66():S1245, OCT 2014. (IF=8)

 

2013

12. Zhu S#, Pan W, Qian Y#. 2013. MicroRNA in immunity and autoimmunity. J Mol Med. Sep;91(9):1039-50. doi: 10.1007/s00109-013-1043-z. (#co-corresponding author; Invited review) (IF=5)

11. Cao J, Zhu S, Zhou W, Li J, Liu C, Xuan H, Yan J, Zheng L, Zhou L, Yu J, Chen G, Huang Y, Yu Z, Feng L#. 2013. PLZF Mediates the PTEN/AKT/FOXO3a Signaling in Suppression of Prostate Tumorigenesis. PLoS One. 8 (12), e77922. (IF=4)

 

2012

10. Zhu, S.*, W. Pan*, X. Song, Y. Liu, Y. Tang, H. Wang, W. Liu, Y. Shi, D. He, J.B. Harley, N. Shen and Y. Qian#. 2012. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nature Medicine. 18: 1077-1086. DOI 10.1038/nm.2815. (IF=33)

Comment in:

Nature Medicine (2012) 18, 1009–1010; MiR-23b is a safeguard against autoimmunity.

9. Zhu, S. & Qian, Y#. 2012. IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential. Clin Sci (Lond) 122, 487-511. (Invited review) (IF=5)

8.Yao Y., Y. Wang, F. Chen, Y. Huang, S. Zhu, Q. Leng, H. Wang, Y. Shi, Y. Qian#. 2012. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogen. Cell Research. 04/2012; (IF=15)

7. Qu F, Gao H, Zhu S, Shi P, Zhang Y, Liu Y, Jallal B, Yao Y, Shi Y, Qian Y#. 2012. TRAF6-Dependent Act1 Phosphorylation by the I kappa B Kinase-Related Kinases Suppresses Interleukin-17-Induced NF-kappa B Activation. Mol Cell Biol 32: 3925-3937. (IF=4)

 

2011

6. Song, X., S. Zhu, P. Shi, Y. Liu, Y. Shi, S.D. Levin, and Y. Qian#. 2011. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nature Immunology. 12:1151-8. (IF=22)

5. Shi, P., S. Zhu, Y. Lin, Y. Liu, Z. Chen, Y. Shi, and Y. Qian#. 2011. Persistent stimulation with interleukin-17 desensitizes cells through SCFbeta-TrCP-mediated degradation of Act1. Science Signaling. 4:ra73. (IF=7)

4. Shi P, Zhu S and Y Qian#. 2011. IL-17 mediated signaling and function. Chin J Cell Bio. 2011, 33(4): 345-357. (Invited review)

 

2010

3. Zhu, S., W. Pan, P. Shi, H. Gao, F. Zhao, X. Song, Y. Liu, L. Zhao, X. Li, Y. Shi, and Y. Qian#. 2010. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. J Exp Med. 207:2647-2662. (IF=15)

Research highlight in:

Nature Medicine (2011) 17:52; Immunology: Taming IL-17 inflammation

Nature Immunology (2011) 12:19; TRAF3 suppresses IL-17R

2. Pan, W*, S. Zhu*, M. Yuan, H. Cui, L. Wang, X. Luo, J. Li, H. Zhou, Y. Tang, and N. Shen#. 2010. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol. 184:6773-6781. (*co-first author; 331 citations) (IF=5)

 

2009

1. Yu, Z., P. Ji, J. Cao, S. Zhu, Y. Li, L. Zheng, X. Chen, and L. Feng#. 2009. Dazl promotes germ cell differentiation from embryonic stem cells. J Mol Cell Biol. 1:93-103. (IF=6)

 

招生招聘

实验室长期招收对研究肠道免疫与微生物相互作用感兴趣的博士后、博士研究生、以及本科实习生,实验室注重多背景交叉融合,专业方向不限。



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