薛 林

薛 林

2022-01-06来源:生命科学学院

 

特任研究员  2010年博士毕业于中国科学院化学研究所,后留任助理研究员并于2013年晋升为副研究员。2013年9月至20214月先后于瑞士洛桑联邦理工学院及德国马克思普朗克医学研究所从事博士后研究(合作导师:化学生物学家Kai Johnsson教授)。

20215月加入中国科学技术大学生命科学与医学部,开展化学与生物交叉领域的研究。利用化学生物学的理论方法来解决生命及生物医学问题。开发新型蛋白质标记技术用于细胞内蛋白质的标记及示踪;构建基于蛋白质的生物传感器,研究重要生理过程如基因表达调控中重要代谢分子的生理作用,从而进一步研究其生理作用;探索高效的即时检测技术,实现对血液中重要代谢物/药物分子的医学诊断。

从事科研工作以来共发表SCI论文30篇,近年来以第一作者或通讯作者在Nat. Chem. Biol,Angew. Chem. Int. EdJ. Am. Chem. SocOrg. Lett等期刊上发表论文16总引用2000余次。其中部分研究成果获得了NCCR Chemical BiologyBiophotonics WorldScienceDailyPhys.org等多家科技媒体的推荐和报道。

https://publons.com/researcher/1825043/lin-xue/

 

主要研究兴趣:

1. 蛋白工程及蛋白质的标记与示踪

2. 基于蛋白质的光传感技术及(亚)细胞内代谢物生理作用研究

3. 血液中药物及代谢即时检测(PoCT)及其医学转换

4. 小分子荧光染料/探针的合成及生物应用

 

代表论文(*为通讯作者)

1. Lin Xue, Qiuliyang Yu, Rudolf Griss, Alberto Schena, Kai Johnsson*. Bioluminescent Antibodies for Point-of-Care Diagnostics. Angew. Chem. Int. Ed. 2017, 56, 7112−7116.

2. Lin Xue, Efthymia Prifti, and Kai Johnsson*. A General Strategy for the Semisynthesis of Ratiometric Fluorescent Sensor Proteins with Increased Dynamic Range. J. Am. Chem. Soc. 2016, 138, 5258−5261.

3. Lin Xue, Iuliia A Karpenko, Julien Hiblot, Kai Johnsson*. Imaging and manipulating proteins in live cells through covalent labeling. Nat. Chem. Biol. 2015, 11, 917–923.

4. Qiuliyang Yu, Lin Xue, Julien Hiblot, Rudolf Griss, Sebastian Fabritz, Clothilde Roux, Pierre-Alain Binz, Dorothea Haas, Jürgen G. Okun, Kai Johnsson*. Semisynthetic sensor proteins enable metabolic assays at the point of care. Science. 2018, 361, 1122–1126.

5. Guoping Li, Dongjian Zhu, Qing Liu, Lin Xue*, Hua Jiang*. A Strategy for Highly Selective Detecting and Imaging Hypochlorite Using Selenoxide Elimination. Org. Lett. 2013, 15, 2002−2005. 

6. Guoping Li, Dongjian Zhu, Qing Liu, Lin Xue*, Hua Jiang*. Rapid Detection of Hydrogen Peroxide Based on Aggregation Induced Ratiometric Fluorescence Change. Org. Lett. 2013, 15, 924−927. 

7. Guoping Li, Dongjian Zhu, Lin Xue*, Hua Jiang*. Quinoline-based fluorescent probe for ratiometric detection of lysosomal pH. Org. Lett. 2013, 15, 5020–5023. 

8. Dongjian Zhu, Guoping Li, Lin Xue*, Hua Jiang*. Development of ratiometric near-infrared fluorescent probes using analyte-specific cleavage of carbamate. Org. Biomol. Chem. 2013, 11, 4577−4580.

9. Qing Liu, Guoping Li, Dongjian Zhu, Lin Xue*, Hua Jiang*. Design of quinoline-based fluorescent probe for the ratiometric detection of cadmium in aqueous media. Chin. Chem. Lett. 2013, 24, 479−482.

10. Lin Xue, Qing Liu, Hua Jiang*. Ratiometric Zn2+ Fluorescent Sensor and New Approach for Sensing Cd2+ by Ratiometric Displacement. Org. Lett. 2009, 11, 3454−3457.

11. Lin Xue, Guoping Li, Dongjian Zhu, Qing Liu, Hua Jiang*. Rational Design of a Ratiometric and Targetable Fluorescent Probe for Imaging Lysosomal Zinc Ions. Inorg. Chem. 2012, 51, 10842−10849. 

12. Lin Xue, Guoping Li, Cailan Yu, Hua Jiang*. A Ratiometric and Targetable Fluorescent Sensor for Quantification of Mitochondrial Zinc Ions. Chem.- Eur. J. 2012, 18, 1050−1054.

13. Lin Xue, Guoping Li, Qing Liu, Huanhuan Wang, Chun Liu, Xunlei Ding, Shenggui He*, Hua Jiang*. Ratiometric Fluorescent Sensor Based on Inhibition of Resonance for Detection of Cadmium in Aqueous Solution and Living Cells. Inorg. Chem. 2011, 50, 3680−3690.

14. Lin Xue, Zhangjian Fang, Guoping Li, Huanhuan Wang, Hua Jiang*. Ratiometric Fluorescent Sensor for Detecting Zinc Ions in Aqueous Solution and Living Cells with Two-photon Microscopy. Sens. Actuators. B Chem. 2011, 156, 410−415. 

15. Lin Xue, Chun Liu, Hua Jiang*. Highly Sensitive and Selective Fluorescent Sensor for Distinguishing Cadmium from Zinc Ions in Aqueous Media. Org. Lett. 2009, 11, 1655−1658. 

16. Lin Xue, Chun Liu, Hua Jiang*. A Ratiometric Fluorescent Sensor with a Large Stokes Shift for Imaging Zinc Ions in Living Cells. Chem. Commun. 2009, 1061−1063. 

17. Lin Xue, Huanhuan Wang, Xiaojun Wang, Hua Jiang*. Modulating Affinities of Di-2-picolylamine (DPA)-Substituted Quinoline Sensors for Zinc Ions by Varying Pendant Ligands. Inorg. Chem. 2008, 47, 4310−4318. 

 

实验室招聘副研究员、助理研究员,常年招收博士后、研究生和本科实习生。诚挚欢迎对本实验室研究方向感兴趣的优秀人才加盟。应聘条件:热爱科研,有上进心,具有良好的独立工作能力和团队合作精神。具备化学生物学、生物化学、有机化学、分子生物学或细胞生物学背景

电邮:linxue@ustc.edu.cn

 

 


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