黄 的

黄 的

2020-09-23来源:生命科学与医学部


特任研究员,博士生导师。2016年博士毕业于中国科学技术大学,2017年至2022年在杜克大学医学中心从事博士后研究工作,20228月加入中国科学技术大学生命科学与医学部。主要研究兴趣为肿瘤微环境中代谢紊乱与肿瘤免疫逃逸的关系,通过探索肿瘤发生发展的分子机制,为肿瘤治疗提供潜在药物靶点和新策略。主要工作发表于Nature Cell Biology, Nature Metabolism, Trends in Cell Biology, Nature Communications, Cell Research, Cell Reports等期刊上。

 

主要研究兴趣与方向

1. 探索特定代谢物调控肿瘤免疫的作用与机制

2. 肿瘤神经浸润对肿瘤发生发展调控机制的研究

3. 药物引起肿瘤细胞衰老对肿瘤治疗的影响和意义

4. 抗肿瘤新药的筛选与探索

 

代表论文

1.  D Huang, Y Wang, JW Thompson, T Yin, PB Alexander, D Qin, P Mudgal, H Wu, Y Liang, L Tan, C Pan, L Yuan, Y Wan, QJ Li, and XF Wang. (2022). Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression. Nature Cell Biology. 24: 230–241.

2.  D Huang, PB Alexander, QJ Li, and XF Wang. (2022). GABAergic signaling beyond synapses: an emerging target for cancer therapy. Trends in Cell Biology. S0962-8924(22)00195-7.

3.  S Li*, D Huang*, S Shen, Y Cai, S Xing, G Wu, Z Jiang, Y Hao, M Yuan, N Wang, L Zhu, R Yan, D Yang, L Wang, Z Liu, X Hu, R Zhou, K Qu, A Li, X Duan, H Zhang, and P Gao. (2020). Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis. Nature Metabolism.2: 256-269. (*Equal contribution)

4.  X Ma*, L Wang*, D Huang*, Y Li, D Yang, T Li, F Li, L Sun, H Wei, K He, F Yu, D Zhao, L Hu, S Xing, Z Liu, K Li, J Guo, Z Yang, X Pan, A Li, Y Shi, J Wang, P Gao, and H Zhang.(2017). Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway. Nature Communications. 8: 1506. (*Equal contribution)

5.  D Huang*, T Li*, L Wang, L Zhang, R Yan, K Li, S Xing, G Wu, L Hu, W Jia, S Lin, C. V. Dang, L Song, P Gao, and H Zhang.(2016). Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress. Cell Research. 26:1112-1130. (*Equal contribution)

6.  D Huang, T Li, X Li, L Zhang, L Sun, X He, X Zhong, D Jia, L Song, G. L. Semenza, P Gao, and H Zhang. (2014). HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression. Cell Reports. 8: 1930-1942.

7.  D Huang, C Li, and H Zhang. (2014). Hypoxia and cancer cell metabolism. Acta Biochim Biophys Sin.46: 214-219.

8.  Y Zhang, C Li, C Hu, Q Wu, Y Cai, S Xing, H Lu, L Wang, D Huang, L Sun, T Li, X He, X Zhong, J Wang, P Gao, Z J Smith, W Jia, and H Zhang. (2019) Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1. EMBO Reports. 20: e48115.

9.  L Yuan, L Zhai, L Qian, D Huang, Y Ding, H Xiang, X Liu, J. W Thompson, J Liu, YH He, XQ Chen, J Hu, QP Kong, M Tan, and XF Wang (2018). Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death. Cell Research. 28:625-643.

10.Y Ding, C Gong, D Huang, R Chen, P Sui, KH. Lin, G Liang, L Yuan, H Xiang, J Chen, T Yin, PB. Alexander, QF Wang, EW Song, QJ Li, KC. Wood, and XF Wang. (2018) Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers. Nature Communications.9: 4274.

11.G Wu, M Yuan, S Shen, X Ma, J Fang, L Zhu, L Sun, Z Liu, X He, D Huang, T Li, C Li, J Wu, X Hu, Z Li, L Song, K Qu, H Zhang, and P Gao. (2017) Menin enhances c-Myc-mediated transcription to promote cancer progression. Nature Communications. 8: 15278.

12.Y Cao, W Guo, S Tian, X He, X Wang, X Liu, K Gu, X Ma, D Huang, L Hu, Y Cai, H Zhang, Y Wang, and P Gao. (2015). miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency. EMBO Journal. 34: 609-623.

13.X Ma, C Li, L Sun, D Huang, T Li, X He, G Wu, Z Yang, X Zhong, L Song, P Gao, and H Zhang. (2014). Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1. Nature Communications. 5: 5212.

 

实验室招聘具有细胞生物学、分子生物学、免疫学研究背景的博士后与助理研究员,要求具备独立思考与独立开展科研工作的能力、善于沟通、为人真诚,待遇从优。同时诚挚欢迎对本课题组感兴趣的本科生、研究生前来交流和学习。

 

联系方式

办公室: 生物楼6楼连廊北侧

E-mail: huangde@ustc.edu.cn


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