主要研究兴趣:
NK细胞免疫治疗相关卡控点的发现
NK细胞抑制性受体与肿瘤微环境的相关性研究
中国科学技术大学生命科学与医学部特任教授。2016年获得中国科学技术大学细胞生物学博士。主要从事NK细胞免疫治疗相关卡控点的发现以及其与肿瘤微环境的相关性研究,获得国家自然科学基金委优秀青年科学基金项目、面上项目两项、青年基金项目,参与(骨干)科技部重点研发计划两项。主要工作以第一作者和/或通讯作者发表于Sci Adv、J Hematol Oncol、Hepatology、Cancer Immunol Res、Cancer Res、Cell Mol Immunol等学术期刊。
主要代表论文:
Bi J*, Cheng C, Zheng C, Huang C, Zheng X, Wan X, Chen YH, Tian Z, Sun H*. TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity. Sci Adv. 2021;7(38):eabi6515.
Li YY, Zhang Y, Cao GS, Zheng XD, Sun C, Wei HM, Tian ZG, Xiao WH, Sun R*, Sun HY*. Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors. J Hematol Oncol. 2021;14(1).
Zhang C, Wang H, Li J, Hou X, Li L, Wang W, Shi Y, Li D, Li L, Zhao Z, Li L, Aji T, Lin R, Shao Y, Vuitton DA, Tian Z, Sun H*, Wen H*. Involvement of TIGIT in Natural Killer Cell Exhaustion and Immune Escape in Patients and Mouse Model With Liver Echinococcus multilocularis Infection. Hepatology. 2021;74(6):3376-93.
Cao GS, Cheng Y, Zheng XD, Wei HM, Tian ZG, Sun R*, Sun HY*. All-trans retinoic acid induces leukemia resistance to NK cell cytotoxicity by down-regulating B7-H6 expression via c-Myc signaling. Cancer Commun. 2021;41(1):51-61.
Cheng Y, Zheng X, Wang X, Chen Y, Wei H, Sun R, Tian Z*, Sun H*. Trispecific killer engager 161519 enhances natural killer cell function and provides anti-tumor activity against CD19-positive cancers. Cancer Biol Med. 2020;17(4):1026-38.
联系方式信息:
邮箱:haoyusun@ustc.edu.cn