主要研究兴趣：
光是生命之源。生物体的光感知系统不仅提供视觉能力，还调控机体一系列重要的生理功能，一旦受损则会造成严重的视觉疾病。就“光与生命”这一主题，薛天教授主要进行以下方面的研究
1、生命体如何感光-光感受的信号转导机制，特别是自感光视网膜神经节细胞（ipRGCs）的光信号转导机制。
2、光调控生命体生理功能-非成像视觉神经环路，如夜间异常光诱发抑郁样表型的神经环路结构与功能
3、探索基因编辑、干细胞技术和纳米新材料在大动物模型中治疗视网膜感光细胞退化疾病中的应用。如结合视觉神经生物医学与纳米技术，首次实现哺乳动物裸眼红外图像视觉；对于视觉神经系统遗传性疾病，采用在体同源重组的基因编辑技术，挽救感光细胞退化小鼠视觉；解析人类与非人灵长类恒河猴视网膜衰老分子图谱；建立首例非人灵长类视网膜色素变性猕猴模型等。
博士 教授 博导 中国科学技术大学人力资源部部长 生命科学与医学部执行部长 微尺度物质科学国家研究中心“神经环路与脑认知部”主任 长期从事光感受神经生物学的光信号转导、神经环路以及视觉再生修复等方面研究。
至今共发表SCI论文49篇，多篇通讯作者论文发表在Nature、Cell等学术期刊，被引用4000余次, h-index 27。获国家创新人才计划（2012），优秀青年基金 (2013)，重大科学研究计划青年973项目首席科学家（2013），中科院脑科学卓越中心骨干（2014），国际研究资助组织Human Frontier Science Program (HFSP) Young Investigator Grants（2014），国家自然科学基金委杰出青年基金（2019），国家重点研发计划项目首席科学家（2020）。担任国务院学术委员会第八届学科评议组成员、教育部高等学校生物技术与生物工程类专业教学指导委员会委员、中国生理学会常务理事、中国神经科学学会、中国细胞生物学学会理事、中国生物物理学会组织建设工作委员会主任等学术任职。
教育和研究经历：
1995-2000年， 中国科学技术大学少年班系（强化班），获学士学位
2000-2005年， 美国约翰霍普金斯大学医学院，获分子生理学博士学位
2006-2011年， 美国约翰霍普金斯大学医学院神经学系，博士后
2011-2012年， 美国约翰霍普金斯大学医学院神经学系，助理研究员
2012年至今， 合肥微尺度物质科学国家研究中心，教授
2012年至今， 中国科学技术大学生命科学学院，教授
获奖情况:
1. 2003 American Heart Association (AHA) Scientific Sessions Selected Late-Breaking Science
2. 2004 NIH Stem Cells Scholarship at the Keystone Stem Cells Symposium, NIH
3. 2006 BEST BASIC SCIENCE PAPER by Circulation, AHA
4. 2007 Final list of Life Science Research Foundation Fellowships
5. 2012 国家创新人才计划
6. 2013 国家自然科学基金委优秀青年基金
7. 2014 Human Frontier Science Program (HFSP)，Young Investigator Grants
8. 2019 2019年度“中国生命科学十大进展”
9. 2019 Cell杂志2019年最佳论文
10. 2019 国家自然科学基金委杰出青年基金
11. 2020 2020年度“中国神经科学重大进展”
学术任职:
2020-至今 国务院学术委员会第八届学科评议组成员
2019-至今 教育部生物技术与生物工程教学指导委员会，委员
2019-至今 中国医师协会眼科医师分会基础与临床转化专委会，委员
2019-至今 中国神经科学学会，理事
2018-至今 海峡两岸医药卫生交流协会眼科专委会眼干细胞学组，副组长
2018-至今 中国生理学会，常务理事
2018-至今 中国生物物理学会“组织建设工作委员会”主任委员
2015-至今 中国细胞生物学学会，理事
2015-至今 安徽省细胞生物学会，副理事长
相关科研成果报道
中国科大在夜间光诱导负性情绪研究方面取得进展
中国科大在基因编辑视网膜感光细胞治疗遗传性致盲疾病中取得进展
发表论文：
代表论文：(# equal contributions, *co-corresponding authors，†lead contact)
1. Meng JJ#, Shen JW#, Guang L, Ouyang CJ, Hu JX, Li ZS, Zhao H, Shi YM, Zhang M, Liu R, Chen JT, Ma YQ, Zhao H and Xue T *† (2023). Light modulates glucose metabolism by a retina-hypothalamus-brown adipose tissue axis. Cell. 2023, 186 (2), 398-412.
2. Hu JX#, Shi YM#, Zhang JM, Huang XF, Wang Q, Zhao H, Shen JW, Chen ZP, Song W, Zheng P, Zhan SL, Sun YP, Cai PF, An K, Ouyang CJ, Zhao BZ, Zhou QX, Xu L, Xiong W, Zhang Z, Meng JJ, Chen JT, Ma YQ, Zhao H, Zhang M, Qu K, Hu J, Luo MH, Xu FQ, Chen XW, Xiong Y, Bao J*, and Xue T*† (2022). Melanopsin retinal ganglion cells mediate light-promoted brain development. Cell. 185, 3124-3137.e15
3. Ma Y#, Bao J#*, Zhang Y#, Li Z, Zhou Z, Zhou X, Wan C, Huang L, Zhao Y, Han G*, Xue T*† (2019). Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae. Cell 177, 243-255 e215. Cell Best of 2019, Cell press (9 Best Articles which published in Cell in 2019)
4. Wei M#, Sun YP#, Li SZ#, Chen YN, Li LF, Fang MH, Shi RH, Tong DL, Chen JT, Ma YQ*, Qu K*, Zhang M*, Xue T*† (2023). Single-cell profiling reveals Müller glia coordinate retinal intercellular communication during light/dark adaptation via thyroid hormone signaling. Protein & Cell. 14(8) :603-617
5. Yi WY#, Lu YF#, Zhong SJ#, Zhang M#*, Sun L, Dong H, Wang MD, Wei M, Xie HH, Qu HQ, Peng RM, Hong J, Yao ZQ,Tong YY,Wang W, Ma Q, Liu ZY, Ma YQ, Li SZ, Yin CH, Liu JW, Ma C, Wang XQ*,Wu Q*, and Xue T*† (2021). A single-cell transcriptome atlas of the aging human and macaque retina, National Science Review 8, nwaa179, https://doi.org/10.1093/nsr/nwaa179
6. An K#, Zhao H#*, Miao Y, Xu Q, Li YF, Ma YQ, Shi YM, Shen JW. Meng JJ, Yao YG, Zhang Z, Chen JT, Bao J, Zhang M and Xue T*† (2020). A Circadian Rhythm-gated Subcortical Visual Circuit for Nighttime Light Induced Depressive-like Behaviors, Nature Neuroscience 23, 869-880.
7. Xie H#, Zhang W#, Zhang M#*, Akhtar T, Li Y, Yi W, Sun X, Zuo Z, Wei M, Fang X, Yao Z, Dong K, Zhong S, Liu Q, Shen Y, Wu Q, Wang X, Zhao H, Bao J, Qu K*, Xue T*† (2020). Chromatin accessibility analysis reveals regulatory dynamics of developing human retina and hiPSC derived retinal organoids. Science Advances 6, eaay5247.
8. Cai Y#, Cheng T#, Yao Y#, Li X, Ma Y, Li L, Zhao H, Bao J, Zhang M*, Qiu Z*, Xue T*† (2019). In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway. Science Advances 5, eaav3335.
9. Xue T*, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW* (2011). Melanopsin Signaling in Mammalian Iris and Retina. Nature 479, 67-73. (Faculty of 1000: f1000.com/13360986).
其他论文：
10. Rao F*, Xue T* (2024). Circadian-independent light regulation of mammalian metabolism. Nature Metabolism 6, 1000–1007. （Review）
11. Li D, Gao X, Ma X, Wang M, Cheng C, Xue T, Gao F, Shen Y, Zhang J*, Liu Q* (2024). Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization. Cell Metabolism 36(5):1059-1075.e9.
12. Xu H#, Wang S#, Fang M, Luo S, Chen C, Wan S, Wang R, Tang M, Xue T, Li B*, Lin J*, Qu K* (2023). SPACEL: deep learning-based characterization of spatial transcriptome architectures. Nature Communications 14(1):7603.
13. Wang HW, Wang S*, Zhou JY, Deng HX, Sun SS, Xue T, Ma YQ*, Gong XL* (2023). Bio-Inspired Semi-Active Safeguarding Design with Enhanced Impact Resistance via Shape Memory Effect. Advanced Functional Materials 33, 2212093.
14. Xiang N#, Li YJ#, Liu MY, Wu QQ, Zhang YX, Jin HZ, Wang Q, Li YW, Tong DL, Xue T, Jin TC*, Bao W, Chen Z* (2023). Antibody responses following the surge of SARS-CoV-2 Omicron infection among patients with systemic autoimmune rheumatic diseases. Rheumatology Advances in Practice 7(2):rkad064.
15. Ghanam AR, Ke SW, Wang SJ, Elgendy R, Xie CY, Wang SQ, Zhang R, Wei M, Liu WG, Cao J, Zhang Y, Zhang Z, Xue T, Zheng Y, Song XY(2023). Alternative transcribed 3' isoform of long non-coding RNA Malat1 inhibits mouse retinal oxidative stress.iScience 26(1):105740.
16. Zhou P, Shen JW, Liang J, Xue T, Sun YS, Zhang LH*, Tian CL* (2023). Metabolic state oscillations in cerebral nuclei detected using two-photon fluorescence lifetime imaging microscopy,Chinese Chemical Letters Volume 34, Issue 1.
17. Tong DL#, Zhang M#, Yang YR#, Xia H#, Tong HY, Zhang HJ, Zeng WH, Liu MZY, Wu Y, Ma H, Hu X, Liu WY, Cai Y, Yao YF, Yao YC, Liu KP, Shan SF, Li YJ, Gao G, Guo WW, Peng Y, Chen SH, Rao JH, Zhao JX, Min J, Zhu QJ, Zheng YM, Liu LX, Shan C, Zhong K, Qiu ZL*, Jin TC*, Chiu S*, Yuan ZM*, Xue T*† (2023). Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques. Protein & Cell. 14(1):69-73
18. Khan MH#, Huang X#, Tian X, Ouyang C, Wang D, Feng S, Chen J, Xue T*, Bao J*, and Zhang X* (2022). Short- and long-term effects of 3.5-23.0 Tesla ultra-high magnetic fields on mice behaviour. European Radiology 10.1007/s00330-022-08677-8.
19. Li B, Zhang W, Guo C, Xu H, Li L, Fang M, Hu Y, Zhang X, Yao X, Tang M, Liu K, Zhao X, Lin J, Cheng L, Chen F, Xue T, Qu K*(2022). Benchmarking spatial and single-cell transcriptomics integration methods for transcript distribution prediction and cell type deconvolution. Nature Methods 19(6):662-670.
20. Tang HD, Dong WY, Hu R, Huang JY, Huang ZH, Xiong W, Xue T, Liu J*, Yu JM*, Zhu X*, Zhang Z* (2022). A neural circuit for the suppression of feeding under persistent pain. Nature Metabolism https://doi.org/10.1038/s42255-022-00688-5
21. Ren J, Xue T, Wang L.(2022). Shining more light on G protein signalling modules: a novel optogenetic tool for Gq activation. Science China Life Science, doi: 10.1007/s11427-022-2150-1. Online ahead of print
22. Zou G, Xia J, Luo HY, Xiao D, Jin J, Miao CJ, Zuo X, Gao QQ, Zhang Z, Xue T, You YZ, Zhang Y, Zhang L, Xiong W* (2022). Combined alcohol and cannabinoid exposure leads to synergistic toxicity by affecting cerebellar Purkinje cells. Nature Metabolism4, 1138–1149.
23. Li L, Zhao H*, Xie H, Akhtar T, Yao Y, Cai Y, Dong K, Gu Y, Bao J, Chen J, Zhang M, Zhong K, Xu W*, Xue T*† (2021). Electrophysiological characterization of photoreceptor-like cells in human inducible pluripotent stem cell-derived retinal organoids during in vitro maturation. Stem Cells 39，959-974.
24. Li SZ#, Hu YZ#, Li YQ#, Hu M, Wang WC, Ma YQ, Cai Y, Wei M, Yao YC, Wang Y, Dong K, Gu YH, Zhao H, Bao J, Qiu ZL, Zhang M*, Hu XT*, Xue T*† (2021). Generation of nonhuman primate retinitis pigmentosa model by in situ knockout of RHO in rhesus macaque retina. Science Bulletin 66, 374-385.
25. Cheng P#, Tian X#, Tang W, Cheng J, Bao J, Wang H, Zheng S, Wang Y, Wei X, Chen T, Feng H, Xue T, Goda K, and He H. (2021). Direct control of store-operated calcium channels by ultrafast laser. Cell Research 7, 758-772.
26. Huang X#, Huang P#, Huang L#, Hu Z, Liu X, Shen J, Xi Y, Yang Y, Fu Y, Tao Q, Lin S, Xu A, Xu F, Xue T, So KF*, Li H*, and Ren C*† (2021). A Visual Circuit Related to the Nucleus Reuniens for the Spatial-Memory-Promoting Effects of Light Treatment. Neuron 109, 347-362 e347.
27. Li X#, Zhang J#*, Li D, He C, He K, Xue T, Wan L, Zhang C, and Liu Q*†. (2021). Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory. Neuron 109, 957-970 e8.
28. Zhang J, Gao F, Ma Y, Xue T, Shen Y*(2021). Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease. iScience. 24(11):103327.
29. Wang Y, Zeng W, Lin B, Yao Y, Li C, Hu W, Wu H, Huang J, Zhang M, Xue T, Ren D, Qu L, Cang C*(2021). CLN7 is an organellar chloride channel regulating lysosomal function. Science Advances 7(51):eabj9608.
30. Zhu X, Tang HD, Dong WY, Kang F, Liu A, Mao Y, Xie W, Zhang X, Cao P, Zhou W, Wang H, Farzinpour Z, Tao W, Song X, Zhang Y, Xue T, Jin Y, Li J, Zhang Z*.(2021)Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states.Nature Neuroscience 24(4):542-553.
31. Guo W, Fan S, Xiao D, Dong H, Xu G, Wan Z, Ma Y, Wang Z, Xue T, Zhou Y, Li Y, Xiong W*. (2021). A Brainstem reticulotegmental neural ensemble drives acoustic startle reflexes. Nature Communications 12(1):6403.
32. Liu Q#, Su LY#*, Sun C, Jiao L, Miao Y, Xu M, Luo R, Zuo X, Zhou R, Zheng P, Xiong W, Xue T, and Yao YG*† (2020). Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation. Redox Biology 34, 101560.
33. Lu Y#, Shiau F#, Yi W#, Lu S, Wu Q, Pearson J, Kallman A, Zhong S, Hoang T, Zuo Z, Zhao F, Zhang M, Tsai N, Zhuo Y, He S, Zhang J, Stein-O’Brien G, Sherman T, Duan X, Fertig D, Goff L, Zack J, Handa J, Xue T*, Bremner R*, Blackshaw S*,Wang X* and Clark B*† (2020). Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development. Developmental Cell. 53, 473-491.
34. Akhtar T, Xie H, Khan MI, Zhang M*, Xue T*† (2019). Accelerated photoreceptor differentiation of hiPSC-derived retinal organoids by contact co-culture with retinal pigment epithelium, Stem Cell Research, 39, 101491.
35. Yu N, Huang L, Zhou Y*, Xue T*, Chen Z*, and Han G* (2019). Near-Infrared-Light Activatable Nanoparticles for Deep-Tissue-Penetrating Wireless Optogenetics. Advanced Healthcare Materials, e1801132. (Review)
36. Huang L, Xi Y, Peng Y, Yang Y, Huang X, Fu Y, Tao Q, Xiao J, Yuan T, An K, Zhao H, Pu M, Xu F, Xue T, Luo M, So KF, Ren C*† (2019). A Visual Circuit Related to Habenula Underlies the Antidepressive Effects of Light Therapy. Neuron 102, 128-142 e128.
37. Zhu H#, Wang N#, Yao L, Chen Q, Zhang R, Qian J, Hou Y, Guo W, Fan S, Liu S, Zhao Q, Du F, Zuo X, Guo Y, Xu Y, Li J, Xue T, Zhong K, Song X, Huang G*, Xiong W*† (2018). Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain. Cell173, 1716-1727 e1717.
38. Ye F, Huang Y, Li J, Ma Y, Xie C, Liu Z, Deng X, Wan J, Xue T, Liu W, Zhang M (2018). An unexpected INAD PDZ tandem-mediated PLCbeta binding in Drosophila photo receptors. Elife 7.doi:10.7554/eLife.41848
39. Deng K, Shen J, Wang W, Li M, Li H, Chen C, Zhao H, Zhang M, Xue T, Liu Q, Lui VWY, Hong B*, Lin W* (2018). Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer. Cancer biology & therapy 20, 52-64.
40. Deng WL, Gao ML, Lei XL, Lv JN, Zhao H, He KW, Xia XX, Li LY, Chen YC, Li YP, Pan D, Xue T, Jin, Z. B* (2018). Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients. Stem Cell Reports 10,1267-1281.
41. Tang J, Qin N, Chong Y, Diao Y, Yiliguma, Wang Z, Xue T, Jiang M, Zhang J*, Zheng G* (2018). Nanowire arrays restore vision in blind mice. Nature Communications 9, 786.
42. Cheng J, Huang X, Liang Y, Xue T, Wang L*, Bao J* (2018). Plasticity of Light-induced Concurrent Glutamatergic and GABAergic Quantal Events in the Suprachiasmatic Nucleus. Journal of Biology Rhythms 33, 65-75.
43. Huang DF, Wang MY, Yin W, Ma YQ, Wang H, Xue T, Ren DL*, and Hu B*†. (2018). Zebrafish Lacking Circadian Gene per2 Exhibit Visual Function Deficiency. Frontiers in Behavioral Neuroscience 12, 53.
44. Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Lin A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y, Yu X(2017). A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. Journal of Clinical Investigation 127, 2631-2646.
45. Wang Q, Yue WWS, Jiang Z, Xue T, Kang SH, Bergles DE, Mikoshiba K, Offermanns S, Yau KW (2017). Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle. Current Biology 27, 1791-1800.
46. Liu CH, Gong Z, Liang ZL, Liu ZX, Yang F, Sun YJ, Ma ML, Wang YJ, Ji CR, Wang YH, Wang MJ, Cui FA, Lin A, Zheng WS, He DF, Qu C, Xiao P, Liu CY, Thomsen ARB, Joseph Cahill T, Kahsai AW, Yi F, Xiao KH, Xue T, Zhou Z, Yu X, Sun JP (2017). Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. Nature Communications 8, 14335.
47. Wen M, Guo X, Sun P, Xiao L, Li J, Xiong Y, Bao J, Xue T, Zhang L, Tian C (2015). Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells. Chemical Communications (Camb) 51, 8153-6.
48. Hu QX, Dong JH, Du HB, Zhang DL, Ren HZ, Ma ML, Cai Y, Zhao TC, Yin XL, Yu X, Xue T, Xu ZG, Sun JP (2014). Constitutive Gαi Coupling Activity of VLGR1 and its Regulation by PDZD7. Journal of Biology Chemistry 289, 24215-2
49. Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Park T, Zambidis E, Meyer J, Gamm MD, Yau KW, Canto-Soler MV (2014). Generation of three dimensional retinal tissue with functional photoreceptors from human iPSCs. Nature Communications5, 4047.
50. Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L Jr, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai SI, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, Diantonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ (2013). Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. PNAS 110, 4045-50.
51. Pearson RA, Barber AC, Rizzi M, Hippert C, Xue T, West EL, Duran Y, Smith AJ, Chuang JZ, Azam SA, Luhmann UFO, Benucci A, Sung CH, Carandini M, Yau KW, Sowden JC, Ali RR (2012). Restoration of vision after transplantation of photoreceptors. Nature485, 99-103.
52. Do MT, Kang SH, Xue T, Zhong H, Liao HW, Bergles DE, Yau KW (2009) Photon capture and signalling by melanopsin retinal ganglion cells. Nature457, 281-7. (Faculty of 1000: f1000.com/1144855).
53. Luo DG, Xue T, Yau KW (2008) How vision begins: An odyssey. PNAS 105, 9855-62 (Review)
54. Fu YB#, Kefalov V#, Luo DG#, Xue T#, Yau KW (2008). Quantal noise from human red cone pigment. Nature Neuroscience 11, 565-71
55. Xue T, Siu CW, Lieu DK, Lau CP, Tse HF, Li RA (2007). Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels. Circulation115, 1839-1850.
56. El-Kholy W, MacDonald PE, Fox JM, Bhattacharjee A, Xue T, Gao X, Zhang Y, Stieber J, Li RA, Tsushima RG, Wheeler MB. (2007) Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells. Molecular Endocrinology21, 753-764.
57. Tse HF, Xue T, Lau CP, Siu CW, Wang K, Zhang QY, Tomaselli GF, Akar FG, Li RA (2006). A bio-artificial sinus node constructed via in vivo gene transfer of an engineered pacemaker (HCN) channel reduces the dependence on electronic pacemaker in a sick sinus syndrome model. Circulation114, 1000-1011. Issue highlights, GROUND-BREAKING STUDY OF 2007 AHA.
58. Ardehali H, Xue T, Dong P, Machamer C (2005). Targeting of the mitochondrial membrane proteins to the cell surface for functional studies. Biochemical and Biophysical Research Communications 338, 1143-51.
59. Abraham MR, Henrikson CA, Tung L, Chang MG, Aon M, Xue T, Li RA, O'Rourke B, Marban E (2005). Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circulation Research 97, 159-67.
60. Moore JC, van Laake LW, Braam SR, Xue T, Tsang SY, Ward D, Passier R, Tertoolen LL, Li RA, Mummery CL (2005). Human embryonic stem cells: Genetic manipulation on the way to cardiac cell therapies. Reproductive Toxicology 20, 377-91.
61. Azene EM, Xue T, Marban E, Tomaselli GF, Li RA (2005). Non-equilibrium behavior of HCN channels: Insights into the role of HCN channels in native and engineered pacemakers. Cardiovascular Research 67, 263-73.
62. Wang G#, Xue T#, Tsang SY, Wong J, Cheng L, Zhang J, Li GR, Lau CP, Li RA, Tse HF (2005). Electrophysiological properties of pluripotent human and mouse embryonic stem cells. Stem Cells 23, 1526-34.
63. Xue T#, Cho H#, Akar F#, Tsang SY, Jones S, Marbán E, Tomaselli GF, Li RA (2005). Functional Integration of Electrically Active Cardiac Derivatives from Genetically Engineered Human Embryonic Stem Cells with Quiescent Recipient Ventricular Cardiomyocytes. Insights into the Development of Cell-Based Pacemakers. Circulation 11, 111-20. Issue highlights, Best Paper Award, Circulation 2005
64. Xue T, Sato K, Kodama K, Ennis I, French RJ, Li RA (2003). Novel interactions identified between µ-conotoxin and the Na+ channel Domain I P-loop: Implications for toxin-pore binding geometry. Biophysical Journal85, 2299-310.
65. Azene EM#, Xue T#, Li RA (2003). Molecular basis of the effects of potassium on heterologously-expressed pacemaker (HCN) channels. Journal of Physiology547, 349-356.
66. Henrikson CA, Xue T, Dong P, Sang D, Marbán E, Li RA (2003). Identification of a surface charged residue in the S3-S4 linker of pacemaker (HCN) channel that influences activation gating. Journal of Biology Chemistry 278, 13647-54.
67. Li RA, Ennis I, Xue T, Nguyen HM, Tomaselli GF, Goldin AL, Marbán E (2003). Molecular basis of isoform-specific µ-conotoxin block of cardiac, skeletal muscle and brain Na channels. Journal of Biology Chemistry 278, 8717-24.
68. Xue T, Li RA (2002). An external determinant in the S5-P linker of the pacemaker (HCN) channel identified by sulfhydryl modification. Journal of Biology Chemistry277, 46233-42.
69. Xue T, Marbán E, Li RA (2002). Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: Insights into structure-function relationships and multimerization. Circulation Research90, 1267-1273.
70. Li RA, Sato K, Kodama K, Kohno T, Xue T, Tomaselli GF, Marban E. (2002). Charge conversion enables quantification of the proximity between a normally-neutral mu-conotoxin (GIIIA) site and the Na+ channel pore. FEBS Letters511, 159-164.
招生招聘：
实验室招聘神经生物学（电生理）、干细胞和分子生物学等相关背景的博士后和特任（副）研究员，待遇从优。同时热忱欢迎对本实验室研究方向感兴趣的本科生前来攻读博士学位。
联系方式： xuetian@)ustc.edu.cn
联系电话： 63600971
实验室网页：http://www.xuelab.ustc.edu.cn/ （光与生命实验室）
Researcher ID : http://www.researcherid.com/rid/G-9009-2018