1999年于上海交通大学生命科学院获理学学士学位。2005于中国科学院上海生物化学与细胞生物学研究所获细胞生物学博士学位。2005年至2012年先后在美国纽约州立大学Wadsworth研究中心和美国国家癌症研究所从事博士后研究工作。2012入选 “国家创新人才青年项目”，2013年起任中国科学技术大学生命科学与医学部教授，2019年起兼任中国科学技术大学附属第一医院特任教授。成果以第一和通讯作者发表在Nature Metabolism，Nature Cell Biology，Journal of Cell Biology，Cell Research，Cancer Research, Nature Communications等刊物。现任中国细胞生物学会肿瘤细胞生物学、医学细胞生物学、细胞结构与功能分会;中国抗癌协会肿瘤代谢专业委员会委员，担任多个国际专业杂志的审稿人。
研究兴趣：
1. 非整倍肿瘤细胞分裂及其免疫和代谢调控;
2. 肿瘤化疗耐药机理，联合靶向治疗和免疫治疗新策略；
3. 细胞分裂调控与恶性肿瘤发生、发展的关系;
主要代表性论文
1. Cheng A#, Xu T#, You W, Wang T, Zhang D, Guo H, Zhang H, Pan X, Wang Y, Liu L, Zhang K, Shi J, Yao X, Guo J*, Yang Z*. A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells. Nat. Metab. 2023 Jun 22. doi: 10.1038/s42255-023-00832-9
2. Jiang Y, Wang T, Sheng D, Han C, Xu T, Zhang P, You W, Fan W, Zhang Z, Jin T, Duan X, Yuan X, Liu X, Zhang K, Ruan K, Shi J, Guo J, Cheng A*, Yang Z*. 2022. Aurora A-mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression. J Biol. Chem. 298(11):102561.
3. Cheng A#, Jiang Y#, Wang T, Yu F, Ishrat I, Zhang D, Ji X, Chen M, Xiao W, Li Q, Zhang K, Niu G, Shi J, Pan Y*, Yang Z*, Guo J*. 2021. Energy restriction causes metaphase delay and chromosome mis-segregation in cancer cells. Cell Cycle. 20(12): 1195-1208.
4. Cheng A#, Zhang P#, Wang B#，Yang D#, Duan X, Jiang Y, Xu T, Jiang Y, Shi J, Ding C, Wu G, Sang Z, Wu Q, Wang H, Wu M , Zhang Z, Pan X, Pan Y, Gao P, Zhang H, Zhou C, Guo J* and Yang Z*. 2019. Aurora-A Mediated Phosphorylation of Lactate Dehydrogenase B promotes glycolysis and tumor growth by relieving the substrate inhibition effect. Nat. Commun.2019, 10(1):5566.
5. Yin T#, Zhao ZB#, Guo J#, Wang T, Yang JB, Wang C, Long J, Ma S, Huang Q, Zhang K, Ma X, Liu C, Liu S, Lian ZX*, Yang Z*. 2019. Aurora-A inhibition eliminates myeloid cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in breast cancer. Cancer Res. 2019 Mar 22. Highlighted article.
6. Yu F, Jiang Y, Lu L, Cao M, Qiao Y, Liu X, Liu D, Van Dyke T, Wang F, Yao X, Guo J* and Yang Z*2017. Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B Feedback Loop in late G2 phase. Cell Discovery 3, 16049
7. Ma X, Wang L, Huang, Li Y, Yang D, Li T, Li F, Sun L, Wei H, He K, Yu F, Zhao D, Hu L, Xing S, Liu Z, Li K, Guo J, Yang Z, Pan X, Li A, Shi Y, Wang J, Gao P, Zhang H. 2017. Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway. Nat. Commun. 8(1):1506.
8. Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y and Zhu X. 2012. Misfolded Gbeta2 is recruited to cytoplasmic dynein by Nudel for efficient clearance. Cell Res.22:1140-1154.
9. Yang Z., Kenny A., Brito D. and Rieder C. 2009. Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments. J Cell Biol.186: 675-684.
10.Yang Z., Loncarek J., Khodjakov A. and Rieder C. 2008. Extra centrosomes and/or chromosomes prolong mitosis in human cells. Nat .Cell Biol. 10: 748-751.
11.Brito D.*, Yang Z.* and Rieder C. 2008. Microtubules do not promote mitotic slippage when the Spindle Assembly Checkpoint cannot be satisfied. J Cell Biol.182(4):623-9. (* Co-first author)
12.Yang Z., Tulu S., Wadsworth P. and Rieder C. 2007. Kinetochore Dynein is Required for Normal Chromosome Motion and Congression Independent of the Spindle Checkpoint. Curr. Biol.17(11): 973-80.
13.Guo J., Yang Z., Song W., Chen Q., Wang F., Zhang Q. and Zhu X. Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly. Mol Biol Cell. 17(2):680-689. 2006.
14.Yang Z., Guo J., Chen Q., Du J., Ding C., and Zhu X.2005. Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death. Mol. Cell. Biol. 25: 4062-4074.
15.Yang, Z., Guo J., Li N., Qian M., Wang S, and. Zhu X. 2003. Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport. Cell Res.13:275-83.
招生招聘：实验室招收致力于肿瘤细胞生物学研究的博士后、硕博研究生和本科实习生。
ResearcherID: https://orcid.org/my-orcid?orcid=0000-0001-7797-5891