主要研究方向：
1.研究由lncRNA和三维基因组空间结构组成的三维空间转录调控在脑衰老中的作用
2.研究lncRNA和染色质相互作用在减数分裂和精子发生过程中的转录调控作用
教授 博士生导师 毕业于北京师范大学生物系 1996年和1999年分别获得学士和硕士学位 2006年在美国罗彻斯特大学生物系取得分子、细胞和发育生物学博士学位 2006-2012年在加州大学圣地亚哥分校进行博士后研究 期间获得癌症研究所博士后奖学金资助。2012年12月加入中国科学技术大学生命科学学院。多年来一直从事基因转录调控、长链非编码RNA（lncRNA）、三维基因组空间结构等相关研究，在Genome Research、Cell Death Differentiation、Genes Development、Nucleic Acids Research等学术期刊上发表了系列文章。
代表性学术论文:
1. Cheng Q., Zhao W., Song X.*, Jin T.* Machine-learning and scRNA-Seq-based diagnostic and prognostic models illustrating survival and therapy response of lung adenocarcinoma. Genes and Immunity. 2024, Jul 29. doi: 10.1038/s41435-024-00289-0. Epub ahead of print.
2. Wang Q.#, Chen P.#, Wang X.#, Wu Y., Xia K., Mu X., Xuan Q., Xiao J., He Y., Liu W., Song X.*, Sun F*. piR-36249 and DHX36 together inhibit testicular cancer cells progression by upregulating OAS2. Noncoding RNA Research. 2023, 8(2):174-186.
3. Luo Z.#, Zhang R.#, Hu T.#, Zhu Y., Wu Y., Li W., Zhang Z., Yao X., Liang H., Song X.*. NicE-C efficiently reveals open chromatin-associated chromosome interactions at high resolution. Genome Research. 2022, Feb 1: gr.275986.121. doi: 10.1101/gr.275986.121. Online ahead of print. *Corresponding author.
4. Wang F.#, Wang Q.#, Liu B.#, Mei L., Ma S., Wang S., Wang R., Zhang Y., Niu C., Xiong Z., Zheng Y., Zhang Z., Shi J., Song X.*. The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum. Cell Death & Differentiation. 2021, 28(9):2634-2650. *Corresponding author.
5. Cheng Q., Wu Y, Xia H.*, Song X.*. RGL2 as an age-dependent factor regulates colon cancer progression. Computational and Structural Biotechnology Journal. 2021, 19: 2190-2201. *Corresponding author.
6. Luo Z.*#, Hu T. *, Jiang H., Wang R., Xu Q., Zhang S., Cao J., Song X.*. Rearrangement of macronucleus chromosomes correspond to TAD-like structures of micronucleus chromosomes in Tetrahymena thermophila. Genome Research. 2020. Mar 12. 30(3):406-414. *Corresponding author.
7. Luo Z.#, Wang X.#, Jiang H.#, Wang R.#, Chen J., Chen Y., Xu Q., Cao J., Gong X., Wu J., Yang Y., Li W., Han C., Cheng YC., Rosenfeld MG., Sun F.*, Song X.*. Reorganized 3D genome structures support transcriptional regulation in mouse spermatogenesis. iScience. 2020, 23(4): 101034. *Corresponding author.
8. Ghanam AR., Cao J., Ouyang X., and Song X.*. New insights into chronological mobility of retrotransposable elements in vivo. Oxidative Medicine and Cellular Longevity. 2019. 2818415. eCollection 2019. *Corresponding author.
9. Wang F.#, Ren D.#, Liang X.#, Ke S., Zhang B., Hu B.*, Song X.*, Wang X.*. A long noncoding RNA cluster-based genomic locus maintains proper development and visual function. Nucleic Acids Research. 2019, 47(12): 6315-6329. *Corresponding author.
10. Xu Q.#, Wang R.#, Ghanam AR., Yan G., Miao W., Song X.*. The key role of CYC2 during meiosis in Tetrahymena thermophila. Protein & Cell. 2016, 7(4):236-49. *Corresponding author.
11. Cao J., Luo Z., Cheng Q., Xu Q., Zhang Y., Wang F., Wu Y., Song X.*. Three-dimensional regulation of transcription. Protein & Cell. 2015, 6(4):241-53. *Corresponding author.
12. Song X., Bowen J., Miao W., Liu Y., and Gorovsky MA.*. The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation. Genes & Development. 2012, 26(6):615-29. *Corresponding author.
13. Song X.#, Wang X.#, Arai S. and Kurokawa R.*. Promoter-associated noncoding RNA from the CCND1 promoter. Methods in Molecular Biology. 2012, 809:609-22. #Co-first author.
14. Harismendy O.#, Notani D.#, Song X., Rahim NG., Tanasa B., Heintzman N., Ren B., Fu XD., Topol EJ., Rosenfeld MG*, and Frazer KA*. 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature. 2011, 470(7333):264-8. #Co-first author.
15. Wang X.# and Song X.#, Glass CK., and Rosenfeld MG*. The Long Arm of Long Noncoding RNAs: Roles as Sensors Regulating Gene Transcriptional Programs. Cold Spring Harb Perspect Biol. 2011, 3(1):a003756. #Co-first author. Collected in《The RNA World》IV. #Co-first author
16. Wang X., Arai S.%, Song X.%, Reichart D., Du K., Pascual G., Tempst P., Rosenfeld MG.#, Glass CK.#, and Kurokawa R.#. Induced ncRNAs allosterically modify RNA binding proteins in cis to inhibit transcription. Nature. 2008, 454(7200):126-30. %Co-second author
17. Song, X.#, Gjoneska E.#, Ren Q.#, Taverna SD., Allis C.D., and Gorovsky MA.*. Phosphorylation of the SQ H2A.X motif is required for proper meiosis and mitosis in Tetrahymena thermophila. Mol Cell Biol. 2007, 27(7):2648-60. *Co-first author.
18. Song X. and Gorovsky MA.*. Unphosphorylated H1 is enriched in a specific region of the promoter when CDC2 is down-regulated during starvation. Mol Cell Biol. 2007, 27(5):1925-33.
19. Shang Y., Song X., Bowen J., Corstanje R., Gao Y., Gaertig J., and Gorovsky MA.*. A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila. PNAS. 2002, 99(6):3734-9.
实验室招聘实验员、硕博研究生和本科实习生。同时招聘具有分子生物学及生物信息学等相关背景的博士后，待遇从优。
联系方式： E-mail:songxy5@ustc.edu.cn.
电话：63607752.
ResearcherID :http://www.researcherid.com/rid/P-1094-2014