主要研究兴趣：
1. 人类肝脏NK细胞免疫属性及功能调控，
2. 生物大数据分析肝脏时空异质性，
3. 人NK细胞免疫治疗靶点发现与验证。
教授 博士生导师 中科大第一附属医院器官移植免疫实验室主任 2012年获中国科技大学生命学院博士学位 中国科学院院长奖获得者 2014年获中国免疫学会青年学者奖 2015年获美国肿瘤免疫治疗协会(Society for Immunotherapy of Cancer, USA)国际青年学者奖 2020年获安徽省杰出青年基金支持 国家基金委优秀青年基金支持。
中华医学会器官移植学分会委员，《中国免疫学杂志》编委。包括以第一或通讯作者在Hepatology、Nature Communications、Cancer Immunol Res，Cancer Research等学术期刊发表研究论文23篇。
近期学术论文：
1. Sun H(#), Huang Q, Huang M, Wen H, Lin R, Zheng M, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z(*), Sun C(*). Human CD96 correlates to NK cell exhaustion and predicts the prognosis of human hepatocellular carcinoma. Hepatology. 2018 Nov 8. doi: 10.1002/hep.30347.
2. Sun C(#), Lan P(#), Han Q(#), Huang M, Zhang Z, Xu G, Song J, Wang J, Wei H, Zhang J, Sun R, Zhang C, Tian Z(*). Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion. Nature Communications. 2018 Mar 28;9(1):1241.
3. Sun H(#), Liu L, Huang Q, Liu H, Huang M, Wang J, Wen H, Lin R, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z, Sun C(*). Accumulation of Tumor-Infiltrating CD49a+ NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma. Cancer Immunol Res. 2019 Sep;7(9):1535-1546.
4. Sun H(#), Xu J, Huang Q, Huang M, Li K, Qu K, Wen H, Lin R, Zheng M, Wei H, Xiao W, Sun R, Tian Z(*), Sun C(*). Reduced CD160 Expression Contributes to Impaired NK-cell Function and Poor Clinical Outcomes in Patients with HCC. Cancer Res. 2018 Sep 19.CAN-18-1049.
5. Sun C(#), Fu B, Gao Y, Liao X, Sun R, Tian Z(*), Wei H(*). TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence. PLoS Pathogens. 2012;8(3):e1002594.
6. Sun C(#)(*), Xu J, Huang Q, Huang M, Wen H, Zhang C, Wang J, Song J, Zheng M, Sun H, Wei H, Xiao W, Sun R, Tian Z(*). High NKG2A Expression Contributes to NK Cell Exhaustion and Predicts a Poor Prognosis of Patients with Liver Cancer. Oncoimmunology. Volume 6, 2017 6(1):e1264562.
7. Sun C(#), Sun H, Zhang C, Tian Z(*). NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma. Cell Mol Immunol. 2015 May;12(3):292-302.
8. Sun C(#), Sun HY, Xiao WH, Zhang C, Tian Z(*). Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy. Acta Pharmacol Sin. 2015 Oct;36(10):1191-9.
9. Wu T(#), Li F, Chen Y, Wei H, Tian Z, Sun C(*), Sun R(*). CD4+ T Cells Play a Critical Role in Microbiota-Maintained Anti-HBV Immunity in a Mouse Model. Front Immunol. 2019 Apr 30;10:927.
10. Sun H(#)(*), Sun C(*). The Rise of NK Cell Checkpoints as Promising Therapeutic Targets in Cancer Immunotherapy. Front Immunol. 2019 Oct 17;10:2354.
11. Sun H(#), Song J, Weng C, Xu J, Huang M, Huang Q, Sun R, Xiao W, Sun C(*). Association of decreased expression of the macrophage scavenger receptor MARCO with tumor progression and poor prognosis in human hepatocellular carcinoma. J Gastroenterol Hepatol. 2017 May;32(5):1107-1114.
12. Sun H(#), Xu J, Huang M, Huang Q, Sun R, Xiao W, Sun C(*). CD200R, a co-inhibitory receptor on immune cells, predicts the prognosis of human hepatocellular carcinoma. Immunol Lett. 2016 Oct;178:105-13.
13. Yuwei Wu(#), Jinyu Wang(#), Xiaodong Zheng, Yongyan Chen, Mei Huang, Qiang Huang, Weihua Xiao, Haiming Wei, Zhigang Tian, Rui Sun(*)，Sun C(*) Establishment and Preclinical Therapy of Patient-derived Hepatocellular Carcinoma Xenograft Model. Immunol Lett. Volume 223, July 2020
14. Sun C(#), Xu J, Song J, Liu C, Wang J, Weng C, Sun H, Wei H, Xiao W, Sun R, Tian Z(*). The predictive value of centre tumour CD8⁺ T cells in patients with hepatocellular carcinoma: comparison with Immunoscore. Oncotarget. 2015 Nov 3;6(34):35602-15.
15. Sun H(#), Sun C, Tian Z, Xiao W. NK cells in immunotolerant organs. Cell Mol Immunol. 2013 May;10(3):202-12.
16. Sun H(#)(*), Sun C, Xiao W, Sun R. Tissue-resident lymphocytes: from adaptive to innate immunity. Cell Mol Immunol. 2019 Mar;16(3):205-215.
实验室网页：http://sun.ustc.edu.cn
招生招聘：
课题组实验技术体系成熟，平台设施完备，长期公开招聘生物医学或生物信息学方面相关博士后，特任副教授，同时欢迎上述背景的本科生来本实验室攻读博士学位。
联系方式：
电话0551-63600547 邮箱charless@ustc.edu.cn