博士 特任教授 博导
本科、博士和博士后均在清华大学完成，师从施一公教授。2017年，加入中国科学技术大学开展独立研究工作。长期从事膜蛋白结构生物学研究，迄今已在Nature、Science、Nature Plants等杂志发表研究论文20余篇。担任中国生物化学与分子生物学会蛋白质专业分会第四届委员会委员、安徽省生物化学与分子生物学学会第八届理事会理事。获2017年“求是杰出青年学者奖”，2019年“仲英青年学者”奖等。
教育和研究经历：
2005-2009年，清华大学生物科学与技术系，获学士学位
2009-2014年，清华大学大学生命科学学院，获理学博士学位
2014-2017年，清华大学大学生命科学学院，博士后
2017年至今，中国科学技术大学生命科学学院，特任教授、博导
获奖情况：
2009年，获江苏隆力奇-清华大学生物学奖学金
2012年，获博士研究生国家奖学金
2014年，获清华大学优秀博士学位论文二等奖
2014年，获生命科学联合中心研究奖三等奖学金
2014年，获生命科学联合中心博士后特等基金
2016年，获聘清华大学结构生物学高精尖创新中心“卓越学者”
2017年，求是杰出青年学者
2019年，仲英青年学者
研究方向：
主要从事植物激素跨膜运输和信号传导的分子机制研究，运用结构生物学和生物化学等手段，阐释关键蛋白介导相关过程的结构基础和工作机理。研究成果包括：首次揭示了植物生长素极性运输蛋白PIN1的结构和功能机制（Nature, 2022）；阐释了介导植物脱落酸细胞外排过程的ABCG25蛋白的工作机理（Nature Plants, 2023）；鉴定了植物首个油菜素甾醇运输蛋白ABCB19，并阐释了其分子机理（Science, 2024）。
代表性成果：
1. Wei Ying*, Yaowei Wang*, Hong Wei* , Yongming Luo*, Qian Ma, Heyuan Zhu, Hilde Janssens, Nemanja Vukašinović, Miroslav Kvasnica, Johan M Winne, Yongxiang Gao, Shutang Tan, Jiří Friml, Xin Liu#, Eugenia Russinova#, Linfeng Sun#. (2024). Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. Science, 383(6689). (#, corresponding author)
2. Chunqiao Sun*, Bangguo He*, Yongxiang Gao, Xingbing Wang#, Xin Liu#, Linfeng Sun#. (2024). Structural insights into the calcium-coupled zinc export of human ZnT1. Science Advances, 10(17):eadk5128. (#, corresponding author)
3. W. Ying*, L. Liao*, H. Wei*, Y. Gao, X. Liu#, L. Sun#. (2023). Structural basis for abscisic acid efflux mediated by ABCG25 in Arabidopsis thaliana. Nature Plants, 9(10):1697-1708. (#, corresponding author)
4. Jing Xia*, Mengjuan Kong*, Zhisen Yang*, Lianghanxiao Sun, Yakun Peng, Yanbo Mao, Hong Wei, Wei Ying, Yongxiang Gao, Jiří Friml, Jianping Weng#, Xin Liu#, Linfeng Sun#, Shutang Tan#. (2023). Chemical inhibition of Arabidopsis PIN-FORMED auxin transporters by the anti-inflammatory drug naproxen. Plant Communications, 4(6):100632. (#, corresponding author)
5. X. Wang*, Y. Li*, H. Wei*, Z. Yang*, R. Luo, W. Zhang#, X. Liu#, L. Sun#. (2023). Molecular architecture and gating mechanisms of the Drosophila TRPA1 channel. Cell Discovery, 9(1):36. (#, corresponding author)
6. M. Kong, X. Liu, L. Sun#, S. Tan#. (2022). Molecular mechanisms of N-1-naphthylphthalamic acid, a chemical tool in plant biology and agriculture. Molecular Horticulture, 2, 22. (#, corresponding author)
7. T. Tian*, L. Chen*, Z. Dou*, Z. Yang*, X. Gao#, X. Yuan, C. Wang, R. Liu, Z. Shen, P. Gui, M. Teng, X. Meng, D. Hill, L. Li, X. Zhang, X. Liu, L. Sun#, J. Zang#, X. Yao#. (2022). Structural insights into human CCAN complex assembled onto DNA. Cell Discovery, 8, 90. (#, corresponding author)
8. Z. Yang, J. Xia, J. Hong, C. Zhang, H. Wei, W. Ying, C. Sun, Lianghanxiao Sun, Y. Mao, Y. Gao, S. Tan, J. Friml, D. Li, X. Liu#, L. Sun#. (2022). Structural insights into auxin recognition and efflux by Arabidopsis PIN1. Nature, https://doi.org/10.1038/s41586-022-05143-9. (#, corresponding author)
9. Y. Li*, Y. Ding*, L. Qu, X. Li, Q. Lai, P. Zhao, Y. Gao, C. Xiang, C. Cang#, X. Liu#, L. Sun#. (2022). Structure of the Arabidopsis guard cell anion channel SLAC1 suggests activation mechanism by phosphorylation. Nature Communications, 13(1):2511. (#, corresponding author)
10. Y. Zhou*, L. Liao*, C. Wang, J. Li, P. Chi, Q. Xiao, Q. Liu, L. Guo, L. Sun#, D. Deng#. (2020). Cryo-EM structure of the human concentrative nucleoside transporter CNT3. PLoS Biology, 18(8):e3000790. (#, corresponding author)
11. Y. Li*, Y. Hu*, J. Wang, X. Liu#, W. Zhang#, L. Sun#. (2020). Structural insights into a plant mechanosensitive ion channel MSL1. Cell Reports, 30, 1–10. (#, corresponding author)
12. L. Wang*, W. Hou*, L. Chen, Y. Jiang, D. Xu, L. Sun#, C. Zhou#, Y. Chen#. (2020). Cryo-EM structure of human bile salts exporter ABCB11. Cell Research, 2020 0:1–3; https://doi.org/10.1038/s41422-020-0302-0. (#, corresponding author)
13. L. Chen*, W. Hou*, T. Fan, B. Liu, T. Pan, Y. Li, Y. Jiang, W. Wen, Z. Chen, L. Sun#, C. Zhou#, Y. Chen#. (2020). Cryo-electron Microscopy Structure and Transport Mechanism of a Wall Teichoic Acid ABC Transporter. mBio, 2020 Mar 17;11(2). (#, corresponding author)
14. D. Xu*, Z. Feng*, W. Hou, Y. Jiang, L. Wang, L. Sun#, C. Zhou#, Y. Chen#. (2019). Cryo-EM structure of human lysosomal cobalamin exporter ABCD4. Cell Research, 2019 Aug 29.
15. X. Liu, J. Wang#, L. Sun#. (2018). Structure of the hyperosmolality-gated calcium permeable channel OSCA1.2. Nature Communications, 9(1):5060. (#, corresponding author)
16. Y. Liu*, H. Hu*, J. Wang*, Q. Zhou, P. Wu, N. Yan, HW. Wang, JW. Wu, L. Sun#. (2018). Cryo-EM structure of L-fucokinase/GDP-fucose pyrophosphorylase (FKP) in Bacteroides fragilis. Protein & Cell, https://doi.org/10.1007/s13238-018-0576-x. (#, corresponding author)
17. Sun L*, Zhou R*, Yang G*, Shi Y. (2017). Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase. Proceedings of the National Academy of Sciences of the United States of America, 114(4), E476-E485. (*, co-first author)
18. Sun L, Li X, Shi Y. (2016). Structural biology of intramembrane proteases: mechanistic insights from rhomboid and S2P to γ-secretase. Current Opinion in Structural Biology, 37, 97–107.
19. Sun L*, Zhao L*, Yang G*, Yan C*, Zhou R*, Zhou X, Xie T, Zhao Y, Wu S, Li X, Shi Y. (2015). Structural basis of human γ-secretase assembly. Proceedings of the National Academy of Sciences of the United States of America, 112(19), 6003-6008. (*, co-first author)
20. Madej MG*, Sun L*, Yan N, Kaback HR. (2014). Functional architecture of MFS D-glucose transporters. Proceedings of the National Academy of Sciences of the United States of America, 111(7), E719-727. (*, co-first author)
21. Sun L*, Zeng X*, Yan C, Sun X, Gong X, Rao Y, Yan N. (2012). Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature, 490(7420), 361-366. (*, co-first author)
22. Bai XC*, Yan C*, Yang G*, Lu P, Ma D, Sun L, Zhou R, Scheres SH, Shi Y. (2015). An atomic structure of human γ-secretase. Nature, 525(7568), 212-217. (*, co-first author)
23. Xie T*, Yan C*, Zhou R, Zhao Y, Sun L, Yang G, Lu P, Ma D, Shi Y. (2014). Crystal structure of the γ-secretase component nicastrin. Proceedings of the National Academy of Sciences of the United States of America, 111(37), 13349-13354. (*, co-first author)
24. Lu P*, Bai XC*, Ma D*, Xie T, Yan C, Sun L, Yang G, Zhao Y, Zhou R, Scheres SH, Shi Y. (2014). Three-dimensional structure of human γ-secretase. Nature, 512(7513),166-170. (*, co-first author)
25. Sugihara J, Sun L, Yan N, Kaback HR. (2012). Dynamics of the L-fucose/H+ symporter revealed by fluorescence spectroscopy. Proceedings of the National Academy of Sciences of the United States of America, 109(37), 14847-14851.
26. Dang S, Sun L, Huang Y, Lu F, Liu Y, Gong H, Wang J, Yan N. (2010). Structure of a fucose transporter in an outward-open conformation. Nature, 467(7316), 734-738.
27. Gao X*, Lu F*, Zhou L*, Dang S, Sun L, Li X, Wang J, Shi Y. (2009). Structure and mechanism of an amino acid antiporter. Science, 324(5934):1565-1568. (*, co-first author)
招生招聘：
实验室长期招聘结构生物学、生物化学、计算生物学、植物学、分子生物学等相关背景的博士后和特任（副）研究员，待遇从优。同时热忱欢迎对本实验室研究方向感兴趣的本科生前来攻读博士学位。
联系方式：sunlf17@ustc.edu.cn
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