洪 泂

洪 泂

2022-09-20来源:生命科学学院


博士、博士生导师、副教授

出生于安徽省。1989年至1993年就读于安徽师范大学生命科学学院获学士学位。1993年至1996年就读于北京师范大学生命科学学院,获硕士学位,2000年至2003年就读于日本京都大学,获博士学位。1996-2003年在北京师范大学生命科学学院工作,2003年至2006年在京都大学和石川县立大学作博士后研究,2006年至2008年在美国弗吉尼亚理工大学作博士后研究。20084月作为中国科技大学优秀人才引进,现为生命科学学院副教授。20092-6月,在美国休斯敦大学学习基于芯片的高通量DNA合成技术。共在Nucleic Acid Research, Metabolic Engineering, Bioresource Technology, Microbial Cell FactoriesSCI学术期刊发表研究论文30余篇。

  

主要研究兴趣:

  1. 基于微流芯片的高保真高通量基因合成。采用通过芯片合成的寡核苷酸为出发材料,通过高通量的扩增、纠错及组装降低DNA合成成本,提高合成效率。

  2. 利用生物质生产各种化学品的耐热工程酵母的构建。利用木质纤维素生物质以及菊芋为材料生产乙醇、木糖醇、丙酮酸、乳酸、果糖等有较高附加值的产品。

  3. 重组蛋白高温表达体系的构建。在耐热酵母及耐热丝状真菌中构建重组蛋白的表达系统

  

代表性论文

  1. Zhang, Biao, Zhu, Yelin., Zhang, Jia, Wang, Dongmei, Sun, Lianhong,Hong Jiong* , (2017). EngineeredKluyveromyces marxianusfor pyruvate production at elevated temperature with simultaneous consumption of xylose and glucose.Bioresoure Technology, 224, 553-562.

  2. Zhang, Biao, Zhang, Jia, Wang, Dongmei., Han, Ruixiang., Ding, Rui, Gao, Xiaolian., Sun, Lianhong.,Hong Jiong* , (2016).. Simultaneous fermentation of glucose and xylose at elevated temperatures co-produces ethanol and xylitol through overexpression of a xylose-specific transporter in engineeredKluyveromyces marxianus.Bioresource Technology, 216, 227-237.Best article in this issue)

  3. Zhang, Jia, Zhang, Biao., Wang Dongmei, Gao Xiaolian, Sun Lianhong andHong Jiong* , (2015). Rapid ethanol production at elevated temperatures by engineered thermotolerantKluyveromyces marxianusvia the NADP(H)-preferring xylose reductase-xylitol dehydrogenase pathway.Metabolic Engineering, 31, 140-152.

  4. Zhang Jia, Zhang Biao, Wang Dongmei, Gao Xiaolian andHong Jiong* , (2015). Improving xylitol production at elevated temperature with engineeredKluyveromyces marxianusthrough over-expressing transporters.Bioresource Technology175: 642-645.

  5. WAN, Wen; LI, Lulu; XU, Qianqian; WANG, Zhefan; YAO, Yuan; WANG, Rongliang; ZHANG, Jia; Liu, haiyan; Gao, Xiaolian*;Hong, Jiong* (2014) Error removal in microchip-synthesized DNA using immobilized MutS.Nucleic Acids Research, 42(12),e102 doi: 10.1093/nar/gku405

  6. Zhang Jia, Zhang Biao, Wang Dongmei, Gao Xiaolian,Hong Jiong* (2014) Xylitol production at high temperature by engineeredKluyveromyces marxianus.Bioresource Technology152:192-201.

  7. Wen Wan, Dongmei Wang, Xiaolian Gao andJiong Hong*Expression of family 3 cellulose-binding module (CBM3) as an affinity tag for recombinant proteins in yeastApplied Microbiology and Biotechnology. 2011 V91(3):789-798

  8. Jiong Hong, Ye Xinhao, Wang Yiran,Zhang Y-HP. Bioseparation of recombinant cellulose binding module-protein by affinity adsorption on an ultra-high-capacity cellulosic adsorbent.Analytica ChimicaActa2008Vol 621193-199.

  9. Jiong Hong, Xinhao Ye, Y-H Percival Zhang, Quantitative Determination of Cellulose Accessibility to Cellulase Based on Adsorption of a Non-Hydrolytic Fusion Protein Containing CBM and GFP with Its Applications,Langumir2007, Vol 23, 12535-12540.

  10. Jiong Hong, Yonghong Wang, Hisanori Tamaki, and Hidehiko Kumagai,Construction of thermotolerant yeast expressing thermostable cellulase genes,Journal of Biotechnology2007 Vol. 130, 114-123.

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联系方式

邮箱:hjiong@ustc.edu.cn  联系电话:0551-63600705.

网页:http://synbio.ustc.edu.cn/高晓连教授实验室

research IDhttp://www.researcherid.com/rid/N-1996-2013

  


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