中国科学技术大学生命科学与医学部教授。2006 年获南京大学生物技术学士学位；2012 年获中国科学院上海生命科学研究院博士学位，中科院院长优秀奖；2013 年起，美国耶鲁大学遗传学系博士后。2014-2017年获美国 Leukemia and Lymphoma Society Fellow Award 和基金会研究资助。2018年底入职科大。研究方向为肿瘤多维度逃逸机制探索及新型干预策略设计。近五年(2020-2024)以通讯作者在Immunity, Cell Host Microbe, Cell Stem Cell, Nature Commun, Protein Cell, Mucosal Immunol, Elife上发表多篇研究论文及评论。研究工作多次被Nat Rev Immunol, Nat Med和Nat Immunol点评以及被 Faculty 1000 收录和推荐。以第一发明人申请国家发明专利4项。
教育工作经历
2002-2006年，南京大学生命科学学院，获学士学位
2006-2012年，中科院上海生命科学研究院健康科学研究所，获细胞生物学博士学位
2013-2018年，美国耶鲁大学医学院遗传系，博士后
2018年至今，中国科学技术大学生命科学与医学部，教授，博士生导师
获奖情况
2012年 中科院院长优秀奖
2014年 美国Leukemia and Lymphoma Society Fellow Award
2018年 中组部创新人才计划
目前研究方向
肿瘤免疫治疗是肿瘤治疗领域一大创新成就。肿瘤免疫治疗重要手段之一，免疫检查点阻断治疗策略，获得2018年获得诺贝尔生理医学奖，针对性的anti-PD-1/L1抗体目前也是全世界年销售额最高的药物。尽管取得了辉煌的成就，但目前免疫检查点阻断治疗，在不同肿瘤类型中，仍然存在60%以上病人对于治疗不响应、无效，甚至在一些癌种比如结直肠癌，响应率不足10%。这提示肿瘤存在非常复杂的逃逸机制。如何寻找肿瘤新的逃逸机制？如何更好地针对这些逃逸机制设计靶向干预策略？从而更有效地提高病人对于免疫治疗的响应率？等等，是肿瘤免疫研究领域的痛点和热点，也是未来联合免疫疗法的重要方向。
我们实验室主要以结直肠癌为研究原型。结直肠癌肿瘤微环境非常复杂，涉及到多系统、多个维度互作：肠粘膜上皮系统包含肠道干细胞及其发育分化而成的多种功能上皮细胞；肠腔侧可接触到数以百亿级的肠道微生物；肠基底膜侧含有丰富而大量的免疫细胞；以及有人体第二大脑之称的肠神经系统。这个复杂的微环境系统使得肿瘤的逃逸机制也多样且复杂。围绕这个科学问题，我们重点探索结直肠癌中，肿瘤逃逸的内源（表观遗传）及外源（免疫、微生物）因素，近几年以通讯作者发表了一系列工作：
1. 在肠道肿瘤细胞中，原创发现并鉴定了哺乳动物中第一个N1组氨酸Histidine (His) 甲基化修饰METTL9，解析了其表观遗传调控模式，以及在肠道肿瘤免疫中的功能，为发展新型肿瘤免疫联合表观遗传靶向治疗提供潜在新靶点（Protein Cell 2021; Protein Cell 2023; Elife 2022; Nature Communications 2024）
2. 在肠道肿瘤微环境中，解析了致病性肠道微生物及其异常产生的代谢物小分子（DCA，Tyramine），如何与宿主上皮系统、免疫系统互作介导免疫逃逸，从而促进肠癌发生发展。并针对一些关键微生物和代谢物靶点，开发包括噬菌体清除、抗体阻断等新型肿瘤免疫联合治疗方案（Immunity 2024; Cell Host Microbe 2024；Mucosal Immunology 2024）
实验室将进一步围绕肠道肿瘤多维度逃逸机制探索及新型干预策略设计展开研究及临床应用工作。
实验室网页：panlab.ustc.edu.cn
联系方式：wenpan@ustc.edu.cn
电话：0551-63600520
发表文章
1. Li C, Zhang P, Xie Y, Wang S, Guo M, Wei X, Zhang K, Cao D, Zhou R, Wang S, Song X#, Zhu S#, Pan W#.Enterococcus derived tyramine hijacks a2A-adrenergic receptor in intestinal stem cell to exacerbate colitis. Cell Host & Microbe. 2024 (IF=30.1)
2. Cong J*, Liu P*, Ying W, Li C, Han Z, Yang J, Song X, Dai L, Sun L, Kasper D, Pan W#, Zhu S#. Bile acids modified by the microbiota suppress gut anti-tumor immune responses. Immunity. 2024 (IF=43.5)
3. Zhu S#, Pan W#. Microbial metabolite steers intestinal stem cell fate under stress. Cell Stem Cell. 2024 (IF=23.9)
4. Ren X, Liu Q, Zhou P, Zhou T, Wang D, Mei Q, Flavell RA, Liu Z#, Li M#, Pan W#, Zhu S#. DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells. Nature Communications. 2024 (IF=16.6)
5. Wu Y, Zhang P, Shi T, Cao D#, Pan W# Deficiency of immunoglobulin IgSF6 enhances antibacterial effects by promoting endoplasmic reticulum stress and the inflammatory response in intestinal macrophages. Mucosal Immunology. 2024 (IF=8.7)
6. Dan Cao, Mengyue Lv, Chi Hu, Shukai Li, Siwen Wang, Chao Xu, Wen Pan#. METTL9-catalyzed histidine methylation of S100A9 suppresses the anti-Staphylococcus aureus activity of neutrophils. Protein & Cell. 2024 (IF=20.1)
7. A Wang, W Tao, J Tong, J Gao, J Wang, G Hou, C Qian, G Zhang, R Li, D Wang, X Ren, K Zhang, S Ding, R Flavell, HB Li, W Pan#, S Zhu#. m6A modifications regulate intestinal immunity and rotavirus infection. Elife. 2022 (IF=8.1)
8. M. Lv, D. Cao, L. Zhang, C. Hu, S. Li, P. Zhang, L. Zhu, X. Yi, C. Li, A. Yang, Z. Yang, Y. Zhu, K. Zhang, Pan, W#. METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth. Protein & Cell. 2021 (IF=20.1)
9. Pan, W., K. Qu, S. Zhu, K. Meeth, J. Cheng, H. Ma, Y. Liao, X. Wen, C. Roden, Z. Tobiasova, Z. Wei, J. Zhao, J. Liu, J. Zheng, B. Guo, M. Bosenberg, R.Flavell, J. Lu.The DNA methylcytosine dioxygenaseTet2 sustains immunosuppressive function of tumor-infiltrating myeloid cells to promote melanoma progression.
Immunity. 2017. 47:284-297. (IF=43.5)
10. Zhu. S, S. Ding, P. Wang, Z. Wei, W. Pan, N. Palm, Y. Yang, H. Yu, H. Li, G. Wang, X. Lei, M. Zoete, J. Zhao, Y. Zheng, H. Chen, Y. Zhao, K. Jurado, N. Feng, L. Shan, Y. Kluger, J. Lu, C. Abraham, E. Fikrig, H. Greenberg, R. Flavell. Nlrp9b inflammasome recognizes and restricts enteric viral infection in intestinal epithelial cells. Nature. 2017. 546(7660):667-670
11. J Liu, B Guo, Z Chen, N Wang, M Iacovino, J Cheng, C Roden, W Pan, S. Khan, S. Chen, M. Kyba, R. Fan, S. Guo, Jun Lu. miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism. Blood. 2017.
12. C Roden, J Gaillard, S Kanoria, W Rennie, S Barish, J Cheng, W Pan, J. Liu, C. Cotsapas, Y. Ding, J. Lu. Novel determinants of mammalian primary microRNA processing revealed by systematic evaluation of hairpin-containing transcripts and human genetic variation. Genome research (2017) 27 (3), 374-384.
13. J. Cheng, C. Roden, W. Pan, S. Zhu, A. Baccei, X. Pan, T. Jiang, Y. Kluger, S. Weissman, S. Guo, R.Flavell, Y. Ding, J. Lu. A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions. Nature Communications. (2016) March 30; 7:11178.
14. Pan,W., D. Dai, S.Zhu, Z.Liu, D. Li, B.Li, Y.Tang, N. Gagliani, M. Weirauch, X. Chen, W. Zhu, Y. Qian, L.Richman, B. Jallal, J.B. Harley, R.Flavell, Y.Yao and N.Shen. MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis. Nature Communications. (2015) May 12.6:7096.
15. P.Wang, S.Zhu, L. Yang, S.Cui, W.Pan, R.Jackson, Y.Zheng, A.Rongvaux, LongYang, Q.Sun, G. Yang, S. Gao, R. Lin, F. You, R. Flavell, E. Fikrig. Nlrp6 regulates intestinal antiviral innate immunity. Science. 2015.
16. Jijun Cheng, Shangqin Guo, Suning Chen, Stephen J.Mastriano, Chaochun Liu, Ana C. D’Alessio, Eriona Hysolli, Yanwen Guo, HongYao, Cynthia M.Megyola, DanLi, JunLiu, WenPan, Christine Roden, XiaoLingZhou, Kartoosh Heydari, Jianjun Chen, In-Hyun Park,Ye Ding, Yi Zhang, Jun Lu. An extensive network of TET2-targeting microRNAs regulates malignant hematopoiesis. Cell Reports.2013.5:471-481.
17. Zhu,S., W.Pan, Y. Qian. 2013. MicroRNA in immunity and autoimmunity. J Mol Med. 91:1039-50.
18. Zhu,S.*, W.Pan*, X. Song, Y. Liu, Y. Tang, H. Wang, W. Liu, Y. Shi, D. He, J.B. Harley, N. Shen and Y.Qian. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKKα. Nature Medicine. 2012. 18 (7), 1077-1086 (*co-first author)
19. JiaLi, QiongFu, Huijuan Cui, Bo Qu, WenPan, NanShen, and Chunde Bao. Interferon alpha priming promotes lipid uptake and macrophage-derived foam cell formation. Arthritis & Rheumatism.2011.63:492.
20. Pan,W., S.Zhu, M.Yuan, H.Cui, L.Wang, X.Luo, J.Li, H.Zhou, Y.Tang and N.Shen. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase1.2010. J Immunol.184:6773-6781.
21. Zhu,S., W.Pan, P. Shi, H. Gao, F. Zhao, X. Song, Y. Liu, L. Zhao, X. Li, Y. Shi, and Y. Qian. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. 2010. J Exp Med. 207:2647-2662.
招生招聘
实验室长期招聘免疫、生化、结构、神经生物学等不同学科背景的博士后和特任（副）研究员，待遇从优。同时热忱欢迎感兴趣的本科生前来攻读博（硕）士学位。