博士生导师，特任研究员。
一、学习及工作经历
1997年--2001年，浙江大学生命科学学院，生物化学专业，理学学士；
2001年--2009年，中国科学院上海生物化学与细胞生物学研究所，生物化学与分子生物学专业，理学博士；
2009年--2011年，美国俄亥俄州立大学医学中心，博士后；
2011年--2018年，美国克利夫兰医学中心，博士后；
2018年--至今，中国科技大学，生命科学学院与附属第一医院，特任研究员；
二、学术成果及影响
主要从事胶质瘤干细胞(glioma stem cell, GSC) 和肿瘤微环境的相关研究。研究领域包括肿瘤免疫、肿瘤血管生成、肿瘤干细胞特异性调节分子等。在肿瘤免疫微环境研究方向，发现胶质瘤干细胞可以通过分泌POSTN蛋白来促进巨噬细胞对肿瘤的浸润，而巨噬细胞进一步支持肿瘤恶性发展，二者形成一个恶性正反馈调节回路促进肿瘤发展。在肿瘤血管系统研究方向，发现肿瘤血管周细胞来源于胶质瘤干细胞，而周细胞覆盖于血管内皮细胞，决定了血癌屏障以及药物传递效率，是化学治疗的关键靶点。在Cell, Cell Stem Cell, Nature Cell Biology, Science Translational Medicine等杂志发表论文20余篇，包括2篇ESI高引用论文，总引用次数超过3000次。
三、在研项目(仅限于主要负责人)
项目名称、来源、经费指标卡号：放疗刺激下胶质瘤干细胞通过POSTN对免疫微环境和肿瘤复发的调控及机制研究，国家自然科学基金面上项目
总经费(万元)：55
起止日期：2022-01至2025-12
项目名称、来源、经费指标卡号：胶质母细胞瘤血管周细胞的异质性及其免疫调控亚群的研究，国家自然科学基金面上项目
总经费(万元)：49
起止日期：2025-01至2028-12
四、主要研究方向（招生专业）及内容
生物学
1、细胞生物学
1）胶质瘤干细胞与肿瘤相关的巨噬细胞相互作用的分子机制；
2）胶质瘤肿瘤血管周细胞的分化与维持的分子调控机制；
3）胶质瘤干细胞干性维持相关的信号通路；
五、代表性论文（近五年）
1. Qiuhong Zhu#, Panpan Liang#, Hao Meng, Fangzhen Li, Wei Miao, Cuiying Chu, Wei Wang, Dongxue Li, Cong Chen, Yu Shi, Xingjiang Yu, Yifang Ping, Chaoshi Niu, Hai-Bo Wu, Aili Zhang*, Xiu-Wu Bian*, Wenchao Zhou*. Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells. Nat Commun. 2024 Jan 2;15(1):40.
2. Aili Zhang, Zhi Huang, Weiwei Tao, Kui Zhai, Qiulian Wu, Jeremy N Rich, Wenchao Zhou*, Shideng Bao*. USP33 deubiquitinates and stabilizes HIF‐2alpha to promote hypoxia response in glioma stem cells. EMBO J. 2022 Apr 4;41(7):e109187.
3. Aili Zhang, Weiwei Tao, Kui Zhai, Xiaoguang Fang, Zhi Huang, Jennifer S Yu, Andrew E Sloan, Jeremy N Rich, Wenchao Zhou*, Shideng Bao*. Protein sumoylation with SUMO1 promoted by Pin1 in glioma stem cells augments glioblastoma malignancy. Neuro Oncol. 2020 Dec 18;22(12):1809-1821.
4. Yang Zhang, Tianxu Kang, Yuxi Wang, Chao Song, Huan Li, Hailong Mi, Yachao Li, Minhai Dong, Xiaoyu Ma, Hongtao Zhu, Lidong Cheng, Po Zhang, Zhiye Chen, Lin Zhou, Qiulian Wu, Feng Mao, Baofeng Wang, Suojun Zhang, Kai Shu, Feng Wan, Wenchao Zhou, Jeremy N Rich, Jianying Shen*, Qungen Xiao*, Xingjiang Yu*. Low level of tumor necrosis factor α in tumor microenvironment maintains self-renewal of glioma stem cells by Vasorin-mediated glycolysis. Neuro Oncol. 2024 Aug 2:noae147. doi: 10.1093/neuonc/noae147.
5. Lishu Chen#, Qinghui Qi#, Xiaoqing Jiang#, Jin Wu#, Yuanyuan Li, Zhaodan Liu, Yan Cai, Haowen Ran, Songyang Zhang, Cheng Zhang, Huiran Wu, Shuailiang Cao, Lanjuan Mi, Dake Xiao, Haohao Huang, Shuai Jiang, Jiaqi Wu, Bohan Li, Jiong Xie, Ji Qi, Fangye Li, Panpan Liang, Qiuying Han, Min Wu, Wenchao Zhou, Chenhui Wang, Weina Zhang, Xin Jiang, Kun Zhang, Huiyan Li, Xuemin Zhang, Ailing Li, Tao Zhou*, Jianghong Man*.Phosphocreatine promotes epigenetic reprogramming to facilitate glioblastoma growth through stabilizing BRD2. Cancer Discov. 2024 Apr 2. doi: 10.1158/2159-8290.CD-23-1348.
6. Huan Li, Chao Song, Yang Zhang, Guohao Liu, Hailong Mi, Yachao Li, Zhiye Chen, Xiaoyu Ma, Po Zhang, Lidong Cheng, Peng Peng, Hongtao Zhu, Zirong Chen, Minhai Dong, Sui Chen, Hao Meng, QunGen Xiao, Honglian Li, Qiulian Wu, Baofeng Wang, Suojun Zhang, Kai Shu, Feng Wan, Dongsheng Guo, Wenchao Zhou, Lin Zhou, Feng Mao*, Jeremy N Rich*, Xingjiang Yu*. Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation. Adv Sci (Weinh). 2024 Feb;11(7):e2305620.
7. Shuya Li, Min Li, Shaohu Huo, Qin Wang, Jing Chen, Shenggang Ding, Zhutian Zeng, Wenchao Zhou, Yucai Wang*, Jun Wang*. Voluntary-Opsonization-Enabled Precision Nanomedicines for Inflammation Treatment. Adv Mater. 2021 Jan;33(3):e2006160. doi: 10.1002/adma.202006160.
8. Weiwei Tao, Aili Zhang, Kui Zhai, Zhi Huang, Haidong Huang, Wenchao Zhou, Qian Huang, Xiaoguang Fang, Briana C Prager, Xiuxing Wang, Qiulian Wu, Andrew E Sloan, Manmeet S Ahluwalia, Justin D Lathia, Jennifer S Yu, Jeremy N Rich, Shideng Bao. SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells. EMBO Mol Med. 2020 Dec 7;12(12):e12291. doi: 10.15252/emmm.202012291.
9. Weiwei Tao, Chengwei Chu, Wenchao Zhou, Zhi Huang, Kui Zhai, Xiaoguang Fang, Qian Huang, Aili Zhang, Xiuxing Wang, Xingjiang Yu, Haidong Huang, Qiulian Wu, Andrew E Sloan, S Yu Jennifer, Xiaoxia Li, George R Stark, Jeremy N Rich, Shideng Bao. Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma. Nat Commun. 2020 Jun 15;11(1):3015. doi: 10.1038/s41467-020-16827-z.
10. Shuya Li, Qin Wang, Yanqiong Shen, Muhammad Hassan, Jizhou Shen, Wei Jiang, Yitan Su, Jing Chen, Li Bai, Wenchao Zhou, Yucai Wang. Nano Lett. 2020 Jan 8;20(1):242-251. doi: 10.1021/acs.nanolett.9b03753.
11. Zhen Dong, Guoxin Zhang, Meng Qu, Ryan C Gimple, Qiulian Wu, Zhixin Qiu, Briana C Prager, Xiuxing Wang, Leo JY Kim, Andrew R Morton, Deobrat Dixit, Wenchao Zhou, Haidong Huang, Bin Li, Zhe Zhu, Shideng Bao, Stephen C Mack, Lukas Chavez, Steve A Kay, Jeremy N Rich. Cancer Discov. 2019 Nov;9(11):1556-1573. doi: 10.1158/2159-8290.CD-19-0215.
12. Xiuxing Wang, Kailin Yang, Qiulian Wu, Leo JY Kim, Andrew R Morton, Ryan C Gimple, Briana C Prager, Yu Shi, Wenchao Zhou, Shruti Bhargava, Zhe Zhu, Li Jiang, Weiwei Tao, Zhixin Qiu, Linjie Zhao, Guoxing Zhang, Xiqing Li, Sameer Agnihotri, Paul S Mischel, Stephen C Mack, Shideng Bao, Jeremy N Rich. Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells. Sci Transl Med. 2019 Aug 7;11(504):eaau4972. doi: 10.1126/scitranslmed.aau4972.
13. Stephen C Mack, Irtisha Singh, Xiuxing Wang, Rachel Hirsch, Quilian Wu, Rosie Villagomez, Jean A Bernatchez, Zhe Zhu, Ryan C Gimple, Leo JY Kim, Andrew Morton, Sisi Lai, Zhixin Qiu, Briana C Prager, Kelsey C Bertrand, Clarence Mah, Wenchao Zhou, Christine Lee, Gene H Barnett, Michael A Vogelbaum, Andrew E Sloan, Lukas Chavez, Shideng Bao, Peter C Scacheri, Jair L Siqueira-Neto, Charles Y Lin, Jeremy N Rich. Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma. J Exp Med. 2019 May 6;216(5):1071-1090. doi: 10.1084/jem.20190196.
六、联系方式
邮箱：wzaz@ustc.edu.cn
电话：0551-62284938