主要研究方向 豆科植物-根瘤菌共生固氮，植物-微生物共生
中科大生医部特任研究员、课题组长、博士生导师。1998年至2002年本科就读于浙江大学环境工程系； 2003年至2010年硕博连读于中国科学院上海生命科学研究院植物生理生态研究所, 从事植物发育生物学研究； 2010年至2017年于英国约翰﹒英纳斯研究中心（John Innes Centre, JIC）任博士后、 2018年至2019年于剑桥大学塞恩斯伯里实验室（The Sainsbury Laboratory, Cambridge University）任研究助理，从事植物-微生物共生相关研究。
实验室研究背景介绍
氮是农作物生长必须的营养元素。尽管空气中氮含量高达78%, 但并不能被农作物直接吸收利用；而豆科植物和作物如大豆、花生、豌豆和苜蓿等可以与根瘤菌形成共生、通过根瘤菌生物固氮的过程将氮气转化为植物可以利用的氮源。这种高效的天然固氮系统既节约能源、又保护环境，因此被认为是发展可持续性绿色农业的重要氮肥来源。而研究和解析豆科植物—根瘤菌共生固氮的机制，是将其高效应用于现代绿色农业的关键基础。
实验室主要从事豆科植物-根瘤菌共生固氮机制的研究，前期在豆科植物调控根瘤菌侵染的研究中，发现豆科植物中首个调控根瘤菌侵染线极性生长的豆科植物蛋白复合体(侵染复合体，infectosome)；建立豆科模式植物蒺藜苜蓿中首个根毛特异的根瘤菌侵染转录组 (root hair infectome)；解析豆科植物中首个根瘤菌侵染的基因调控网络并揭示固氮共生进化中重要转录因子的核心调控作用等。主要研究成果发表于Nature Communications、The Plant Cell、The EMBO Journal、Molecular Plant 和Plant Physiology等期刊，其中infectome系列研究成果为ESI高被引论文、侵染复合体infectosome相关发现被认为“发展了研究和理解根瘤菌侵染线发育机制的新方向”。
实验室目前研究内容
1. 豆科植物-根瘤菌共生固氮的分子机理
2. 豆科植物适应根瘤菌侵染的亚细胞系统重塑
3. 侵染复合体调控侵染线发育的细胞和分子机制
4. 根瘤菌侵染及丛枝菌根真菌侵染机制的进化
发表论文（按时间倒序，#共同第一作者， *通讯作者）
1.Qiying Xiao#, Yi Chen#, Cheng-Wu Liu#, Fran Robson, Sonali Roy, Xiaofei Cheng, Jiangqi Wen, Kirankumar Mysore, Anthony J. Miller*, Jeremy D. Murray*. MtNPF6.5 mediates chloride uptake and nitrate preference in Medicago roots. The EMBO Journal 40(21):e106847 (2021). https://pubmed.ncbi.nlm.nih.gov/34523752/
2.Cheng-Wu Liu* and Shutang Tan*. Nitrate signaling: A translator between nitrate perception and calcium signalling. Molecular Plant 14(5):718-719 (2021). https://doi.org/10.1016/j.molp.2021.04.002
3.Sonali Roy, Andrew Breakspear, Donna Cousins, Ivone Torres-Jerez, Kirsty Jean Jackson, Anil Kumar, YangYang Su, Nick Krom, Cheng-Wu Liu, Michael Udvardi, Ping Xu*, Jeremy Dale Murray*. Three common symbiotic ABC-B transporters in Medicago truncatula are regulated by a NIN-independent branch of the symbiosis signalling pathway. Mol Plant Microbe Interact. (2021)
https://pubmed.ncbi.nlm.nih.gov/33779265/
4.Weng, Lin# and Dong, Zhicheng# and Hu, Xiaohe and Li, Xin and Sato, Shusei and Ambrose, Mike and Feng, Xianzhong and He, Wei and Wang, Trevor L. and Weller, James L. and Liu, Zhongchi* and Luo, Da* and Liu, Cheng-Wu* and Yang, Jun*. KEEL LOSS1 Regulates Petal Number Along the Floral Dorsoventral Axis in Lotus japonicus and Pisum sativum. Cell Press Sneak Peek (2020) https://ssrn.com/abstract=3745289 or http://dx.doi.org/10.2139/ssrn.3745289
5.Chengwu Liu, Zhong Zhao*. The Legume SHR-SCR Module Predetermines Nodule Founder Cell Identity. Chinese Bulletin of Botany 55(6): 661-665 (2020). https://www.chinbullbotany.com/EN/10.11983/CBB20182
6.Anil Kumar#, Donna R. Cousins#, Cheng-Wu Liu, Ping Xu*, Jeremy D. Murray*. Nodule Inception Is Not Required for Arbuscular Mycorrhizal Colonization of Medicago truncatula. Plants-Basel 9(1): 71 (2020). https://doi.org/10.3390/plants9010071
7.Cheng-Wu Liu, Andrew Breakspear, Nicola Stacey, Kim Findlay, Jin Nakashima, Karunakaran Ramakrishnan, Miaoxia Liu, Fang Xie, Gabriella Endre, Fernanda de Carvlho-Niebel, Giles E. D. Oldroyd, Michael K. Udvardi, Joëlle Fournier*, Jeremy D. Murray*. A protein complex required for polar growth of rhizobial infection threads. Nature Communications 10(1):2848 (2019). doi: 10.1038/s41467-019-10029-y .https://www.ncbi.nlm.nih.gov/pubmed/31253759
8.Cheng-Wu Liu#, Andrew Breakspear#, Dian Guan, Marion R. Cerri, Kirsty Jackson, Suyu Jiang, Fran Robson, Guru V. Radhakrishnan, Sonali Roy, Caitlin Bone, Nicola Stacey, Christian Rogers, Martin Trick, Andreas Niebel, Giles E. D. Oldroyd, Fernanda de Carvalho-Niebel, Jeremy D. Murray*. NIN acts a network hub controlling a growth module required for rhizobial infection. Plant Physiology 179(4):1704-1722 (2019). https://www.ncbi.nlm.nih.gov/pubmed/30710053
9.Sonali Roy, Fran Robson, Jodi Lilley, Cheng-Wu Liu, Xiaofei Cheng, Jiangqi Wen, Simon Walker, Jongho Sun, Donna Cousins, Caitlin Bone, Malcolm J. Bennett, J. Allan Downie, Ranjan Swarup, Giles Oldroyd, Jeremy D. Murray*. MtLAX2, a functional homologue of the Arabidopsis auxin influx transporter AUX1, is required for nodule organogenesis. Plant Physiology 174: 326-338 (2017). https://www.ncbi.nlm.nih.gov/pubmed/28363992
10.James K. Hane#, Yao Ming#, Lars G. Kamphuis#, Matthew N. Nelson, Gagan Garg, Craig A. Atkins, Philipp E. Bayer, Armando Bravo, Scott Bringans, Steven Cannon, David Edwards, Rhonda Foley, Ling-ling Gao, Maria J. Harrison, Wei Huang, Bhavna Hurgobin, Sean Li, Cheng-Wu Liu, Annette McGrath, Grant Morahan, Jeremy Murray, James Weller, Jianbo Jian, Karam B. Singh*. A comprehensive draft genome sequence for lupin (Lupinus angustifolius), an emerging health food: insights into plant–microbe interactions and legume evolution. Plant Biotechnology Journal 15 (3): 318–30 (2017). https://www.ncbi.nlm.nih.gov/pubmed/27557478
11.Cheng-Wu Liu, Jeremy D. Murray*. The role of flavonoids in nodulation host-range specificity: an update. Plants-Basel 5(3):33 (2016). https://www.ncbi.nlm.nih.gov/pubmed/27529286
12.Jeremy D. Murray*, Cheng-Wu Liu, Yi Chen, Anthony J. Miller*. Nitrogen sensing in legumes. Journal of Experimental Botany 68(8):1919-1926 (2016). https://www.ncbi.nlm.nih.gov/pubmed/27927992
13.Senjuti Sinharoy, Cheng-Wu Liu, Andrew Breakspear, Dian Guan, Sarah Shailes, Jin Nakashima, Shulan Zhang, Jiangqi Wen, Ivone Torres-Jerez, Giles Oldroyd, Jeremy D. Murray, Michael K. Udvardi*. A Medicago truncatula Cystathionine Beta Synthase like domain-containing protein is required for rhizobial infection and symbiotic nitrogen fixation. Plant Physiology 170:2204-17 (2016). https://www.ncbi.nlm.nih.gov/pubmed/26884486
14.Cheng-Wu Liu, Andrew Breakspear, Sonali Roy, Jeremy D. Murray*. Cytokinin responses counterpoint auxin signaling during rhizobial infection. Plant Signaling & Behavior 10: e1019982 (2015). https://www.ncbi.nlm.nih.gov/pubmed/26176899
15.Dasong Chen, Cheng-Wu Liu, Sonali Roy, Donna Cousins, Nicola Stacey, Jeremy D. Murray*. Identification of a core set of rhizobial infection genes using data from single cell-types. Frontiers in Plant Science 6:575 (2015). https://www.ncbi.nlm.nih.gov/pubmed/26284091
16.Andrew Breakspear, Chengwu Liu, Donna R. Cousins, Sonali Roy, Dian Guan, Jeremy D. Murray. The role of hormones in rhizobial infection. Biological Nitrogen Fixation, Chapter 56. Editor Frans J. de Bruijn, Wiley-Blackwell, New York, (2015). (Book chapter) https://onlinelibrary.wiley.com/doi/abs/10.1002/9781119053095.ch56
17.Andrew Breakspear#, Chengwu Liu#, Sonali Roy, Nicola Stacey, Christian Rogers, Martin Trick, Giulia Morieri, Kirankumar S. Mysore, Jiangqi Wen, Giles E. D. Oldroyd, J. Allan Downie, Jeremy D. Murray. The root hair infectome of Medicago truncatula uncovers changes in cell cycle genes and reveals a requirement for auxin signaling in rhizobial infection. Plant Cell 26(12):4680-701 (2014). https://www.ncbi.nlm.nih.gov/pubmed/25527707
18.Spotlights in Rhizobial root hair infection requires auxin signaling. [Trends Plant Sci. 2015] https://www.ncbi.nlm.nih.gov/pubmed/25920666
19.Ertao Wang*, Nan Yu, S. Asma Bano, Chengwu Liu, Anthony J. Miller, Donna Cousins, Xiaowei Zhang, Pascal Ratet, Million Tadege, Kirankumar S. Mysore, J. Allan Downie, Jeremy D. Murray, Giles E. D. Oldroyd, Michael Schultze. A H+-ATPase that energizes nutrient uptake during mycorrhizal symbioses in rice and Medicago truncatula. Plant Cell 26(4):1818-1830 (2014). https://www.ncbi.nlm.nih.gov/pubmed/24781115
20.Jeremy D. Murray*, Donna R Cousins, Kirsty J. Jackson, Chengwu Liu. Signaling at the root surface: the role of cutin monomers in mycorrhization. Molecular Plant 6(5):1381-3 (2013). https://www.ncbi.nlm.nih.gov/pubmed/23935010
21.Dian Guan, Nicola Stacey, Chengwu Liu, Jiangqi Wen, Kirankumar S. Mysore, Ivone Torres-Jerez, Tatiana Vernié, Million Tadege, Chuanen Zhou, Zeng-yu Wang, Michael K. Udvardi, Giles E. D. Oldroyd, Jeremy D. Murray*. Rhizobial infection is associated with the development of peripheral vasculature in nodules of Medicago truncatula. Plant Physiology 162(1): 107-115 (2013). https://www.ncbi.nlm.nih.gov/pubmed/23535942
22.Chengwu Liu, Hengfu Yin, Peng Gao, Xiaohe Hu, Jun Yang, Zhongchi Liu, Xiangdong Fu, Da Luo*. PHOSPHATIDYLSERINE SYNTHASE1 is required for inflorescence meristem and organ development in Arabidopsis. Journal of Integrative Plant Biololgy 55(8): 682–695 (2013). https://www.ncbi.nlm.nih.gov/pubmed/23931744
23.Hengfu Yin, Peng Gao, Chengwu Liu, Jun Yang, Zhongchi Liu, Da Luo*. SUI-family genes encode phosphatidylserine synthases and regulate stem development in rice. Planta 237(1): 15-27 (2013). https://www.ncbi.nlm.nih.gov/pubmed/22956125
24.Zhi-cheng Dong, Zhong Zhao, Cheng-wu Liu, Jiang-hong Luo, Jun Yang, Wei-hua Huang, Xiao-he Hu, Trevor L. Wang, Da Luo*. Floral patterning in Lotus japonicus. Plant Physiology 137(4): 1272–1282 (2005). https://www.ncbi.nlm.nih.gov/pubmed/15824286
招聘信息
实验室招聘博士后/特任副研究员，要求有分子生物学、生物化学或植物学相关背景、具备独立研究能力，有植物-微生物共生研究经验者优先。无截止日期，招到为止。
欢迎对植物分子生物学，植物细胞生物学和植物-微生物共生相关研究感兴趣的同学前来实验室攻读硕士/博士研究生！
联系方式
电话：0551-63603105
地址：中国科学技术大学西校区生命科学大楼236-237室