主要研究兴趣
1. 参与抗病毒感染以及肿瘤中T淋巴细胞的转录与表观遗传调控机制
2. 常见自身免疫性疾病的发病机理以及药物研发的生物学基础
3. 髓系和淋巴系胸腺T淋巴细胞早期谱系分化的机制研究及与白血病等重大疾病的关系
教授，博士生导师、国家优秀青年科学基金获得者。
学术成果及影响
致力于T淋巴细胞早期发育、T淋巴细胞抗病毒感染免疫以及肿瘤免疫等方面的研究，以第一或通讯作者（含共）在Nat Immunol、Cell Stem Cell、Nat Commun、PNAS、J Biol Chem、J Immunol等高水平学术期刊发表多篇研究性论文。部分代表性论文简介如下：一、发现DNA序列特异性转录因子Tcf1/Lef1具有组蛋白去乙酰化酶（HDAC）活性，直接修饰组蛋白，调控胸腺CD8+ T淋巴细胞早期发育命运决定。研究工作发表于Nature Immunology（2016），该研究领域知名专家Dan R Littman（美国科学院院士）在Nature Immunology上同期发表专题评论。二、结合Tcf1调控基因网络和生物信息数据库Connectivity Map（CMAP）分析，以及体内外生物学功能筛选，发现小分子化合物PGE1及其FDA批准的PGE1类似物Misoprostol能够阻断Tcf1转录激活的靶基因，治疗白血病（老药物新用途）。该研究工作以封面文章发表于Cell Stem Cell（2017），引起了HematologyTimes、CBS News以及当地媒体The Daily Iowan等积极追踪报道。三、病毒感染及其多肽疫苗免疫情况下，在TFH细胞发育过程中，转录因子Tcf1通过招募磷酸化pS21 Ezh2作为其转录调控Co-activator，激活TFH细胞发育关键基因Program，促进TFH细胞早期发育；同时通过其自身HDAC活性抑制T细胞共抑制通路（T cell co-inhibitory pathways），保护TFH细胞生物学功能发挥。论文分别发表于Nature Communications（2018）、PNAS（2021）。多项研究工作被国际权威学术机构F1000收录，以及被Nat Rev Immunol、Nat Immunol、Immunity和Blood、Leukemia等杂志作为亮点推荐。
代表性论文（近五年，*通讯作者，#共同第一作者）
1. Fengyin Li*, Xin Zhao#, Yali Zhang, Peng Shao, Xiaoke Ma, William J. Paradee, Chengyu Liu, Jianmin Wang, and Hai-Hui Xue*. (2021). TFH cells depend on Tcf1-intrinsic HDAC activity to suppress CTLA4 and guard B-cell help function. PNAS, 118, e2014562118.
2. Fengyin Li, Bing He, Xiaoke Ma, Shuyang Yu, Rupali R. Bhave, Steven R. Lentz, Kai Tan, Monica L. Guzman, Chen Zhao*, Hai-Hui Xue*. (2017). Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1. Cell Stem Cell, 21, 1-15.
3. Shaojun Xing#, Fengyin Li#, Zhouhao Zeng#, Yunjie Zhao, Shuyang Yu, Qiang Shan, Yalan Li, Farrah C Phillips, Peterson K Maina, Hank H Qi, Chengyu Liu, Jun Zhu, R Marshall Pope, Catherine A Musselman, Chen Zeng, Weiqun Peng*, Hai-Hui Xue*. (2016). Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity. Nat Immunol 17, 695-703.
4. Fengyin Li, Zhouhao Zeng, Shaojun Xing, Jodi A. Gullicksrud, Qiang Shan, Jinyong Choi, Vladimir P. Badovinac, Shane Crotty, Weiqun Peng & Hai-Hui Xue*. (2018). Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf. Nat Commun 9, 1-18.
5. Cong Lv#, Fengyin Li#, Xiang Li#, Yuhua Tian#, Yue Zhang, Xiaole Sheng, Yongli Song, Qingyong Meng, Shukai Yuan, Liming Luan, Thomas Andl, XuFeng, Baowei Jiao, Mingang Xu, Maksim V. Plikus, Xing Dai, ChristopherLengner, Wei Cui, Fazheng Ren, Jianwei Shuai, Sarah E. Millar, Zhengquan Yu*. (2017). MiR-31 promotes mammary stem cell expansion and breast tumorigenesisby suppressing Wnt signaling antagonists. Nat Commun 8, 1-18.
6. Shuyang Yu#, Fengyin Li#, Shaojun Xing, Tianyan Zhao, Weiqun Peng, Hai-Hui Xue*. (2016). Hematopoietic and Leukemic Stem Cells Have Distinct Dependence onTcf1 and Lef1 Transcription Factors. J Biol Chem 291, 11148-11160.
7. Yue Zhang#, Fengyin Li#, Yongli Song, Xiaole Sheng, Kai Xiong, Lei Chen, Dequan Liu, Christopher Lengner, Lixiang Xue, Zhengquan Yu*. (2016). Numb and Numbl act to determine mammary myoepithelial cell fate,maintain epithelial identity, and support lactogenesis. FASEB J 30, 3474-3488.
8. Peng Shao#, Fengyin Li#, Jinyong Wang, Xia Chen, Chenyu Liu and Hai-Hui Xue* (2019). Cutting edge: Tcf1 instructs follicular helper cell differentiation by repressing blimp1 in response to acute viral infection. J Immunol, 203: 801-806.
9. Rahul Vijay#, Jenna J Guthmiller#, Alexandria J Sturtz, Fionna A Surette, Kai J Rogers, Ramakrishna R Sompallae, Fengyin Li, Rosemary L Pope, Jo-Anne Chan, Fabian de Labastida Rivera, Dean Andrew, Lachlan Webb, Wendy J Maury, Hai-Hui Xue, Christian R Engwerda, James S McCarthy, Michelle J Boyle, Noah S Butler. (2020). Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria. Nat Immunol 21, 790-801.
10. Xin Zhao, Peng Shao, Kexin Gai, Fengyin Li, Qiang Shan, Hai-Hui Xue. (2020). β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells. eLife 9, e55360.
11. Qiang Shan#, Zhouhao Zeng#, Shaojun Xing, Fengyin Li, Stacey M Hartwig, Jodi A Gullicksrud, Samarchith P Kurup, Natalija Van Braeckel-Budimir, Yao Su, Matthew D Martin, Steven M Varga, Ichiro Taniuchi, John T Harty, Weiqun Peng, Vladimir P Badovinac*, Hai-Hui Xue*. (2017). The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage. Nat Immunol 18, 931-939.
12. Jodi A. Gullicksrud, Fengyin Li, Shaojun Xing, Zhouhao Zeng, Weiqun Peng, Vladimir P. Badovinac, John T. Harty, Hai-Hui Xue*. (2017). Differential Requirements for Tcf1 Long Isoforms in CD8+ and CD4+ T Cell Responses to Acute Viral Infection. J Immunol 3, 911-919.
13. Yan Xiu, Qianze Dong, Qingchang Li, Fengyin Li, Nick Borcherding, Weizhou Zhang, Brendan Boyce, Hai-hui Xue*, Chen Zhao*. (2018). Stabilization of NF-KB-inducing kinase suppresses MLL-AF9–induced acute myeloid leukemia. Cell reports 2, 350-358.
14. Shaojun Xing, Peng Shao, Fengyin Li, Xudong Zhao, WooseokSeo, Justin C. Wheat, Selvi Ramasamy, Jianfeng Wang, Xiang Li, Weiqun Peng, Shuyang Yu, Chengyu Liu, Ichiro Taniuchi, David A. Sweetser, Hai-Hui Xue*. (2018). Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity. J Exp Med 8, 2211-2226.
15. Qi Yang, Fengyin Li, Christelle Harly, Shaojun Xing, Longyun Ye, Xuefeng Xia, Haikun Wang, Xinxin Wang, Shuyang Yu, Xinyuan Zhou, Maggie Cam, Hai-Hui Xue*, Avinash Bhandoola*. (2015). TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow. Nat Immunol 16, 1044-1050.
16. Youn Soo Choi#, Jodi A Gullicksrud#, Shaojun Xing, Zhouhao Zeng, Qiang Shan, Fengyin Li, Paul E Love, Weiqun Peng, Hai-Hui Xue*, Shane Crotty*.(2015). LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6. Nat Immunol 16, 980-990.
团队招聘：
特任副研究员/副教授及博士后，需具有免疫学、生化分子生物学或者细胞生物学背景（有生物信息学分析、病毒感染或者免疫性疾病动物模型实验经验者优先考虑），近期取得博士学位，可独立开展相关科研工作及指导学生；同时热诚欢迎对实验室研究方向感兴趣的本科生前来攻读博士学位。另外，实验室也非常欢迎有兴趣的本科生提早进入实验室开展科研训练。长期招聘，欢迎邮件联系！
联系方式：
E-mail: fyli88@ustc.edu.cn
电话：0551-63600939