教授，中国科学技术大学第一附属医院临床病理中心特聘教授，获评陕西省“三秦人才”。主要从事外科病理诊断以及临床病理研究20余年。擅长淋巴造血系统、软组织和男性泌尿生殖系统病理诊断。
一、学习及工作经历
主要学历：
l1987年-1993年 第四军医大学学员五大队医疗系本科学士
l1995年-1997年第四军医大学基础部病理学教研室读硕士
l1997年-2000年第四军医大学基础部病理学教研室读博士
主要工作经历：
l1993年-1995年 新疆疏勒县解放军第十二医院小儿科医师
l2000年-2005年第四军医大学病理学教研室讲师
l2005年-2007年美国明尼苏达大学Hormel研究所博士后（With Dr. Johnny Lu）
l2007年-今 空军军医大学病理学教研室副教授、教授、副主任、主任
l2019年-今 中国科学技术大学第一附属医院临床病理中心兼职特聘教授
学习经历：
l2007年-2007年 美国佛蒙特大学病理科访问教授（with Dr. Sharon Mount）
l2007年 美国佛罗里达奥兰多佛罗里达医院病理科访问医师（with Dr. M Joe Ma）
l2007年 美国佛罗里达奥兰多地区医院病理科访问医师（with Dr. Shuan Li）
l2012年-2012年 香港伊利沙伯医院病理科进修（with Dr. John K.C Chan）
二、学术成果及影响
致力于病理学教学和科研工作20余年，培养硕士研究生15人，博士研究生7人。在病理诊断工作中发现、命名并报道了新的软组织肿瘤类型Inflammatory Monomorphic Undifferentiated Sarcoma和新的淋巴瘤类型Helper innate lymphoid cell lymphoma；在研究中发现药物诱导白血病凋亡途径中溶酶体蛋白酶Cathepsin D的转位是连接溶酶体与线粒体凋亡途径之间的重要分子；发现乳腺癌的新辅助化疗可以影响肿瘤Her-2免疫组化状态的改变，但不影响其基因扩增的变化；发现了核糖体蛋白激酶RSK4是肾细胞癌独立的预后预测因子，并且是食管鳞状细胞癌肿瘤干细胞相关的恶性生物学行为中的关键激酶。阐明了间变型、窦性和原发胃肠道弥漫大B细胞淋巴瘤的临床和遗传学特点。共发表SCI论文100余篇，其中第一作者和通讯作者40余篇。总引用频次约1830次。获得国家自然科学基金资助6项。主编专著3部，主译专著1部，副主编4部，参编4部。
三、在研项目(仅限于主要负责人)
项目名称、来源、经费指标卡号 | 总经费(万元) | 起止日期 |
：ΔNp63α-RSK4-GSK3β信号轴通过调控肿瘤干细胞促进食管鳞状细胞癌恶性行为 肿瘤生物学国家重点实验室自主课题 CBSKL2020Z07 | 50 | 2021-01至2022-12 |
四、主要研究方向（招生专业）及内容
临床医学
1、临床病理学
1）特殊类型淋巴瘤的基因变异研究
2）结外B细胞淋巴瘤的免疫微环境研究
2、食管鳞状细胞癌恶性行为的分子机制及干预研究
1）食管鳞状细胞肿瘤干细胞形成中关键性激酶的功能研究
2）食管鳞状细胞肿瘤干细胞相关激酶的小分子抑制剂筛选和开发
五、代表性论文（近五年）
1. Li J, Wang Z. The pathology of unusual subtypes of prostate cancer. Chin J Cancer Res. 2016;28(1):130-143. （通讯）
2. Yang Z, Yu L, Wang Z. PCA3 and TMPRSS2-ERG gene fusions as diagnostic biomarkers for prostate cancer. Chin J Cancer Res. 2016;28(1):65-71. （通讯）
3. Shuangping Guo,Yingmei Wang, Joseph Rohr, Chaoliang Fan, Qinglong Li, Xia Li, Zhe Wang. Solid papillary carcinoma of the breast: A special entity needs to be distinguished from conventional invasive carcinoma avoiding over-treatment. The Breast, 2016; 26:67-72 （通讯）
4. Shuangping Guo, Chaoliang Fan, Joseph Rohr, Linni Fan, Yingmei Wang, Mingyang Li, Xia Li, Ying Guo, Qingguo Yan, Lu Wang, Zhe Wang. A clinicopathologic study of paragangliomas of the urinary bladder: can the clinical behavior of the tumor be predicted? Histol Histopathol. 2016; 31(7):785-791（通讯）
5. Jin Zhu, Yuehua Zhang, Weichen Zhang, Wei Zhang, Linni Fan, Lu Wang, Yixiong Liu, Shasha Liu, Ying Guo, Yingmei Wang, Jun Yi, Qingguo Yan, Zhe Wang and Gaosheng Huang. MicroRNA 142-5p contributes to Hashimoto’s thyroiditis by targeting CLDN1. J Transl Med. 2016, 14:166（共同通讯）
6. Shuangping Guo, Xia Li, Joseph Rohr, Yingmei Wang, Shirong Ma, Peng Chen and Zhe Wang. EZH2 overexpression in different immunophenotypes of breast carcinoma and association with clinicopathologic features. Diagnostic Pathology. 2016, 11:41（通讯）
7. Guo S, Bai Q, Rohr J, Wang Y, Liu Y, Zeng K, Yu K, Zhang X, Wang Z. Clinicopathological features of primary diffuse large B-cell lymphoma of the central nervous system – strong EZH2 expression implying diagnostic and therapeutic implication. APMIS. 2016, 124:1056-1062（通讯）
8. Mingyang Li, Yixiong Liu, Yingmei Wang, Gang Chen, Qiongrong Chen, Hualiang Xiao, Fang Liu, Chubo Qi, Zhou Yu, Xia Li, Linni Fan, Ying Guo, Qingguo Yan, Shuangping Guo, Zhe Wang. Anaplastic Variant of Diffuse Large B-cell Lymphoma Displays Intricate Genetic Alterations and Distinct Biological Features. Am J Surg Pathol. 2017, 41(10):1322-1332 （共同通讯）
9. Liu Y, Yu K, Li M, Zeng K, Wei J, Li X, Liu Y, Zhao D, Fan L, Yu Z, Wang Y, Li Z, Zhang W, Bai Q, Yan Q, Guo Y, Wang Z, Guo S. EZH2 overexpression in primary gastrointestinal diffuse large B cell lymphoma and its association with the clinicopathological features. Hum Pathol. 2017,64:213-221（共同通讯）
10. Peipei Xue, Olesya S Malyarenko, Hui Lu, Ruijuan Xiu, Shaoqing Liu, Chen Shao, Jianmin Zhang, Wei Yan, Zhe Wang, Jianyong Zheng, Feng Zhu. BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer. EBioMedicine. 2017,20:50-60 （共同通讯）
11. Li X, Wei J, Liu Y, Li P, Fan L, Wang Y, Li M, Zhao D, Yu Z, Ye J, Guo Y, Yan Q, Guo S, Wang Z. Primary Astrocytic Tumours and Paired Recurrences have Similar Biological Features in IDH1, TP53 and TERTp Mutation and MGMT, ATRX Loss. Sci Rep. 2017, 12;7(1):13038（通讯）
12. Peifeng Li, Jing Ma, Xiumin Zhang, Yong Guo, Yixiong Liu, Xia Li, Danhui Zhao, and Zhe Wang. Cervical small cell carcinoma frequently presented in multiple high risk HPV infection and often associated with other type of epithelial tumors. Diagn Pathol. 2018; 13: 31
13. Chun Cao, Juan Feng, Hongtao Gu, Hailong Tang, Li Xu, Hongjuan Dong, Baoxia Dong, Mimi Shu, Qingxian Bai, Rong Liang, Tao Zhang, Lan Yanga, Zhe Wang, Xiequn Chen, Guangxun Gao. Distribution of lymphoid neoplasms in Northwest China: Analysis of 3244 cases according to WHO classification in a single institution. Annals Diag Pathol. 2018, 34(6):60-65（共同通讯）
14. Liu Y, Ma J, Yu K, Li M, Liu F, Yan Q, Wang Z, Guo S, Expression of programmed cell death 1/programmed cell death ligand 1 in the tumor microenvironments of primary gastrointestinal diffuse large B cell lymphomas. Pathology-Research and Practise, 2018, 214(4): 507-512（共同通讯）
15. Yu, Zhou; Ma, Jing; Li, Xia; Liu, Yixiong; Li, Mingyang; Wang, Lu; Zhao, Ming; He, Huiying; Zhang, Yifen; Rao, Qiu; Zhao, Danhui; Wang, Yingmei; Fan, Linni; Li, Peifeng; Liu, Yang; Liu, Fang; Zhang, Feng; Ye, Jing; Yan, Qingguo; Guo, Shuangping; Wang, Zhe. Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions. Sci Rep; 2018, 8(1): 9972（共同通讯）
16. Shirong Ma, Linni Fan, Yixiong Liu, Yingmei Wang, Kangjie Yu, Lifeng Wang, Na Fang, Fang Liu, Shuangping Guo, Zhe Wang. MET-overexpressing myxofibrosarcoma frequently exhibit polysomy of chromosome 7 but not MET amplification, especially in high-grade cases: clinical and pathological review of 30 myxofibrosarcoma cases. Diag Pathol, 2018,13:56（通讯）
17. Sheng Li, Chao Sun, Yu Gu, Xing Gao, Yuanlin Zhao, Yuan Yuan, Feng Zhang, Peizhen Hu, Weihua Liang, Kaiyu Cao, Jin Zhang, Zhe Wang and Jing Ye. Mutation of IDH1 aggravates the fatty acid induced oxidative stress in HCT116 cells by affecting the mitochondrial respiratory chain. Mol Med Rep. 2019, 19: 2509-2518 . （共同通讯）
18. Fang Liu, Jun-Ping Zheng, Lu Wang, Dan-Hui Zhao, Ming-Yang Li, Ying-Mei Wang, Yang Liu, Jing Ma, Nai-Yan Zeng, Hong-Xiang Liu, Rong Liang, Shuang-Ping Guo, Zhe Wang, Qing-Guo Yan. Activation of the NF-κB Pathway and Heterozygous Deletion of TNFAIP3 (A20) Confer Superior Survival in Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type. Am J Clin Pathol. 2019;152(2):243-252 （共同通讯）
19. Tianqi Xu, Qingge Jia, Yingmei Wang, Yixiong Liu, Donghui Han, Peifeng Li, Jing Ma, Linni Fan, Qingguo Yan, Shuangping Guo, Mingyang Li and Zhe Wang.
Rare cases of primary central nervous system anaplastic variant of diffuse large B-cell lymphoma. Diag Pathol, 2019, 14(1):45.（共同通讯）
20. Peifeng Li,,Mingyang Li, Kaijing Wang, Yixiong Liu, Yingmei Wang, Danhui Zhao, Jia Chai, Jing Ma, Xia Li, Jie Wei, Linni Fan, Feng Zhang, Jing Ye, Qingguo Yan, Shuangping Guo, Zhe Wang. Genetic alterations in cell cycle regulation-associated genes may promote primary progression of gastrointestinal stromal tumors. Lab Invest. 2020; 100(3):426-437. （通讯）
21. Mingyang Li, Xiaoli Su, Yingmei Wang, Linni Fan, Jia Chai, Peifeng Li, Danhui Zhao, Yixiong Liu, Jing Ma, Kaijing Wang, Qingguo Yan, Shuangping Guo, Boquan Jin, Rong Liang and Zhe Wang. Lineage-negative lymphoma with a helper innate lymphoid cell phenotype. Virchows Archiv. 2020; 476(2):285（共同通讯）
22. Jie Wei, Yingmei Wang, Peifeng Li, Linni Fan, Zhe Wang. Small-cell carcinoma-associated ovarian mucinous carcinoma: a case report and literature review. Pathology - Research and Practice, 2019, 215(11): 152619 （通讯）
23. Kangjie Yu, Joseph Rohr, Yang Liu, Mingyang Li, Junpeng Xu, Kaijing Wang, Jia Chai, Danhui Zhao, Yixiong Liu, JingMa, Linni Fan, Zhe Wang, Shuangping Guo. Progress in triple negative breast carcinoma pathophysiology: Potential therapeutic targets. Pathology - Research and Practice, 2020; 216(4):152874 （共同通讯）
24. Jing Ma, Mingyang Li, Jia Chai, Kaijing Wang, Peifeng Li, Yixiong Liu, Danhui Zhao, Junpeng Xu, Kangjie Yu, Qingguo Yan, Shuangping Guo, Zhe Wang, and Linni Fan. Expression of RSK4, CD44 and MMP-9 is upregulated and positively correlated in metastatic ccRCC. Diag Pathol, 2020; 15:28 （共同通讯）
25. Qin Tian, Ping Yuan, Chuntao Quan, Mingyang Li, Juanjuan Xiao, Lu Zhang, Hui Lu, Tengfei Ma, Ling Zou, Fei Wang, Peipei Xue, Xiaofang Ni, Wei Wang, Lin Liu, Zhe Wang, Feng Zhu & Qiuhong Duan. Phosphorylation of BCKDK of BCAA catabolism at Y246 by Src promotes metastasis of colorectal cancer. Oncogene, 2020; 39(20):3980-3996 （共同通讯）
26. Ming-Yang Li, Lin-Ni Fan, Dong-Hui Han, Zhou Yu, Jing Ma, Yi-Xiong Liu, Pei-Feng Li, Dan-Hui Zhao, Jia Chai, Lei Jiang, Shi-Liang Li, Juan-Juan Xiao, Qiu-Hong Duan, Jing Ye, Mei Shi, Yong-Zhan Nie, Kai-Chun Wu, D. Joshua Liao, Yu Shi, Yan Wang, Qing-Guo Yan, Shuang-Ping Guo, Xiu-Wu Bian, Feng Zhu, Jian Zhang and Zhe Wang. Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma. J Clin Invest, 2020; 130(8):4301-4319. （共同通讯）
27. Junpeng Xu, Peifeng Li, Jia Chai, Kangjie Yu, Tianqi Xu, Danhui Zhao, Yixiong Liu, Yingmei Wang, Kaijing Wang, Jing Ma, Linni Fan, Qingguo Yan, Shuangping Guo, Hualiang Xiao, Qilin Ao, Zhaoming Wang, Weiping Liu, Sha Zhao, Weihua Yin, Yuhua Huang, Yaqin Li, Miaoxia He, Rong Liang, Mingyang Li, and Zhe Wang. The clinicopathological and molecular features of sinusoidal large B-cell lymphoma. Mod Pathol, 2021; 34:922-933. （共同通讯）
28. Kangjie Yu, Peifeng Li, Tianqi Xu, Junpeng Xu, Kaijing Wang, Jia Chai, Danhui Zhao, Yixiong Liu, Yingmei Wang, Jing Ma, Linni Fan, Shuangping Guo, Zengshan Li, Mingyang Li, Zhe Wang. Decreased infiltration of CD4+ Th1 cells indicates a good response to ursodeoxycholic acid (UDCA) in primary biliary cholangitis. Pathology - Research and Practice. 2021, 217:153291
29. Peifeng Li, Jia Chai, Zi Chen, Yang Liu, Jie Wei, Yixiong Liu, Danhui Zhao, Jing Ma, Kaijing Wang, Xia Li, Yang.W Shao, Li Gong, Wei Zhang, Shuangping Guo, Yingguo Yan, Mingyang Li, Linni Fan, Zhe Wang. Genomic mutation profile of primary gastrointestinal diffuse large B-cell lymphoma. Frontiers in Oncology. 2021, 11:622648
六、联系方式
E-mail: zhwang@fmmu.edu.cn
电话：0551-62284852 13709220858