主要研究兴趣：
(1).综合利用结构生物学，生物化学和生物物理学的手段研究脂质代谢、调节和转运等生物过程中重要膜蛋白的结构与功能。
(2).综合利用结构生物学和细胞生物学的手段研究细胞膜黏连位点(Membrane contact site)的结构和功能。
1990年出生，中国科技大学生命科学学院特任教授，博士生导师。入选国家海外高层次人才青年项目，安徽省海外创新人才计划。长期从事脂质相关重要膜蛋白的结构和功能研究。在Nature、Science和Cell上发表多篇重要论文。
教育和研究经历：
2009.09-2013.06 华中科技大学生命科学与技术学院 获学士学位
2013.09-2018.01 清华大学生命科学学院 获理学博士学位
2018.04-2021.04 普林斯顿大学分子生物学系 博士后
2021.05至今 中国科学技术大学生命科学与医学部 特任教授、博导
获奖情况：
2019 美国新泽西州NJCCR博士后奖学金
发表论文：
1. Qian, H.*, Wu, X.*, Du, X.*, Yao, X., Zhao, X., Lee, J., … & Yan, N. (2020). Structural basis for low pH-dependent cholesterol egress from lysosomes by NPC1 and NPC2.Cell,182, 98–111. (* Co-first author)
2. Wang, L.*, Qian, H.*, Nian, Y.*, Han, Y.*, Ren, Z., Zhang, H., ... & Zhou, M. (2020). Structure and mechanism of human diacylglycerol O-acyltransferase 1. Nature, 581, 329–332. (* Co-first author).
3. Qian, H.*, #, Zhao, X.*, Yan, R.*, Yao, X., Gao, S., Sun, X., ... & Yan, N. (2020). Structural basis for catalysis and substrate specificity of human ACAT1. Nature, 581, 333–338. (* Co-first author, # Co-corresponding author).
4. Qian, H.*, Cao, P.*, Hu, M., Gao, S., Yan, N., & Gong, X. (2019). Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nature communications, 10(1), 1-9. (* Co-first author).
5. Gong, X., & Qian, H. (2019). Purification and Characterization of Human Niemann–Pick C1 Protein. In Intracellular Lipid Transport (pp. 257-267). Humana Press, New York, NY.
6. an, R.*, Qian, H.*, #, Lukmantara, I., Gao, M., Du, X., Yan, N.#, & Yang, H.# (2018). Human SEIPIN binds anionic phospholipids. Developmental cell, 47(2), 248-256. (* Co-first author, # Co-corresponding author).
7. Gong, X.*, Qian, H.*, Cao, P.*, Zhao, X., Zhou, Q., Lei, J., & Yan, N. (2018). Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science, 361(6402), eaas8935. (* Co-first author).
8. Qian, H.*, Zhao, X., Cao, P., Lei, J., Yan, N.#, & Gong, X.*, # (2017). Structure of the human lipid exporter ABCA1. Cell, 169(7), 1228-1239. (* Co-first author, # Co-corresponding author).
9. Gong, X.*, Qian, H.*, Shao, W.*, Li, J., Wu, J., Liu, J. J., ... & Yan, N. (2016). Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell research, 26(11), 1197-1211. (* Co-first author).
10. Gong, X.*, Qian, H.*, Zhou, X.*, Wu, J.*, Wan, T.*, Cao, P., ... & Shi, Y. (2016). Structural insights into the Niemann-Pick C1 (NPC1)-mediated cholesterol transfer and Ebola infection. Cell, 165(6), 1467-1478. (* Co-first author).
招生招聘：
实验室招聘结构生物学、脂质代谢、细胞生物学等相关背景的博士后和特任（副）研究员，待遇从优。同时热忱欢迎对本实验室研究方向感兴趣的本科生前来攻读博士学位
办公室：中国科学技术大学西校区生命科学学院800A