主要研究兴趣

1. NK细胞和ILC亚群发育分化；

2. NK细胞/ILC1的区域免疫特性；

3. NK细胞/ILC1在重大疾病中的作用及机制。

彭慧，中国科学技术大学特任教授，博士生导师，国家优秀青年基金获得者。本科（2006）和博士（2012）毕业于中国科学技术大学。2012-2014年在中国科学技术大学生命科学学院从事博士后研究工作，2014年至2019年先后被聘为特任副研究员、副教授，2019年11月起任中国科学技术大学生命科学与医学部特任教授。长期从事肝脏免疫学研究，发现了肝脏驻留NK细胞新亚群，围绕其谱系发育、功能、疾病意义取得一系列重要进展，相关成果以（共）第一作者/通讯作者发表在Science、Cell、Immunity、Nature Commun、J Clin Invest、J Exp Med等高水平期刊。获国家自然科学二等奖和中国免疫学会青年学者奖，入选第一届中国科协青年人才托举工程。

代表性论文（*为通讯作者）

Cheng M, Li J, Song J, Song H, Chen Y, Tang H, Wei H, Sun R, Tian Z*, Wang X*, Peng H*. RORα is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis. Cell Rep. 2024;43(2):113786.

Tang F, Li J, Qi L, Liu D, Bo Y, Qin S, Miao Y, Yu K, Hou W, Li J, Peng J, Tian Z, Zhu L*, Peng H*, Wang D*, Zhang Z*. A pan-cancer single-cell panorama of human natural killer cells. Cell. 2023;186(19):4235-4251.

Chen Y, Wang X, Hao X, Li B, Tao W, Zhu S, Qu K, Wei H, Sun R*, Peng H*, Tian Z*. Ly49E separates liver ILC1s into embryo-derived and postnatal subsets with different functions. J Exp Med. 2022;219(5):e20211805.

Song J, Song H, Wei H, Sun R*, Tian Z*, Peng H*. Requirement of RORα for maintenance and antitumor immunity of liver-resident natural killer cells/ILC1s. Hepatology. 2022;75(5):1181-1193.

Bai L, Vienne M, Tang L, Kerdiles Y, Etiennot M, Escalière B, Galluso J, Wei H, Sun R*, Vivier E*, Peng H*, Tian Z*. Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop. Science.2021;371(6536):eaba4177.

Wang X, Tian Z, Peng H*. Tissue-resident memory-like ILCs: innate counterparts of TRM cells. Protein Cell. 2020;11(2):85-96.

Chen Y, Tian Z, Peng H*. Immunological memory: ILC1s come into view. Cell Mol Immunol. 2019;16(12):895-896

Wang B, Zhou J, Chen Y, Wei H, Sun R, Tian Z*, Peng H*. A novel spleen-resident immature NK cell subset and its maturation in a T-bet-dependent manner. J Autoimmun. 2019;105:102307.

Zhou J, Peng H*, Li K, Qu K, Wang B, Wu Y, Ye L, Dong Z, Wei H, Sun R, Tian Z*. Liver-resident NK cells control antiviral activity of hepatic T cells via PD-1/PD-L1 axis. Immunity. 2019;50:403-417.

Bai L, Peng H*, Hao X, Tang L, Sun C, Zheng M, Liu F, Lian Z, Bai L, Wei H, Sun R*, Tian Z*.CD8+ T Cells Promote Maturation of Liver-Resident NK Cells via the CD70-CD27 axis. Hepatology. 2019;70:1804-1815.

Wang X, Peng H*, Cong J, Wang X, Lian Z, Wei H, Sun R*, Tian Z*. Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis. Nat Commun. 2018;9:4854.

Bai L, Peng H*. Generating CD8αα IELs from two sources of thymic precursors. Cell Mol Immunol. 2018;15:640-641. 

Peng H*, Tian Z*. Diversity of tissue-resident NK cells. Semin Immunol. 2017;31:3-10.

Tang L, Peng H*, Zhou J, Chen Y, Wei H, Sun R, Yokoyama WM, Tian Z*. Differential phenotypic and functional properties of liver-resident NK cells and mucosal ILC1s. J Autoimmun. 2016;67:29-35.

Peng H, Tian Z*. Re-examining the origin and function of liver-resident NK cells. Trends Immunol. 2015;36:293-299.

Peng H#, Jiang X#, Chen Y#, Sojka DK, Wei H, Gao X, Sun R, Yokoyama WM, Tian Z*. Liver-resident NK cells confer adaptive immunity in skin-contact inflammation. J Clin Invest. 2013;123:1444-1456.

Peng H, Sun R, Tang L, Wei H, Tian Z*. CD62L is critical for maturation and accumulation of murine hepatic NK cells in response to viral infection. J Immunol. 2013;190(8):4255-62.

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E-mail: huipeng@ustc.edu.cn.