教授，博士生导师，国家优青，安徽省杰青，中国科学院先导专项首席科学家。中国科学技术大学生命科学与医学部，免疫应答与免疫治疗重点实验室PI。2015年博士毕业于中国科学技术大学，主要从事NK细胞与免疫微环境研究，相关成果以（共）通讯发表在Nat Immunol、Clinic Cancer Res、J Hematol Oncol、和Cell Mol Immunol等学术期刊，主持基金委专项、面上项目，省重大项目等，获中国免疫学会青年学者奖。

主要研究兴趣：

1. NK细胞与肿瘤免疫微环境；

2. 发掘肿瘤/自身炎症免疫干预靶点；

3. 利用合成生物学理念，创制免疫治疗新分子；

代表性研究论文：

[1] Xiaohu Zheng#*, Zhuanghao Hou#, Yeben Qian, Yongwei Zhang, Quanwei Cui, Xuben Wang, Yiqing Shen, Zhenbang Liu, Yonggang Zhou, Binqing Fu, Rui Sun, Zhigang Tian*,Guangming Huang* and Haiming Wei*. Tumors evade immune cytotoxicity by altering the surface topology of NK cells. Nature Immunology. 2023 Mar 23.

[2]Dong Wang #, Xiaohui Li #, Defeng Jiao, Ying Cai, Liting Qian, Yiqing Shen, Yichen Lu, Yonggang Zhou, Binqing Fu, Rui Sun, Zhigang Tian, Xiaohu Zheng*, Haiming Wei*. J Hematol Oncol. 2023 Mar 27.

[3] Sanyou Chen#, Wanhe Li#, Xiaohu Zheng#, Pei Yu, Pengfei Wang, Ziting Sun, Yao Xu, Defeng Jiao, Xiangyu Ye, Mingcheng Cai, Mengze Shen, Mengqi Wang, Qi Zhang, Fei Kong, Ya Wang, Jie He, Haiming Wei, Fazhan Shi*, and Jiangfeng Du*, Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond. Proc Natl Acad Sci USA. 2022 Feb 1;119(5):e2118876119.

[4] Xiaohu Zheng*, Yaqi Wu, Jiacheng Bi, Yingying Huang, Ying Cheng, Yangyang Li, Yuwei Wu, Guoshuai Cao, Zhigang Tian*, The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy. 2021 Dec 12. Cell Mol Immunol. 2022 Feb;19(2):192-209

[5] Zhigang Nian, Xiaohu Zheng*, Yingchao Dou, Xianghui Du, Li Zhou, Binqing Fu, Rui Sun, Zhigang Tian, Haiming Wei*, Rapamycin pretreatment rescues the bone marrow AML cell elimination capacity of CAR-T cells, Clinic Cancer Research, 2021 Nov 1;27(21):6026-6038

[6] Jiacheng Bi, Chaoyue Zheng and Xiaohu Zheng*. Increased expression of adenosine A3 receptor in tumor-infiltrating natural killer cells. Cell Mol Immunol. 2021, DOI: 10.1038/s41423-020-00632-1.

[7] Yonggang Zhou#; Binqing Fu#; Xiaohu Zheng#; Dongsheng Wang; Changcheng Zhao; Yingjie qi; Rui Sun; Zhigang Tian; Xiaoling Xu*; Haiming Wei*. Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients. National Science Review. 2020, DOI:10.1093/nsr/nwaa041. 

[8] Xiaohu Zheng, Yeben Qian, Binqing Fu, Defeng Jiao, Yong Jiang, Peng Chen, Yiqing Shen, Huafeng Zhang, Rui Sun, Zhigang Tian* and Haiming Wei *, Mitochondrial fragmentation limits natural killer cell-based tumour immunosurveillance. Nature Immunology, 2019 Dec, 20;1656-1667.

[9] Yong Jiang#, Xiaohu Zheng#, Defeng Jiao, Peng Chen, Yechuan Xu, Haiming Wei*, Yeben Qian*. Peptidase inhibitor 15 as a novel blood diagnostic marker for cholangiocarcinoma. EBioMedicine, 2019 Feb;40:422-431.

[10] Xiaohu Zheng , Fan X, Fu B, Zheng M, Zhang A, Zhong K, Yan J, Sun R, Tian Z*, Wei H*, EpCAM inhibition sensitizes chemoresistant leukemia to immune surveillance. Cancer Research, JAN 15 2017, 77; 482-493.

[11] Xiaohu Zheng, Min Cheng, Binqing Fu, Xiaolei Fan, Qing Wang, Xiaoqing Yu, Rui Sun, Zhigang Tian*, Haiming Wei*.Targeting LunX inhibits non-small-cell lung cancer growth and metastasis. Cancer Research, March 15, 2015 75; 1080-90.

[12] Xiaohu Zheng, Zhigang Tian, Haiming Wei*. Lung specific X protein as a novel therapeutic target for lung cancer. OncoImmunology, 2015 Aug 17;4(12):e1052931.

招生招聘：

1. 实验室招聘具有免疫学、细胞生物学等相关背景的博士后或特任副研究员；

2. 实验室欢迎对肿瘤、免疫学感兴趣的学生前来攻读研究生。

联系方式：ustczxh@ustc.edu.cn