马慧

马慧

2022-08-31来源：生命科学与医学部


博士，副研究员。主要从事精子发生与成熟障碍的调控及分子机理研究，相关研究成果发表在Science Advances，Cell Reports，Journal of Experimental Medicine，Science Bulletin，Genetics in Medicine等高影响力期刊。作为项目负责人获得国家自然科学基金委面上项目、青年科学基金、博士后科学基金（一等）等资助，作为项目骨干参与多项国家重点研发计划项目。


教育与工作经历：

2006-2010，浙江大学生命科学学院，学士

2010-2014，新加坡国立大学医学院，博士

2014-2015，新加坡国立大学医学院，研究助理

2015-2017，中国科学技术大学生命科学学院，博士后

2017-2022，中国科学技术大学生命科学与医学部，特任副研究员

2022年至今，中国科学技术大学生命科学与医学部，副研究员


研究兴趣：

  1. 人类精子发生与成熟障碍的分子机理

  2. 减数分裂的调控机制


代表性论文：(#共同一作，*共同通讯)

  1. Li Y#, Wu Y#, Khan I#, Zhou J, Lu Y, Ye J, Liu J, Xie X, Hu C, Jiang H, Fan S, Zhang H, Zhang Y, Jiang X, Xu B, Ma H*, ShiQ*. M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination. EMBO Reports.2023 Feb 6;24(2):e55778. doi: 10.15252/embr.202255778.（封面文章）

  2. Ma H#, Li T#, Xie X#, Jiang L, Ye J, Gong C, Jiang H, Fan S, Zhang H, Shi B, Zhang B, Jiang X, Li Y, Zhou J, Xu J, Zhang X, Hou X, Yin H*, Zhang Y*, Shi Q*. RAD51AP2 is required for efficient meiotic recombination between X and Y chromosomes. Science Advances. 2022 Jan 14;8(2):eabk1789.

  3. Xu J#, Gao J#, Liu J, Huang X, Zhang H, Ma A, Ye J, Zhang X, Li Y, Yang G, Yin H, Khan R, Li T, Fan S, Jiang X, Zhang Y, Jiang H*, Ma H*, Shi Q*. ZFP541 maintains the repression of pre-pachytene transcriptional programs and promotes male meiosis progression. Cell Reports. 2022 Mar 22;38(12):110540.

  4. Xie X#, Murtaza G#, Li Y, Zhou J, Ye J, Khan R, Jiang L, Khan I, Zubair M, Yin H, Jiang H, Liu W, Shi B, Hou X, Gong C, Fan S, Wang Y, Jiang X, Zhang Y, Zhang H*, Ma H*, Shi Q*. Biallelic HFM1 variants cause non-obstructive azoospermia with meiotic arrest in humans by impairing crossover formation to varying degrees. Human Reproduction. 2022 Jun 30;37(7):1664-1677.

  5. Ma H#, Zhang B#, Khan A#, Zhao D, Ma A, Jianteng Z, Khan I, Khan K, Zhang H, Zhang Y, Xiaohua J, Dil S, Zeb A, Rahim F, Shi Q*. Novel frameshift mutation in STK33 is associated with asthenozoospermia and multiple morphological abnormality of the flagella. Human Molecular Genetics. 2021 Jun 21;ddab165.

  6. Zhang B#, Ma H#*, Khan T#, Li T, Zhang H, Gao J, Zhou J, Ma A, Li Y, Yu C, Bao J, Ali A, Murtaza G, Yin H, Gao Q, Jiang X, Zhang F, Liu C, Khan I, Zubair M, Hussain H. M. J., Khan R, Yousaf A, Yuan L, Lu Y, Tao Q, Hao Q, Fang H, Cheng H, Zhang Y*, Shi Q*. A DNAH17 missense variant causes destabilization of doublets 4-7 in flagella and asthenozoospermia. Journal of Experimental Medicine.2020 Feb 3;217(2):e20182365.

  7. Jiao Y#, Fan S#, Jabeen N#, Zhang H#, Khan R, Murtaza G, Jiang H, Ali A, Li Y, Bao J, Zhang B, Xu J, Xu B, Hussain HMJ, Zaman Q, Khan I, Bukhari I, Iqbal F, Yousaf A, Dil S, Khan M, Ahmad N, Ma H*, Jiang X*, Zhang Y*, Shi Q*. A TOP6BL mutation abolishes meiotic DNA double-strand break formation and causes human infertility. Science Bulletin. 2020 Dec; 65 (24):2120-2129.

  8. Gao Q#, Khan R#, Yu C, Alsheimer M, Jiang X*, Ma H*, Shi Q*. The testis specific LINC component SUN3 is essential for sperm head shaping during mouse spermiogenesis. Journal of Biological Chemistry. 2020 Mar;jbc.RA119.012375.

  9. Yin H#, Ma H#, Hussain S#, Zhang H, Xie X, Jiang L, Jiang X, Iqbal F, Bukhari I, Jiang H, Ali A, Zhong L, Li T, Fan S, Zhang B, Gao J, Li Y, Nazish J, Khan T, Khan M, Zubair M, Hao Q, Fang H, Huang J, Huleihel M, Sha J, Pandita TK, Zhang Y*, Shi Q*. A homozygous FANCM frameshift pathogenic variant causes male infertility. Genetics in Medicine. 2019 Jan;21(1):62-70.

  10. Ma H, Ng HM, Teh X, Li H, Lee YH, Chong YM, Loh YH, Collins JJ, Feng B, Yang H and Wu Q*. Zfp322a regulates mouse ES cell pluripotency and enhances reprogramming efficiency. PLOS Genetics. 2014 Feb;10(2): e1004038.


电子邮箱：clsmh@ustc.edu.cn



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