特任研究员，博士生导师。2015年本科毕业于华中科技大学，2019年博士毕业于清华大学。2019-2022年于西湖大学先后任博士后、助理研究员。2022年11月加入中国科学技术大学生命科学与医学部，组建大分子机器结构与功能实验室。课题组主要利用生物化学和结构生物学等手段，研究参与重要生命过程、与重大疾病相关的大分子机器的工作机理，揭示相关人类疾病的致病机制，促进新药研发。至今，已在Cell、Science、Molecular Cell、Cell Research、Nature Structural & Molecular Biology等期刊发表多篇高水平研究论文。
主要研究方向：
（1）RNA加工、转运和作用的分子机制；
（2）细胞内其它重要生物大分子机器的结构与功能。
代表性论文(first author, #corresponding author)
1. Xiaofeng Zhang, Chuangye Yan#, Jing Hang, Lorenzo Finci, Jianlin Lei and Yigong Shi# (2017). An Atomic Structure of the Human Spliceosome. Cell(Cover Story)
2. Xiechao Zhan, Chuangye Yan, Xiaofeng Zhang, Jianlin Lei and Yigong Shi# (2018). Structure of a Human Catalytic Step I Spliceosome. Science
3. Xiaofeng Zhang, Chuangye Yan, Xiechao Zhan, Lijia Li, Jianlin Lei and Yigong Shi# (2018). Structure of the Human Activated Spliceosome in Three Conformational States. Cell Research(Cover Story)
4. Xiaofeng Zhang, Chuangye Yan, Xiechao Zhan, Wenyu Zhang, Dongliang Liu, Jianlin Lei and Yigong Shi# (2019). Structures of the human spliceosomes before and after release of the ligated exon. Cell Research
5. Jianhua Luo, Qi Yang, Xiaofeng Zhang, Yuanyuan Zhang, Li Wan, Xiechao Zhan, Yao Zhou, Liuqing He, Dnayang Li, Dazhi Jin, Ying Zhen, Jing Huang, Min Dong, Yanyan Li#, and Liang Tao# (2022). TFPI is an intestinal glandular receptor for C. difficile toxin B from the hypervirulent clade 2 lineages. Cell
6. Xiaofeng Zhang#, Fenghua Yang, Xiechao Zhan, Tong Bian, Zhihan Xing, Yichen Lu and Yigong Shi# (2023). Structural Basis of Pre-tRNA Intron Removal by Human tRNA Splicing Endonuclease. Molecular Cell
7. Xiaofeng Zhang#, Xiechao Zhan, Tong Bian, Fenghua Yang, Pan Li, Yichen Lu, Zhihan Xing, Rongyan Fan, Qiangfeng Zhang, Yigong Shi# (2023). Structural Insights into Branch Site Proofreading by Human Spliceosome. Nature Structural & Molecular Biology
8. Xiechao Zhan, Chuangye Yan, Xiaofeng Zhang, Wenyu Zhang, Jianlin Lei and Yigong Shi# (2018). Structures of the human pre-catalytic spliceosome and its precursor spliceosome. Cell Research
9. Lorenzo Finci#, Xiaofeng Zhang, Xiuliang Huang, Qiang Zhou, Jennifer Tsai, Teng Teng, Betty Chan, Sean Irwin, Craig Karr, Andrew Cook, Silvia Buonamici, and Nicholas A. Larsen# (2018). The Cryo-EM Structure of the SF3b Spliceosome Complex Bound to a Splicing Modulator Reveals a Pre-mRNA Substrate Competitive Mechanism of Action.Genes & Development
10.Xiechao Zhan, Yicheng Lu, Xiaofeng Zhang, Chuanye Yan and Yigong Shi# (2022). Mechanism of exon ligation by human spliceosome. Molecular Cell
11.Chengcheng Wang#, Zhouyan Guo, Xiechao Zhan, Fenghua Yang and Xiaofeng Zhang# (2020). Structure of the yeast Swi/Snf complex in a nucleosome-free state. Nature Communications
12.Fenghua Yang, Tong Bian, Xiechao Zhan, Zhe Chen, Zhihan Xing, Nicolas A. Larsen, Xiaofeng Zhang#, and Yigong Shi# (2023). Mechanisms of the RNA Helicases DDX42 and DDX46 in Human U2 snRNP Assembly. Nature Communications
完整列表见：
Google Scholar: https://scholar.google.com/citations?hl=en&user=wn-h3boAAAAJ
招生招聘：
实验室长期招聘生物化学、结构生物学、细胞生物学等相关背景的博士后和副研究员，待遇从优。同时热忱欢迎本科生前来攻读硕士、博士学位。
联系方式：
电话：18515284520
邮箱：xiaofengzhang@ustc.edu.cn