特任教授，博士生导师。国家海外高层次青年人才项目获得者，入选中国科学院率先行动人才计划。2016年博士毕业于中国科学技术大学,2017年至2022年在杜克大学医学中心从事博士后研究工作，2022年8月加入中国科学技术大学生命科学与医学部。主要研究兴趣为肿瘤微环境中代谢紊乱与肿瘤免疫逃逸的关系，通过探索肿瘤发生发展的分子机制，为肿瘤治疗提供潜在药物靶点和新策略。曾获得中科院院长优秀奖，杜克大学Robert J. Fitzgerald Scholar奖。主要工作发表于Nature Cell Biology, Nature Metabolism, Trends in Cell Biology, Nature Communications, Cell Research, Cell Reports等期刊上。
主要研究兴趣与方向：
1. 探索特定代谢物调控肿瘤免疫的作用与机制
2. 肿瘤神经浸润对肿瘤发生发展调控机制的研究
3. 抗肿瘤新药的筛选与探索
代表论文 (按时间顺序，#第一作者,*通讯作者)：
1. L Tan#, T Yin#, H Xiang#, L Wang, P Mudgal, J Chen, Y Ding, G Wang, BW Lim, Y Huang, D Huang, Y Liang, PB. Alexander, KX, E Wang, C Yan, Z Ma, M Tan, QJ Li* & XF Wang*. Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response. Nature Communications (2024). 15:8569.
2. T Yin, G Wang, L Wang, P Mudgal, E Wang, C Pan, P Alexander, H Wu, C Cao, Y Liang, L Tan, D Huang, M Chong, R Chen, W Lim, K Xiang, W Xue, L Wan, H Hu, YH Loh, XF Wang* and, QJ Li*. Breaking NGF-TrkA immunosuppression in melanoma sensitizes immunotherapy for durable memory T cell protection. Nature Immunology (2024), 25: 268–28.
3. Y Liang, C Pan, T Yin, L Wang, X Gao, E Wang, H Quang, D Huang, L Tan, K Xiang, Y Wang, PB Alexander, QJ Li, TP Yao, Z Zhang, and, XF Wang*. Branched-Chain Amino Acid Accumulation Fuels the Senescence-Associated Secretory Phenotype. Advanced Science (2024), 11(2): e2303489.
4. KX Song, JX Wang, De Huang*. Therapy-induced senescent tumor cells in cancer relapse. Journal of the National Cancer Center (2023), 3(4): 273–278.
5. C Pan, R Maeso-Díaz, TR Lewis, K Xiang, L Tan, Y Liang, L Wang, F Yang, T Yin, C Wang, K Du, D Huang, SH Oh, E Wang, BJW Lim, M Chong, PB Alexander, X Yao, VY Arshavsky, QJ Li, AM Diehl, and XF Wang*. Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing. Cell Research (2023), 33(7): 516-532.
6. CC# Lin, J# Yan, MD Kapur #, KL Norris#, CW Hsieh, D Huang, N Vitale, KL Lim, Z Guan, XF Wang, JT Chi, WY Yang, TP Yao*. Parkin coordinates mitochondrial lipid remodeling to execute mitophagy. EMBO Reports (2022) 18: e55191.
7. D Huang#, PB Alexander, QJ Li, and XF Wang*. GABAergic signaling beyond synapses: an emerging target for cancer therapy. Trends in Cell Biology (2022) S0962-8924(22)00195-7.
8. D Huang#, Y Wang, JW Thompson, T Yin, PB Alexander, D Qin, P Mudgal, H Wu, Y Liang, L Tan, C Pan, L Yuan, Y Wan, QJ Li*, and XF Wang*. Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression. Nature Cell Biology (2022). 24: 230–241.
9. S Li#, D Huang#, S Shen, Y Cai, S Xing, G Wu, Z Jiang, Y Hao, M Yuan, N Wang, L Zhu, R Yan, D Yang, L Wang, Z Liu, X Hu, R Zhou, K Qu, A Li, X Duan*, H Zhang*, and P Gao*. Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis. Nature Metabolism (2020).2: 256-269.
10. Y Zhang#, C Li#, C Hu, Q Wu, Y Cai, S Xing, H Lu, L Wang, D Huang, L Sun, T Li, X He, X Zhong, J Wang, P Gao, Z J Smith, W Jia*, and H Zhang*. Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1. EMBO Reports (2019) 20: e48115.
11. L Yuan#, L Zhai, L Qian, D Huang, Y Ding, H Xiang, X Liu, J. W Thompson, J Liu, YH He, XQ Chen, J Hu, QP Kong, M Tan, and XF Wang*. Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death. Cell Research (2018) 28:625-643.
12. Y Ding#, C Gong, D Huang, R Chen, P Sui, KH. Lin, G Liang, L Yuan, H Xiang, J Chen, T Yin, PB. Alexander, QF Wang, EW Song, QJ Li, KC. Wood*, and XF Wang*. Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers. Nature Communications (2018)9: 4274.
13. G Wu#, M Yuan, S Shen, X Ma, J Fang, L Zhu, L Sun, Z Liu, X He, D Huang, T Li, C Li, J Wu, X Hu, Z Li, L Song, K Qu, H Zhang*, and P Gao*. Menin enhances c-Myc-mediated transcription to promote cancer progression. Nature Communications (2017) 8: 15278.
14. X Ma#, L Wang#, D Huang#, Y Li#, D Yang, T Li, F Li, L Sun, H Wei, K He, F Yu, D Zhao, L Hu, S Xing, Z Liu, K Li, J Guo, Z Yang, X Pan, A Li, Y Shi, J Wang*, P Gao*, and H Zhang*. Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway. Nature Communications (2017). 8: 1506.
15. D Huang#, T Li#, L Wang, L Zhang, R Yan, K Li, S Xing, G Wu, L Hu, W Jia, S Lin, C. V. Dang, L Song*, P Gao*, and H Zhang*. Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress. Cell Research (2016). 26:1112-1130.
16. Y Cao#, W Guo#, S Tian, X He, X Wang, X Liu, K Gu, X Ma, D Huang, L Hu, Y Cai, H Zhang, Y Wang*, and P Gao*. miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency. EMBO Journal (2015) 34: 609-623.
17. X Ma#, C Li#, L Sun, D Huang, T Li, X He, G Wu, Z Yang, X Zhong, L Song*, P Gao*, and H Zhang*. Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1. Nature Communications (2014) 5: 5212.
18. D Huang#, T Li, X Li, L Zhang, L Sun, X He, X Zhong, D Jia, L Song, G. L. Semenza, P Gao, and H Zhang*. HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression. Cell Reports (2014). 8: 1930-1942.
19. D Huang#, C Li, and H Zhang*. Hypoxia and cancer cell metabolism. Acta Biochim Biophys Sin. (2014).46: 214-219.
实验室长期招聘具有细胞生物学、分子生物学、免疫学研究背景的博士后与助理研究员，要求具备独立思考与独立开展科研工作的能力、善于沟通、为人真诚，待遇从优。同时诚挚欢迎对本课题组感兴趣的本科生、研究生前来交流和学习。
联系方式：
办公室: 新医学楼（西区）527
E-mail: huangde@ustc.edu.cn