CD8 T细胞不对称分裂与记忆T细胞形成。
T细胞衰老、耗竭等命运决定的表观遗传等分子机制。
肿瘤及感染环境中T细胞与其他细胞间相互作用及其对T细胞命运的影响。
体外干细胞向T细胞分化及相关CAR-T等免疫疗法优化。
特任研究员，博士生导师。2010年毕业于中国科学技术大学，2017年于中国科学技术大学获博士学位，同年进入美国St.Jude 儿童研究医院，师从美国科学院院士Douglas R Green院士进行博士后研究。2023年7月加入中国科学技术大学生命科学与医学部。主要研究围绕T细胞激活后不对称分裂等早期事件对T细胞后续命运功能的影响，取得了一系列学术成果，以第一作者在Nature，Stem Cell Reports，FASEB J等国际知名期刊发表文章多篇，并申请CAR-T治疗相关美国专利两项。
招生招聘：
实验室长期招聘免疫学、分子细胞生物学、表观遗传学等背景的博士后.
热忱欢迎对本课题组方向感兴趣的学生前来攻读硕士、博士学位。
联系方式：guoao@ustc.edu.cn
已发表文章：
Guo A, Huang H, Zhu Z, Chen M, Shi H, Sharma P, Liedmann S, Haydar D, Yang M, Beere H, Krenciute G, Roberts C.W.M, Chi H, and Green D.R. cBAF complex components and MYC cooperate early in CD8+ T cell fate. Nature 2022 https://doi.org/10.1038/s41586-022-04849-0
Zhu Z, Chen X, Guo A, Manzano T, Walsh P, Wills K, Halliburton R, Radko-Juettner S, Carter R, Partridge J, Green D.R., Zhang J, Roberts C.W.M. Mitotic bookmarking by SWI/SNF subunits. Nature 2023 https://doi.org/10.1038/s41586-023-06085-6
Liedmann S, Liu X, Guy C, Crawford JC, Rodrigues D.A., Kuzuoglu-Ozturk D, Guo A, Verbist K.C., Temirov J, Chen M.J., Ruggero D, Zhang H, Thomas P.G., Green D.R. Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate. Molecular Cell. 2022 https://doi.org/10.1016/j.molcel.2022.04.016
Li J*, Guo A*, Wang Q, Li Y, Zhao J, Lu J, Pei G. NF-κB directly regulates β-arrestin-1 expression and forms a negative feedback circuit in TNF-α-induced cell death. FASEB J. 2018 Aug;32(8):4096-4106.
Guo A, Huang S, Yu J, Wang H, Li H, Pei G, Shen L. Single-Cell Dynamic Analysis of Mitosis in Haploid Embryonic Stem Cells Shows the Prolonged Metaphase and Its Association with Self-diploidization. Stem Cell Reports. 2017 May; 8(5):1124-1134.
Li H*, Guo A*, Xie Z, Tu W, Yu J, Wang H, Zhao J, Zhong C, Kang J, Li J, Huang S, Shen L. Stabilization of mouse haploid embryonic stem cells with combined kinase and signal modulation. Scientific Reports. 2017 October 16; 7(1)
Xu H, Yue C, Zhang T, Li Y, Guo A, Liao J, Pei G, Li J, Jing N. Derivation of Haploid Neurons from Mouse Androgenetic Haploid Embryonic Stem Cells. Neuroscience Bulletin. 2017; 33(3):361-364.
Guo A, He D, Xu H, Geng C, Zhao J. Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents. Scientific Reports. 2015; 5(1).
Li J, Wei B, Guo A, Liu C, Huang S, Du F, Fan W, Bao C, Pei G. Deficiency of -arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation. Proceedings of the National Academy of Sciences. 2013 April 15; 110(18):7395-7400.
Chen T, Shen L, Yu J, Wan H,Guo A, Chen J, Long Y, Zhao J, Pei G. Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells. Aging Cell. 2011 October; 10(5):908-911.