2016年于中国科学技术大学化学院获得博士学位,随后进入中国科学技术大学生命科学学院从事博士后研究工作,现任中国科学技术大学生命科学与医学部副教授,微尺度物质科学国家研究中心青年女科学家。2016年获中国科学技术大学博士学位。研究方向主要聚焦于从微观到介观尺度的新型代谢组学分析技术研发及其在神经科学研究中的应用,带领团队独立自主地开发了包括单细胞代谢组学、单溶酶体代谢组学以及基于人工智能的快速超分辨空间代谢组学等一系列世界首个国际领先技术,为神经系统细胞代谢调控研究提供了重要的技术支撑。在Cell, Nature Methods, Nature Machine Intelligence, PNAS 等国际知名期刊杂志发表多篇第一及通讯作者文章,获得国家专利三项,主持国家优秀青年科学基金项目、国自然重大研究计划项目、面上项目及青年项目,参与科技部重点研发计划1项,入选2021年中国科学院青年促进会会员。、
研究方向:
开发从单细胞器、单细胞到组织器官的多尺度代谢组学技术
组学数据新型分析方法研发
依托多尺度代谢组学检测技术,研究发育、肿瘤、衰老及神经退行疾病中代谢组学变化及其分子机制,寻找相关的早期诊断标志物以及治疗方法。
发表文章:
Tiepeng Liao; Zihao Ren; Zhaoliang Chai; Man Yuan; Chenjian Miao; Junjie Li; Qi Chen; Zhilin Li; Ziyi Wang; Lin Yi; Siyuan Ge; Wenwei Qian; Longfeng Shen; Zilei Wang; Wei Xiong(*); Hongying Zhu(*). A super-resolution strategy for mass spectrometry imaging via transfer learning, Nature Machine Intelligence, 2023,5:656-668.
Hongying Zhu(#), Qianqian Li(#), Tiepeng Liao(#), Xiang Yin, Qi Chen, Ziyi Wang, Meifang Dai, Lin Yi, Siyuan Ge, Chenjian Miao, Wenping Zeng, Lili Qu, Zhenyu Ju, Guangming Huang, Chunlei Cang(*) and Wei Xiong(*). Metabolomic Profiling of Single Enlarged Lysosomes. Nature Methods, 2021, 18: 788–798.
Hongying Zhu(#); Ning Wang (#); Lei Yao; Qi Chen; Ran Zhang; Junchao Qian; Yiwen Hou; Weiwei Guo; Sijia Fan; Siling Liu; Qiaoyun Zhao; Feng Du; Xin Zuo; Yujun Guo; Yan Xu; Jiali Li; Tian Xue; Kai Zhong; Xiaoyuan Song; Guangming Huang(*); Wei Xiong(*), Moderate UV Exposure Enhances Learning and Memory by Promoting A Novel Glutamate Biosynthetic Pathway in the Brain, Cell, 2018, 173: 1716~1727
Hongying Zhu(#),Guichang Zou(#), Ning Wang(#), Meihui Zhuang, Wei Xiong(*), Guangming Huang(*),Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry. Proc Natl Acad Sci USA, 2017, 114: 2586-2591.
Xiangkai Kong (#), Hongying Zhu(#), ChangLe Chen(*), Guangming Huang (*), Qianwang Chen(*). Insights into the reduction of 4-nitrophenol to 4-aminophenol on catalysts. Chem. Physi. Lett., 2017, 684: 148–152
Hongying Zhu, Guangming Huang(*), Humidity independent mass spectrometry for gas phase chemical analysis via ambient proton transfer reaction. Anal. Chim. Acta.,2015, 867: 67~73
Hongying Zhu, Gongyu Li, Guangming Huang(*). Screening of complicated matrixes with paper assisted ultrasonic spray ionization mass spectrometry. J. Am. Soc. Mass Spectrom.,2014, 25(6):935~942
Hongying Zhu, Yonggang Feng, Jun Yang(*), Wenjie Pan, Zhanghai Li, Yonggao Tu, Xiaolan Zhu, Guangming Huang. Separation and characterization of sucrose esters from Oriental tobacco leaves using accelerated solvent extraction followed by SPE coupled to HPLC with ion-trap MS detection. J. Sep. Sci., 2013, 36(15):2486~2495
联系方式:
邮箱:zhuhy62@ustc.edu.cn;
通讯地址:安徽省合肥市蜀山区中国科学技术大学西校区科技楼917
实验室主页:http://x-lab.ustc.edu.cn/